Results 81 to 90 of about 523,619 (399)

Androgens Accentuate TGF‐β Dependent Erk/Smad Activation During Thoracic Aortic Aneurysm Formation in Marfan Syndrome Male Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Male patients with Marfan syndrome have a higher risk of aortic events and root dilatation compared with females. The role androgens play during Marfan syndrome aneurysm development in males remains unknown.
Yasushi Tashima, Hao He, Jason Z. Cui, Albert J. Pedroza, Ken Nakamura, Nobu Yokoyama, Cristiana Iosef, Grayson Burdon, Tiffany Koyano, Atsushi Yamaguchi, Michael P. Fischbein   +10 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Transforming growth factor-beta stimulation of lung fibroblast prostaglandin E2 production. [PDF]

, 1989
Transforming growth factor-beta (TGF beta) stimulated the production of total protein, collagen, and fibronectin by normal human lung fibroblasts.
Diaz, Arturo, Jimenez, Sergio A., Varga, John   +2 more
core   +1 more source

Severe aortic and arterial aneurysms associated with a TGFBR2 mutation. [PDF]

, 2007
BACKGROUND: A 24-year-old man presented with previously diagnosed Marfan\u27s syndrome. Since the age of 9 years, he had undergone eight cardiovascular procedures to treat rapidly progressive aneurysms, dissection and tortuous vascular disease involving ...
A De Paepe, B Loeys, BL Loeys, CS Ki, Dianna M Milewicz, DM Milewicz, E Disabella, G Collod, H Dietz, H Pannu, Hariyadarshi Pannu, HC Dietz, J Furlong, Joseph S Coselli, K Kainulainen, LC Ades, Scott A LeMaire, SN Hasham, Stacey A Carter, T Mizuguchi, VA McKusick, Van Tran-Fadulu   +21 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Gastric pseudoaneurysm in the setting of Loey’s Dietz Syndrome [PDF]

, 2012
Loey’s Dietz syndrome is a disorder of connective tissue caused by a mutation in the genes that encode transforming growth factor (TGF) beta receptor 1 and 2.
Johston, Troy Alan, Likes, Maggie L.
core   +1 more source

Transforming growth factor-beta targets Formin-like 2 for Angiopoietin-like 4 secretion during the epithelial mesenchymal transition [PDF]

, 2019
Epithelial to Mesenchymal transition (EMT) is a highly dynamic process that plays a crucial role in tumor progression and metastasis. While remodelling of the actin cytoskeleton is a hallmark of EMT, the responsible actin regulating factors are less well
Moussi, Christel Jessica
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Targeting transforming growth factor-β signaling [PDF]

Current Opinion in Oncology, 2007
Most cancers are characterized by excessive transforming growth factor-beta production by tumors, which can promote tumor growth and mediate epithelial-to-mesenchymal transition. Transforming growth factor-beta also has the ability to overproduce extracellular matrix components in response to injury and other stimuli.
Michael, Pennison, Boris, Pasche
openaire   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source