Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Fabrication of graphene-based resistive sensor for eschericia coli bacteria sensing [PDF]
, 2018 The presence of fecal coliform bacteria like Escherichia coli (E. coli) in aquatic environments indicates that the water has been contaminated with the fecal material of human or animals. The risk of health threatening to humans become high when E.
Wibowo, Kusnanto Mukti
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Investigation of Asymetric Modes of Three-phase Three - legs Phase-shifting Transformer with “Inverse Double Zigzag” Scheme of Windings Connections and Commutation in Neutral Point [PDF]
Problems of the Regional Energetics, 2015 The model for power three-phase three limbs phase-shifting transformer with “inverse double zig-zag connection” was investigated. Calculations and research of steady state asymmetric modes of transformer with such windings connection were fulfilled ...
Bosneaga V.A, Suslov V.M.
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Binary magnetic memory device Patent [PDF]
, 1965 Nondestructive interrogating and state changing circuit for binary magnetic storage ...
Schaefer, D. H.
core +1 more source
Development of a smart transformer to control the power exchange of a microgrid [PDF]
, 2013 A smart transformer enables to control the power exchange between a microgrid and the utility network by controlling the voltage at the microgrid side within certain limits.
De Kooning, Jeroen +3 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Investigation of Novel Solid Dielectric Material for Transformer Windings. [PDF]
Polymers (Basel), 2023 Ersoy A, Atalar F, Aydoğan A.
europepmc +1 more source
Partial Discharge in Electronic Equipments [PDF]
, 2009 Tato disertační práce se věnuje studiu částečných výbojů (PD) způsobených poklesem spolehlivosti a životnosti elektronických zařízení a systémů. Diagnostika PD je dnes známá metoda pro vysoké napětí u vysoko-výkonných zařízení.
Mammadov, Anar
core