Results 41 to 50 of about 1,989,040 (349)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Opinions of Health Employees About the Health Transformation Project

open access: yesSağlık ve Hemşirelik Yönetimi Dergisi, 2014
OBJECTIVE: This study was conducted to determine the opinions of health employees who work in public hospitals in İstanbul, about the health transformation project. METHODS: This study was cross sectional and descriptive.
Arzu Kader Harmancı Seren
doaj   +1 more source

Isospectrals of non-uniform Rayleigh beams with respect to their uniform counterparts [PDF]

open access: yesRoyal Society Open Science, 2018
In this paper, we look for non-uniform Rayleigh beams isospectral to a given uniform Rayleigh beam. Isospectral systems are those that have the same spectral properties, i.e. the same free vibration natural frequencies for a given boundary condition.
Srivatsa Bhat K, Ranjan Ganguli
doaj   +1 more source

Lorenz integrable system moves \`a la Poinsot

open access: yes, 2003
A transformation is derived which takes Lorenz integrable system into the well-known Euler equations of a free-torque rigid body with a fixed point, i.e. the famous motion \`a la Poinsot.
Dalmedico   +15 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Selected Problems of Determining Critical Loads in Sructures with Stable Post-Critical Behaviour. [PDF]

open access: yes, 2016
This paper presents selected cases of inapplicability of theory based methods of determining critical loads in thin – walled, composite tubes. 8th layered composite tubes with square cross-section were being subjected to static compression and in order ...
Czapski, Paweł, Kubiak, Tomasz
core  

Diffractive Photoproduction of Eta_c

open access: yes, 2003
Diffractive photoproduction of $\eta_c$ is an important process to study the effect of Odderon, whose existence is still not confirmed in experiment.
Adloff   +49 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

HEAT CONDUCTED THROUGH FINS OF VARYING CROSS-SECTIONS VIA ROHIT TRANSFORM

open access: yes, 2023
The conduction of heat takes place through the fins or spines from particle to particle due to temperature gradient in the direction of decreasing temperature. Heat is not lost equally by each element of the fin but is lost mostly near the base of the fin. Thus there would be wastage of the material if a uniform fin is used.
Pandita, Neeraj, Gupta, Rohit
openaire   +1 more source

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