Results 121 to 130 of about 335,996 (268)

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Transforming growth factor β induced as a novel secreted immune checkpoint counterinhibiting human tumor-associated T cells. [PDF]

J Immunother Cancer
Rosado MM, Timperi E, Melaiu O, Vitale S, Bachy S, Grimaldi A, Corrado M, Mancini V, Leonti G, Conti F, Cammarata I, Celardo I, Kucykowicz S, Aidoo-Micah G, Gragera P, Accapezzato D, Del Ben M, D'Oria V, De Stefanis C, Forcina L, Frattaroli F, Picchetto A, Chiaretti M, D'Ambrosio G, Giannini G, Belardinilli F, Scarinci A, Grazi GL, Musarò A, Maini MK, Fiori ME, Fruci D, Hennino A, Barnaba V.   +33 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Latent-Transforming growth factor - β Binding protein 1 (LTBP1) in corneal stroma. [PDF]

Matrix Biol Plus
Poonen-Honig I, Acosta AC, Sun M, Emerick V, Avila MY, Margo CE, Espana EM.   +6 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Transforming Growth Factor-β Signaling in Alcohol-Associated Liver Disease: A Multicellular Perspective. [PDF]

Am J Pathol
Zou H, Wang S, Huang C, Dooley S, Meindl-Beinker NM.   +4 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pirfenidone Mitigates Transforming Growth Factor-β-induced Inflammation after Viral Infection. [PDF]

Am J Respir Cell Mol Biol
Thomas BJ, Kan-O K, Gantier MP, Simpson I, Chitty JG, Lam M, Dousha L, Gottschalk TA, Lawlor KE, Tate MD, Ruwanpura S, Seow HJ, Loveland KL, Deshpande S, Li X, Hamza K, King PT, Elias JA, Vlahos R, Bourke JE, Bardin PG.   +20 more
europepmc   +1 more source

Transforming Growth Factor [PDF]

, 2020
openaire   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source