Results 51 to 60 of about 216,291 (268)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Zgodovina geodetskih meritev na Triglavskem ledeniku : The History of Geodetic Surveys on Triglav Glacier [PDF]

Geodetski Vestnik, 2008
The regular measurements of Triglav glacier on yearly basis began in 1946. At first the measurements involved hand measurements of glacier retreat from permanently marked points on rocks around theglacier.
Mihaela Triglav Čekada, Matej Gabrovec
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Reinventing artisanal knowledge and practice: a critical review of innovation in a craft-based industry

Prometheus, 2013
This paper presents a critical review of the ways in which the specialised knowledge and working practices of craft-based industries have been transformed in the context of broader processes of industrialisation and global competition.
Richard K. Blundel, David J. Smith   +1 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

3D Interpolation Method for CT Images of the Lung [PDF]

Journal of Systemics, Cybernetics and Informatics, 2003
A 3-D image can be reconstructed from numerous CT images of the lung. The procedure reconstructs a solid from multiple cross section images, which are collected during pulsation of the heart.
Noriaki Asada, Mayumi Ogura
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Cutoff brane vs the Karch-Randall brane: the fluctuating case

Journal of High Energy Physics
Recently, certain holographic Weyl transformed CFT2 is proposed to capture the main features of the AdS3/BCFT2 correspondence [1, 2]. In this paper, by adapting the Weyl transformation, we simulate a generalized AdS/BCFT set-up where the fluctuation of ...
Jiong Lin, Yizhou Lu, Qiang Wen
doaj   +1 more source

On the steady flow of non-newtonian fluid through multi-stenosed elliptical artery: A theoretical model

Ain Shams Engineering Journal
The study of blood flow through stenotic arteries is more important as the existence and progression of stenosis may lead to severe damage. The current study aims to analyze and understand the non-Newtonian nature of blood flow through the multi-stenosed
Muhammad Hasnain Shahzad, Sohail Nadeem, Aziz Ullah Awan, Seham Ayesh Allahyani, N. Ameer Ahammad, Sayed M. Eldin   +5 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source