SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
Advanced Science, EarlyView.During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong +9 more
wiley +1 more source
Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice. [PDF]
, 1994 Jian Wu +5 more
openalex +1 more source
Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis. [PDF]
, 2002 BAUMANN, H +6 more
core +2 more sources
Advanced Science, EarlyView.This work unravels a novel function of CD103+ T cells in eradicating oxidative‐stressed somatic cells to prevent lung tumorigenesis and identifies specific CD103+ T cell‐decline as a key feature in the aged lung. This comprehensive study highlights the contribution of immuno‐dysregulation to the high incidence of aging‐associated lung cancers ...
Yu Xu +7 more
wiley +1 more source
Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label
Advanced Science, EarlyView.The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong +11 more
wiley +1 more source
Glucocorticoid regulation of mouse mammary tumor virus sequences in transgenic mice.
, 1985 Susan R. Ross, Davor Solter
openalex +1 more source
Polyamines and regulation of spermatogenesis: selective stimulation of late spermatogonia in transgenic mice overexpressing the human ornithine decarboxylase gene. [PDF]
, 1993 Harri Hakovirta +6 more
openalex +1 more source
Near‐Freezing‐Temperature Golgi Neuronal Staining for X‐ray Imaging of Human Brain
Advanced Science, EarlyView.A near‐freezing temperature staining strategy, combined with a mercury chloride‐based method, effectively preserves delicate neuronal structures in post‐mortem frozen human brain tissues by minimizing autolysis. This approach enables uniform labeling across centimeter‐scale slices and, when integrated with synchrotron‐based X‐ray microscopy, achieves ...
Feng Zhou +12 more
wiley +1 more source
Severe enterovirus A71 pathogenesis and immune responses in human nucleolin transgenic mice. [PDF]
Med Microbiol ImmunolHsiao NE +9 more
europepmc +1 more source
The maedi-visna virus Tat protein induces multiorgan lymphoid hyperplasia in transgenic mice [PDF]
, 1994 Christine Vellutini +8 more
openalex +1 more source