Results 51 to 60 of about 53,894 (256)

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

Do Transgenerational Epigenetic Inheritance and Immune System Development Share Common Epigenetic Processes?

Journal of Developmental Biology, 2021
Epigenetic modifications regulate gene expression for development, immune response, disease, and other processes. A major role of epigenetics is to control the dynamics of chromatin structure, i.e., the condensed packaging of DNA around histone proteins ...
Rwik Sen, Christopher Barnes
doaj   +1 more source

Sitting in Many Camps—Innovative Approaches and Methods for First Nations‐Led Research Into Indigenous Peacebuilding

Australian Journal of Social Issues, EarlyView.
ABSTRACT In 2021, a desktop review was conducted of published references to First Nations peoples' approaches to conflict and its management in Australia (Project Stage One), culminating in a report published in 2024. This article focuses on Project Stage Two, a complex, innovative research undertaking building on the findings of Stage One, and being ...
Helen Bishop, Alysoun Boyle, Tania Sourdin, Bin Li   +3 more
wiley   +1 more source

Maternal Priming of Offspring Immune System in Drosophila

G3: Genes, Genomes, Genetics, 2020
Immune priming occurs when a past infection experience leads to a more effective immune response upon a secondary exposure to the infection or pathogen.
Julianna Bozler, Balint Z. Kacsoh, Giovanni Bosco   +2 more
doaj   +1 more source

Transgenerational Transcriptomic and DNA Methylome Profiling of Mouse Fetal Testicular Germline and Somatic Cells after Exposure of Pregnant Mothers to Tributyltin, a Potent Obesogen

Metabolites, 2022
Obesogens such as tributyltin (TBT) are xenobiotic compounds that promote obesity, in part by distorting the normal balance of lipid metabolism. The obesogenic effects of TBT can be observed in directly exposed (F1 and F2 generations) and also subsequent
Keiko Shioda, Junko Odajima, Bruce Blumberg, Toshi Shioda   +3 more
doaj   +1 more source

Hyperosmotic priming of arabidopsis seedlings establishes a long-term somatic memory accompanied by specific changes of the epigenome [PDF]

, 2013
<p>Background: In arid and semi-arid environments, drought and soil salinity usually occur at the beginning and end of a plant's life cycle, offering a natural opportunity for the priming of young plants to enhance stress tolerance in mature plants.
Amtmann, A., Colot, V., Herzyk, P., Perrella, G., Sani, E.   +4 more
core   +1 more source

Shaping research in marine functional connectivity for integrated and effective marine science and management

Biological Reviews, EarlyView.
ABSTRACT Effective knowledge of ecological connectivity at sea and at the land–sea interface is key to supporting global policy goals to conserve and restore ocean biodiversity and function. However, a persistent lack of commonality in terminology and understanding around the concept of connectivity in marine ecological studies hampers its integration ...
Audrey M. Darnaude, Susanne E. Tanner, Andreu Blanco, Anna M. Sturrock, Yael Teff Seker, Angel Pérez‐Ruzafa, Jonne Kotta, Tamar Guy‐Haim, Francisco R. Barboza, Manuel Hidalgo, Katell Guizien, Jerneja Penca, Lucía López‐López, Maria Beger, Federica Costantini, Sophie Arnaud‐Haond, Cynthia Riginos, Kris Hostens, Gil Rilov, Stelios Katsanevakis, Ewan Hunter   +20 more
wiley   +1 more source

Estrogen Receptor-Related DNA and Histone Methylation May Be Involved in the Transgenerational Disruption in Spermatogenesis by Selective Toxic Chemicals

Frontiers in Pharmacology, 2019
Air pollution is a global threat to human health especially spermatogenesis. Animal and epidemiological studies suggest that epigenetic factors can transmit the pathologies transgenerationally.
Xiao Han, Xiao Han, Pengfei Zhang, Wei Shen, Yong Zhao, Yong Zhao, Hongfu Zhang   +6 more
doaj   +1 more source

Epigenetic Information-Body Interaction and Information-Assisted Evolution from the Perspective of the Informational Model of Consciousness [PDF]

, 2019
Introduction: the objective of this investigation is to analyses the advances of understanding in the epigenetic processes and to extract conclusions concerning the information-based evolution from the perspective of the Informational Model of
Gaiseanu, Florin
core  

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source