Results 21 to 30 of about 523,619 (399)

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

Genes & Development, 1994
Cell-cell contact and TGF-beta can arrest the cell cycle in G1. Mv1Lu mink epithelial cells arrested by either mechanism are incapable of assembling active complexes containing the G1 cyclin, cyclin E, and its catalytic subunit, Cdk2.
K. Polyak, J. Kato, M. Solomon, C. Sherr, J. Massagué, James M. Roberts, A. Koff   +6 more
semanticscholar   +1 more source

Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma

Cells, 2019
Cholangiocarcinoma is a deadly cancer worldwide, associated with a poor prognosis and limited therapeutic options. Although cholangiocarcinoma accounts for less than 15% of liver primary cancer, its silent nature restricts early diagnosis and prevents ...
Panagiotis Papoutsoglou, Corentin Louis, Cédric Coulouarn   +2 more
doaj   +1 more source

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth

Journal of Experimental Medicine, 1986
This study examines the potential role of transforming growth factor beta (TGF-beta) in the regulation of human T lymphocyte proliferation, and proposes that TGF-beta is an important autoregulatory lymphokine that limits T lymphocyte clonal expansion ...
J. Kehrl, L. Wakefield, A. Roberts, S. Jakowlew, M. Alvarez-Mon, R. Derynck, M. Sporn, A. Fauci   +7 more
semanticscholar   +1 more source

Two mutations in the transforming growth factor beta-induced gene associated with familial Lattice corneal dystrophy

International Journal of Ophthalmology, 2017
AIM: To report a phenotypic variant pedigree of lattice corneal dystrophy (LCD) associated with two mutations, R124C and A546D, in the transforming growth factor beta-induced gene (TGFBI).
Wen-Ping Cao,
doaj   +1 more source

TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid [PDF]

, 2012
Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment ...
Abdul HM, Alice L. Yu, Aslan M, Bilska A, Buniatian GH, Cabell L, Carini M, Chong MS, Esposito G, Fuchshofer R, Fuchshofer R, Fukuchi T, Furuyoshi N, Gaitanaki C, Hatten ME, He S, Hernandez MR, Hernandez MR, Hernandez MR, Hernandez MR, Hodges NJ, Ihnat MA, Izzotti A, Jerome Moriniere, Kobayashi S, Kumar DM, Lambert W, Louhelainen M, Lutjen-Drecoll E, Malone PE, Markesbery WR, Meldrum B, Mozaffarieh M, Neufeld AH, Neumann C, Ohia SE, Oksala NK, Oksala NK, Pena JD, Picht G, Proell V, Ridet JL, Sacca SC, Salinthone S, Samali A, Sharp FR, Shin JH, Smith AR, Sturrock A, Tezel G, Tezel G, Tripathi RC, Ulrich Welge-Lussen, Valencia A, Veach J, Várkonyi T, Yang KL, Yang P, Yu AL, Yu AL, Zimmer DB   +60 more
core   +1 more source

The role of transforming growth factor beta in tertiary dentinogenesis

Dental Journal, 2008
The most visible repair response to pulp injury is the deposition of a tertiary dentin matrix over the dentinal tubules of the primary or secondary dentin.
Tetiana Haniastuti, Phides Nunez, Ariadna A. Djais   +2 more
doaj   +1 more source

A Novel Megakaryocyte Subpopulation Poised to Exert the Function of HSC Niche as Possible Driver of Myelofibrosis

Cells, 2021
Careful morphological investigations, coupled with experimental hematology studies in animal models and in in vitro human cultures, have identified that platelets are released in the circulation by mature megakaryocytes generated by hematopoietic stem ...
Anna Rita Migliaccio
doaj   +1 more source

Bone remodeling at microscrew interface near extraction site in the beagle dog mandible-histologic and immunohistochemical analyses

Journal of Applied Oral Science, 2013
Extraction is often used as part of orthodontic therapy, and good control of anchorage is a key step after extraction. Although microscrews can be implanted close to the extraction site in order to achieve orthodontic support, the efficiency of bone ...
Guangxi Wei, Yun Hu, Leilei Zheng, Jinfeng Huo, Tian Tang, Feng Deng   +5 more
doaj   +1 more source

Transforming growth factor beta 1 is associated with subclinical carotid atherosclerosis in patients with systemic lupus erythematosus

Arthritis Research & Therapy, 2023
Background Transforming growth factor beta (TGF-β1) is a multifunctional cytokine that has anti-inflammatory and immunosuppressive effects. TGF-β1 has been linked to cardiovascular disease in the general population. The immunosuppressive effect of TGF-β1
Fuensanta Gómez-Bernal, Juan Carlos Quevedo-Abeledo, María García-González, Yolanda Fernández-Cladera, Agustín F. González-Rivero, Candelaria Martín-González, Miguel Á. González-Gay, Iván Ferraz-Amaro   +7 more
doaj   +1 more source

بررسی اثر کلسترول بر فعال‌سازی مسیر سیگنالینگ TGF-β / Smad3C در سلول‌های ستاره‌ای کبد و نقش آن در پیشرفت فیبروژنز کبدی [PDF]

مجله دانشکده پزشکی اصفهان, 2021
مقدمه: فیبروز کبدی، اغلب به فعال شدن سلول‌های ستاره‌ای کبد (Hepatic stellate cells یا HSCs) و تشکیل بیش از حد زخم در کبد نسبت داده می‌شود؛ چرا که این سلول‌ها باعث تولید بیش از حد ماتریکس خارج سلولی می‌شوند.
doaj   +1 more source