Expression of transforming growth factor‐beta isoforms and their receptors in chronic tendinosis [PDF]
, 2001 Chronic tendon lesions are degenerative conditions and may represent a failure to repair or remodel the extracellular matrix after repeated micro-injury.
Steven Fenwick +5 more
openalex +3 more sources
TGF beta 1 attenuates expression of prolactin and IGFBP-1 in decidualized endometrial stromal cells by both SMAD-dependent and SMAD-independent pathways [PDF]
, 2010 Background: Decidualization (differentiation) of the endometrial stromal cells during the secretory phase of the menstrual cycle is essential for successful implantation.
Brosens, Jan J. +6 more
core +12 more sources
Role of growth factors in the pathogenesis of tissue fibrosis in systemic sclerosis. [PDF]
, 2010 The most severe clinical and pathologic manifestations of systemic sclerosis (SSc) are the result of a fibrotic process characterized by the excessive and often progressive deposition of collagen and other connective tissue macromolecules in skin and ...
Castro, Susan V. +2 more
core +2 more sources
Transforming growth factor beta (TGF-β) in milk: a review
Revista do Instituto de Latícinios Cândido Tostes, 2016 Bovine milk and colostrum contain growth factors such as insulin-like growth factor IGF-I, IGF-II, transforming growth factor TGF-β1, TGF-β2, epidermal growth factor EGF, basic fibroblast growth factor bFGF and platelet-derived growth factor PDGF.
Fernanda Lopes da Silva +3 more
doaj +1 more source
Journal of Cell Biology, 1993 Granulation tissue fibroblasts (myofibroblasts) develop several ultrastructural and biochemical features of smooth muscle (SM) cells, including the presence of microfilament bundles and the expression of alpha-SM actin, the actin isoform typical of ...
Alexis Desmoulière +3 more
semanticscholar +1 more source
Polymorphism in TGFB1 is associated with worse non-relapse mortality and overall survival after stem cell transplantation with unrelated donors. [PDF]
, 2015 Transforming growth factor beta-1, encoded by the TGFB1 gene, is a cytokine that plays a central role in many physiological and pathogenic processes.
Apperley, JF +13 more
core +2 more sources
Expression of transforming growth factor beta in oral submucous fibrosis
Journal of Oral Biology and Craniofacial Research, 2020 Background: Oral submucous fibrosis (OSMF) is a premalignant condition mainly caused by areca nut chewing and is characterized by progressive fibrosis of submucosal tissues and epithelial atrophy.
Arpita Rai +5 more
doaj +1 more source
A mathematical model quantifies proliferation and motility effects of TGF--$\beta$ on cancer cells [PDF]
, 2008 Transforming growth factor (TGF) $\beta$ is known to have properties of both a tumor suppressor and a tumor promoter. While it inhibits cell proliferation, it also increases cell motility and decreases cell--cell adhesion.
Arteaga, Carlos L. +6 more
core +3 more sources
Tumor Biology, 2017 Fibroblasts play a central role in tumor invasion, recurrence, and metastasis in head and neck squamous cell carcinoma. The aim of this study was to investigate the influence of tumor cell self-produced factors and paracrine fibroblast–secreted factors ...
Veronika Maria Metzler +8 more
doaj +1 more source
Transforming growth factor-beta and the glomerular filtration barrier
Kidney Research and Clinical Practice, 2013 The increasing burden of chronic kidney disease worldwide and recent advancements in the understanding of pathologic events leading to kidney injury have opened up new potential avenues for therapies to further diminish progression of kidney disease by ...
Ayesha Ghayur, Peter J. Margetts
doaj +1 more source