Results 51 to 60 of about 3,261,902 (400)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Transformational Bureaucratic Leadership Model to Support National Defense Policy in Indonesia
JSP: Jurnal Ilmu Sosial dan Ilmu Politik, 2023 Globalization has produced a complex strategic environment, posting a dynamic threat to national security. In this case, a strategic form of leadership becomes important in running a country, especially in the context of national defense.
Sjafrie Sjamsoeddin +3 more
doaj +1 more source
Genome biology, 2006 The Nobel process for science are often somewhat controversial for who they omit. A posthumous Nobel honor could help recognize some neglected heroes.
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Hydrogel-based delivery of MSCs and derivatives for improved diabetic retinopathy therapy
Stem Cell Research & TherapyDiabetic retinopathy (DR), the most prevalent ocular complication of diabetes, progresses from non-proliferative (NPDR) to sight-threatening proliferative (PDR) stages.
Ludan Sun +7 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
2021 IEEE/CVF International Conference on Computer Vision (ICCV), 2021 Self-attention networks have revolutionized natural language processing and are making impressive strides in image analysis tasks such as image classification and object detection. Inspired by this success, we investigate the application of self-attention networks to 3D point cloud processing.
Zhao, H +4 more
openaire +3 more sources
Project uncertainty, project risk and project leadership : a policy capturing study of New Zealand project managers : a thesis presented in partial fulfillment of the requirements for the degree of Master of Arts in Psychology at Massey University, Wellington, New Zealand [PDF]
, 2016 Cooperation between project practice and project research could help reduce failure rates for projects in New Zealand and globally. The current research used a “policy capturing” method - systematically varying sources of project uncertainty (policy ...
Mercer, Brendon
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Politics in a New Key: Breaking the Cycle of U.S. Politics with a Generational/Developmental Approach [PDF]
Integral Review, 2010 Some common, mental models shape how people in the US perceive political changes over time. The one-dimensional pendulum swing model and the two-dimensional cyclical model are prevalent. When generational differences are mapped onto such political change
Ken White
doaj