Results 61 to 70 of about 13,909 (173)

Plasma levels of transforming growth factor-beta1 reflect left ventricular remodeling in aortic stenosis.

PLoS ONE, 2009
BackgroundTGF-beta1 is involved in cardiac remodeling through an auto/paracrine mechanism. The contribution of TGF-beta1 from plasmatic source to pressure overload myocardial remodeling has not been analyzed.
Ana V Villar, Manuel Cobo, Miguel Llano, Cecilia Montalvo, Francisco González-Vílchez, Rafael Martín-Durán, María A Hurlé, J Francisco Nistal   +7 more
doaj   +1 more source

Thermo‐Chemically Modified Silk Scaffolds Reveal Niche‐Driven Regulation of Hematopoiesis and Fibrosis

Small, Volume 22, Issue 18, 25 March 2026.
We introduce a versatile 3D platform that recreates key physical and biological features of the human bone marrow. By integrating tunable silk biomaterials, stromal cells, and human hematopoietic progenitors, the model captures both healthy and diseased microenvironments, analysis of blood formation, and its disruption in pathological conditions ...
Christian A. Di Buduo, Carolina P. Miguel, Giulia Della Rosa, Vittorio Abbonante, Santo Diprima, Delfina Tosi, Marta Filibian, Daniele Cattaneo, Jugal Kishore Sahoo, Nicola Tirelli, Alessandra Iurlo, Umberto Gianelli, David L. Kaplan, Alessandra Balduini   +13 more
wiley   +1 more source

CD44‐Targeted Antioxidant Nanosheets Attenuate Pulmonary Fibrosis by Inhibiting the ROS‐STAT1‐CXCL10 Axis

Small Structures, Volume 7, Issue 3, March 2026.
Here, we report a CD44‐targeted antioxidant nanoplatform based on chondroitin sulfate‐functionalized MoS2 nanosheets (CLM NSs). In a murine pulmonary fibrosis model, CLM NSs achieve lesion‐specific accumulation, scavenge reactive oxygen/nitrogen species, and inhibit fibroblast activation and epithelial‐mesenchymal transition by blocking the ROS‐STAT1 ...
Wencheng Gong, Yu Huang, Ting Wang, Hanchao Zhou, Yue Zhang, Chen Zhang, Ke Wang, Lijuan Liu   +7 more
wiley   +1 more source

Prognostic value of fetal growth and prenatal functional echocardiography in tetralogy of FALLOT

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 3, Page 479-491, March 2026.
First demonstration that fetal growth and pulmonary peak velocity at third trimester are independent predictors of postnatal outcome in Tetralogy of Fallot. This may enhance the accuracy of prenatal counseling and facilitate more individualized planning for delivery and neonatal care. Abstract Introduction Tetralogy of Fallot (ToF) shows variability in
Laura Nogué, Mar Bennasar, Laura Guirado, Felix Zölner, Justus Reitz, Roland Axt‐Fliedner, María C. Escobar‐Díaz, Josep Maria Martínez, Eduard Gratacós, Fàtima Crispi, Olga Gómez, for the BCNatal and Gießen and Marburg University investigators, Míriam Pérez‐Cruz, Narcís Masoller, Franziska Holland, Mireia Caballero, Marta Guilleumes, Sergi Cesar   +17 more
wiley   +1 more source

Ursolic acid inhibits epithelial-mesenchymal transition in vitro and in vivo

Pharmaceutical Biology, 2019
Context: Ursolic acid (UA; 3β-hydroxy-urs-12-en-28-oic acid), one of the pentacyclic triterpenoids found in various plants and herbs, possesses some beneficial effects under pathological conditions, including combating hepatic fibrosis.
Chang-Geng Xu, Xia-Lian Zhu, Wei Wang, Xiang-Jun Zhou   +3 more
doaj   +1 more source

Involvement of transforming growth factor beta-1 (TGFβ1) cytokine and FOXP3 transcription factor genetic polymorphisms in hematological malignancies

Brazilian Archives of Biology and Technology, 2015
Hematological malignancies (HM) are a group of neoplastic diseases that arise from hematologic cell lineages. Transforming growth factor beta 1 (TGFβ1) is shown to negatively regulate normal and malignant hematopoiesis and, in immunological context, to ...
Glauco Akelinghton Freire Vitiello, Roberta Losi Guembarovski, Carlos Eduardo Coral de Oliveira, Marla Karine Amarante, Aparecida de Lourdes Perim, Maria Angelica Ehara Watanabe   +5 more
doaj   +1 more source

Growth regulation of simian and human AIDS-related non-Hodgkin's lymphoma cell lines by TGF-β1 and IL-6

BMC Cancer, 2007
Background AIDS-related non-Hodgkin's lymphoma (AIDS-NHL) is the second most frequent cancer associated with AIDS, and is a frequent cause of death in HIV-infected individuals. Experimental analysis of AIDS-NHL has been facilitated by the availability of
Levy Laura S, Puetter Adriane, Ruff Kristin R   +2 more
doaj   +1 more source

Visfatin Reduces Gap Junction Mediated Cell-to-Cell Communication in Proximal Tubule-Derived Epithelial Cells

Cellular Physiology and Biochemistry, 2013
Background/Aims: In the current study we examined if the adipocytokine, visfatin, alters connexin-mediated intercellular communication in proximal tubule-derived epithelial cells.
Claire E. Hills, Michael I. Kerr, Mark J. Wall, Paul E. Squires   +3 more
doaj   +1 more source

The Different Concentrations of Transforming Growth Factor-Beta1 (TGF-Beta1), Matrix Metalloproteinase-9 (MMP-9) and Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) in Normoalbuminuria Normotension, Normoalbuminuria Hypertension

Indonesian Biomedical Journal, 2009
BACKGROUND: Vascular remodelling was an adaptive process of the vascular wall that occurred in response to long-term changes in hemodynamic conditions that contribute to the changes of the vascular structure and the pathophysiology of vascular disease ...
Johnson Wijaya, Marsetio Donosepoetro, Syakib Bakri   +2 more
doaj   +1 more source

Moxibustion enables protective effects on rheumatoid arthritis-induced myocardial injury transforming growth factor beta1 signaling and metabolic reprogramming. [PDF]

J Tradit Chin Med, 2023
Miao W, Yan Z, Hui Z, Hongfang Z.
europepmc   +1 more source