Results 151 to 160 of about 1,084,742 (347)

TGF beta type II receptor signaling controls Schwann cell death and proliferation in developing nerves [PDF]

, 2006
During development, Schwann cell numbers are precisely adjusted to match the number of axons. It is essentially unknown which growth factors or receptors carry out this important control in vivo.
D'Antonio, M, Droggiti, A, Feltri, ML, Jessen, KR, Mirsky, R, Roes, J, Wrabetz, L   +6 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The role of integrins in pulmonary fibrosis

European Respiratory Review, 2008
Integrins are a large family of transmembrane glycoprotein receptors initially identified as mediators of cell adhesion and tissue integrity. However, it is now known that the primary function of integrins in mammals is to act as signalling proteins ...
D. Sheppard
doaj  

Curcumin inhibits transforming growth factor β induced differentiation of mouselung fibroblasts to myofibroblasts

Frontiers in Pharmacology, 2016
Transforming growth factor β (TGFβ) induced differentiation of lung fibroblasts to myofibroblasts is a key event in the pathogenesis of pulmonary fibrosis.
Daishun Liu, Ling Gong, Honglan Zhu, Shenglan Pu, Yang Wu, Wei Zhang, Guichuan Huang   +6 more
doaj   +1 more source

Transforming growth factor-β signaling in thymic epithelial cells : its role in development, steady-state and immune reconstitution

, 2010
The thymus constitutes the primary lymphoid organ responsible for the generation of naive T cells. Its stromal compartment is composed of a scaffold of different subsets of epithelial cells that provide soluble and membrane-bound molecules essential for thymocyte maturation and selection.
openaire   +3 more sources

The Regulatory Effects of Transforming Growth Factor-β on Nerve Regeneration

Cell Transplantation, 2017
Transforming growth factor-β (TGF-β) belongs to a group of pleiotropic cytokines that are involved in a variety of biological processes, such as inflammation and immune reactions, cellular phenotype transition, extracellular matrix (ECM) deposition, and ...
Shiying Li, X. Gu, Sheng Yi
semanticscholar   +1 more source

Stromal control of oncogenic traits expressed in response to the overexpression of GLI2, a pleiotropic oncogene. [PDF]

, 2009
Hedgehog signaling is often activated in tumors, yet it remains unclear how GLI2, a transcription factor activated by this pathway, acts as an oncogene. We show that GLI2 is a pleiotropic oncogene.
Albertson, DG, Connelly, ST, Huey, B, Jordan, RCK, Roy, R, Schmidt, BL, Snijders, AM   +6 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Transforming growth factor beta (TGF-β) in adolescent chronic fatigue syndrome

Journal of Translational Medicine, 2017
Background Chronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescent. The disease mechanisms are unknown. Previous studies have suggested elevated plasma levels of several cytokines, but a recent meta-analysis of 38 articles ...
Vegard Bruun Wyller, Chinh Bkrong Nguyen, Judith Anita Ludviksen, Tom Eirik Mollnes   +3 more
doaj   +1 more source

Additional file 1: of Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis

, 2019
Online Supplementary Methods Section. (DOCX 20 kb)
Miao, Yutian, Shen, Qiang, Zhang, Siheng, Huang, Hehai, Meng, Xiaojing, Zheng, Xianchong, Yao, Zhuocheng, He, Zhanxin, Lu, Sitong, Cai, Chunqing, Zou, Fei   +10 more
openaire   +1 more source