Results 61 to 70 of about 330,943 (292)

The Role of Electronic Services in Transformational Government: A Unified Services Theory Perspective and Implications for Trust [PDF]

, 2011
A major difficulty in deriving practical managerial insights from the transformational government perspective is that in the existing literature ‘transformation’ is usually expressed in terms of desirable qualities rather than concrete transformation of ...
Batista, Luciano
core  

Affirmational and Transformational Values and Practices in the Tolkien Fanfiction Community [PDF]

, 2020
Fanfiction based on the legendarium of J.R.R. Tolkien has existed for at least six decades and has been, within the past two, one of the most consistently active online fanfiction communities. Despite this, the fandom has been relatively unstudied by fan
Walls-Thumma, Dawn M.
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Life cycle assessment of pharmaceutical tablet manufacturing: A comparative analysis and systems model integration framework

International Journal of Pharmaceutics: X
Pharmaceutical drug products in the form of tablets are produced via a series of manufacturing steps, transforming powder blends to compacted granules with carefully selected properties such as tensile strength and dissolution time.
Flora Bouchier, Astrid Boje, Gavin Reynolds   +2 more
doaj   +1 more source

Transforming vaccinology

Cell
The COVID-19 pandemic placed the field of vaccinology squarely at the center of global consciousness, emphasizing the vital role of vaccines as transformative public health tools. The impact of vaccines was recently acknowledged by the award of the 2023 Nobel Prize in Physiology or Medicine to Katalin Kariko and Drew Weissman for their seminal ...
Rino Rappuoli, Galit Alter, Bali Pulendran   +2 more
openaire   +3 more sources

Appell Transformation and Canonical Transforms [PDF]

Symmetry, Integrability and Geometry: Methods and Applications, 2011
The interpretation of the optical Appell transformation, as previously elaborated in relation to the free-space paraxial propagation under both a rectangular and a circular cylindrical symmetry, is reviewed. Then, the caloric Appell transformation, well known in the theory of heat equation, is shown to be amenable for a similar interpretation involving
openaire   +5 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Investigating the Impact of Leadership Styles on Finance and Accounting Specialists’ Performance

Buhalterinės Apskaitos Teorija ir Praktika
This study examined the impact of leadership styles (transformational, transactional, and democratic) on finance and accounting specialists’ productivity and commitment in selected deposit money banks in Akure, Ondo State, Nigeria.
Isaac Olufemi Adesuyi, Isaac Olakunle Oludoyi, Funke Bamise, Abiola Joshua Ajani   +3 more
doaj   +1 more source

Metamorphosis: Transforming Non-designers into Designers [PDF]

, 2009
In this paper we make the case that there is today a growing number of educational settings experiencing challenges when it comes to transforming non-designers into designers, and in particular, interaction designers.
Siegel, Martin A, Stolterman, Erik
core  

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source