Results 151 to 160 of about 1,959,600 (358)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Investigating the role of transforming growth factor-beta/transforming growth factor-beta receptor in the development of hepatocellular carcinoma through the Salvador-Warts-Hippo pathway. [PDF]

Int J Mol Cell Med
Moradi S, Abdul Kareem R, Sameer HN, Dadkhoda S, Yaseen A, Athab ZH, Adil M, Jamali Hondori M, Gandomkar H.   +8 more
europepmc   +1 more source

Changes of Circulating Transforming Growth Factor-²1 Level During Radiation Therapy Are Correlated with the Prognosis of Locally Advanced Non-small Cell Lung Cancer [PDF]

, 2010
Lujun Zhao, Wei Ji, Li Zhang, Guangfei Ou, Qinfu Feng, Zongmei Zhou, Mingfang Lei, Weizhi Yang, Lühua Wang   +8 more
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Latent-Transforming growth factor - β Binding protein 1 (LTBP1) in corneal stroma. [PDF]

Matrix Biol Plus
Poonen-Honig I, Acosta AC, Sun M, Emerick V, Avila MY, Margo CE, Espana EM.   +6 more
europepmc   +1 more source

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

Proceedings of the National Academy of Sciences of the United States of America, 1993
A. Kulkarni, C. Huh, D. Becker, A. Geiser, Marion Lyght, K. Flanders, A. Roberts, M. Sporn, Jerrold M. Ward, S. Karlsson   +9 more
semanticscholar   +1 more source

Microglial Transforming Growth Factor-β Signaling in Alzheimer’s Disease [PDF]

Natascha Vidovic, Björn Spittau
openalex   +1 more source

Effects of PI3‐k/Akt short hairpin RNA on proliferation, fibronectin production and synthesis of thrombospondin‐1 and transforming growth factor‐β₁ in glomerular mesangial cells induced by sublytic C5b‐9 complexes [PDF]

, 2009
Liyuan Gao, Y. Zhang, Wen Qiu, Weiguo Xu, Xin‐Hua Feng, Juanjuan Ren, Xiaoming Jiang, H. Wang, Dan Zhao, Y. Wang   +9 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source