Results 91 to 100 of about 523,619 (399)

Cytokine-related genes identified from the RIKEN full-length mouse cDNA data set [PDF]

, 2003
To identify novel cytokine-related genes, we searched the set of 60,770 annotated RIKEN mouse cDNA clones (FANTOM2 clones), using keywords such as cytokine itself or cytokine names (such as interferon, interleukin, epidermal growth factor, fibroblast ...
Brusic, V., GSL Members., Petrovsky, N., Pillai, R. S., Riken Ger Group, Schonbach, C., Silva, D. G.   +6 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Role of transforming growth factor-beta in the development of the mouse embryo

Journal of Cell Biology, 1987
Using immunohistochemical methods, we have investigated the role of transforming growth factor-beta (TGF-beta) in the development of the mouse embryo. For detection of TGF-beta in 11-18-d-old embryos, we have used a polyclonal antibody specific for TGF ...
URSULA I. Heine, Eliana E Munoz, Kathy Flanders, L. Ellingsworth, H.-Y Peter Lain, N. L. Thompson, A. B. Roberts, M. Sporn   +7 more
semanticscholar   +1 more source

Smad signalling in the ovary [PDF]

, 2006
has now been a decade since the first discovery of the intracellular Smad proteins, the downstream signalling molecules of one of the most important growth factor families in the animal kingdom, the transforming growth factor beta (TGF-beta) superfamily.
Jeffrey, Luke A., Kaivo-oja, Noora, Mottershead, David G., Ritvos, Olli   +3 more
core   +3 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Diverse Biological Processes Contribute to Transforming Growth Factor β-Mediated Cancer Drug Resistance

Cells
Therapy resistance is a major obstacle to cancer treatment, and transforming growth factor-beta (TGF-β) signaling has emerged as a major instigator across many cancer types and therapeutic regimens.
James P. Heiserman, Rosemary J. Akhurst
doaj   +1 more source

Transforming growth factor beta family expression at the bovine feto-maternal interface

Reproductive Biology and Endocrinology, 2010
Background Endometrial remodelling is necessary for implantation in all mammalian species. The TGF beta super-family plays a crucial role in this event in humans and mice.
Herath Chandana B, Kizaki Keiichiro, Sugawara Kumiko, Hasegawa Yoshihisa, Hashizume Kazuyoshi   +4 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Interleukin-6, vascular endothelial growth factor and transforming growth factor beta 1 in canine steroid responsive meningitis-arteritis

BMC Veterinary Research, 2013
Background Steroid Responsive Meningitis-Arteritis (SRMA) is a common cause of inflammation of the canine central nervous system (CNS). To investigate if transforming growth factor beta 1 (TGF-β1), interleukin-6 (IL-6) and vascular endothelial growth ...
Maiolini Arianna, Otten Meike, Hewicker-Trautwein Marion, Carlson Regina, Tipold Andrea   +4 more
doaj   +1 more source

Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur

Journal of Cell Biology, 1990
We have investigated the ability of exogenous transforming growth factor-beta (TGF-beta) to induce osteogenesis and chondrogenesis, critical events in both bone formation and fracture healing.
Michael E. Joyce, A. Roberts, M. Sporn, M. Bolander   +3 more
semanticscholar   +1 more source