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Transforming growth factor‐beta 3.
Cell Biology International, 1995ABSTRACTTransforming Growth Factor‐Beta (TGF‐β) is the general name for a family of naturally‐occurring polypeptides which have multiple regulatory effects on cell proliferation and differentiation. Over the last decade it has become apparent that TGF‐βs can be produced by most cell types and exert a wide range of effects in a context‐dependent ...
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British Medical Bulletin, 1989
Since its discovery as a factor able to induce phenotypic transformation with transforming growth factor alpha, transforming growth factor beta (TGF beta) has been found to have unexpectedly widespread and frequently, seemingly paradoxical effects on a variety of cell types.
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Since its discovery as a factor able to induce phenotypic transformation with transforming growth factor alpha, transforming growth factor beta (TGF beta) has been found to have unexpectedly widespread and frequently, seemingly paradoxical effects on a variety of cell types.
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Transforming Growth Factor Beta in Fracture Repair
Clinical Orthopaedics and Related Research, 1998Transforming growth factor betas are a group of polypeptide growth factors that have a wide range of activities in the musculoskeletal and immunological systems. They are thought to play an important role in the development, induction, and repair of bone.
M P, Bostrom, P, Asnis
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Transforming growth factor betas in mammalian embryogenesis
Progress in Growth Factor Research, 1990Type beta transforming growth factors (TGF beta s) are members of a large superfamily of related proteins, each of which plays a pivotal role in embryonic processes. The TGF beta s per se are at least five in number, though only three isoforms have been identified in mammals.
Akhurst, Rosemary J. +4 more
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Transforming growth factor beta: Relevance to radiotherapy
Clinical Oncology, 1995supporting evidence, both from animal work and from clinical findings, to implicate TGFfi in the pathogenesis of radiofibrosis. Animal studies have shown an association between TGFfi levels and radiation fibrosis. In rat liver, the percentage of hepatocytes staining strongly positive for TGFfi after radiation correlates with the extent of subsequent ...
C C, Parker, J R, Yarnold
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What is transforming growth factor-beta (TGF-β)?
British Journal of Plastic Surgery, 2004The TGF-beta superfamily of proteins produces a wide range of frequently opposing effects in different cells and tissues in the body. However, its activation and mode of action are only partially understood because of its complexity in structure and functions and the variability in its downstream targets.
Chin, David +3 more
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Urology, 2008
The mouse renal cell carcinoma line, Renca, is insensitive to transforming growth factor-beta (TGF-beta) in vitro. The present study was conducted to determine whether removal of TGF-beta from these tumor cells would inhibit tumor progression in vivo.TGF-beta elimination was accomplished either by administration of neutralizing TGF-beta antibody into ...
Kent, Perry +11 more
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The mouse renal cell carcinoma line, Renca, is insensitive to transforming growth factor-beta (TGF-beta) in vitro. The present study was conducted to determine whether removal of TGF-beta from these tumor cells would inhibit tumor progression in vivo.TGF-beta elimination was accomplished either by administration of neutralizing TGF-beta antibody into ...
Kent, Perry +11 more
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Transforming Growth Factor Beta and Prostate Cancer
2005The TGF-beta superfamily is the most versatile considering the ability of its members to regulate proliferation, growth arrest, differentiation, and apoptosis of prostatic stromal and epithelial cells as well as the formation of osteoblastic metastases.
Brian, Zhu, Natasha, Kyprianou
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The Journal of Immunology, 1991
Abstract Participation of human polymorphonuclear neutrophils in the inflammatory response is mediated, in part, by soluble factors such as chemotactic peptides and cytokines. Although the cytokine, transforming growth factor beta (TGF-beta), has been shown to recruit monocytes and promote the inflammatory process, its effects on ...
M E, Brandes +3 more
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Abstract Participation of human polymorphonuclear neutrophils in the inflammatory response is mediated, in part, by soluble factors such as chemotactic peptides and cytokines. Although the cytokine, transforming growth factor beta (TGF-beta), has been shown to recruit monocytes and promote the inflammatory process, its effects on ...
M E, Brandes +3 more
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Transforming growth factor β and cancer
Cancer Treatment Reviews, 1995Udgivelsesdato: 1995 ...
Nørgaard, P +3 more
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