Results 181 to 190 of about 1,644,173 (317)

Transgenic mice expressing human sickle hemoglobin are partially resistant to rodent malaria [PDF]

, 1993
HL Shear, EF Jr Roth, ME Fabry, FD Costantini, A Pachnis, A Hood, RL Nagel   +6 more
openalex   +1 more source

Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer

Advanced Science, EarlyView.
An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou, Cheng‐Wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley M. Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro E. Gerges, Mason D. Flores, Han Li, Li‐Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel J. McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng   +30 more
wiley   +1 more source

Severe enterovirus A71 pathogenesis and immune responses in human nucleolin transgenic mice. [PDF]

Med Microbiol Immunol
Hsiao NE, Wang YF, Lin YC, Chou WT, Hsu LJ, Wang SM, Wang JR, Lai MD, Chen SH, Chang CF.   +9 more
europepmc   +1 more source

Methylation state of the human HLA‐DRA gene in T‐lymphocytes and B‐lymphocytes of transgenic mice [PDF]

, 1993
Giordana Feriotto, Laura POZZI, Alessandra CIUCCI, Grazia Camarda, Carlo Mischiati, Igea D’Agnano, Roberto Gambari, Patrizio Giacomini   +7 more
openalex   +1 more source

Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension

Advanced Science, EarlyView.
H4R and its downstream TRPV1 channel mediate the excitatory effect of TMN histaminergic afferent inputs on GABAergic sympathoinhibitory neurons in RVMM. Intranasal delivery of selective H4R agonist VUF 8430 suppresses renal sympathetic outflow and elicits sustained depressor and bradycardia responses in SHRs and CUMS‐induced hypertensive rats ...
Ying Shi, Yang‐Xun Zhang, Jun‐Yi Chen, Sai Ma, Wei‐Xuan Xue, Wei Li, Qian‐Xiao Li, Bo Song, Ya‐Ting Li, Hong‐Yu Ma, Shu‐Tao Xie, Hong‐Zhao Li, Di‐Jun Chen, Qi‐Peng Zhang, Hui‐Jie Ma, Jian‐Jun Wang, Lei Yu, Xiao‐Yang Zhang, Jing‐Ning Zhu   +18 more
wiley   +1 more source

Correction: High-fat diet activates pyroptosis of retinal pigment epithelial cells in aged TgAPPswePS1 transgenic mice. [PDF]

Eur J Med Res
Cao J, Li J, Zheng H, Dong Z.
europepmc   +1 more source

Hepatic KLF9 Deficiency Inhibits Dehydroepiandrosterone (DHEA)‐Induced Polycystic Ovary Syndrome via Liver‐Ovary Axis

Advanced Science, EarlyView.
The study shows that liver is a previously unrecognized extraovarian organ that plays a key role about androgen homeostasis in the development of DHEA‐induced PCOS. DHEA is the most common precursor of active androgen, such as DHT, and KLF9 is required for the conversion of DHEA to DHT and hepatic KLF9 might be a potential therapeutic target for PCOS ...
Jianli Song, Zhaoqing Guan, Guiyi Ji, Jing Wang, Xiurui Yan, Yujie Zhang, Yinliang Zhang, Chunfang Ha, Rong Hu, Yongsheng Chang, Yaolin Zhang, Heng Fan   +11 more
wiley   +1 more source

Retraction Note: Glimepiride mitigates tauopathy and neuroinflammation in P301S transgenic mice: role of AKT/GSK3β signaling. [PDF]

Inflammopharmacology
Zaki MO, El-Desouky S, Elsherbiny DA, Salama M, Azab SS.   +4 more
europepmc   +1 more source

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. [PDF]

, 1991
Jeanne Keffer, Lesley Probert, Haris Cazlaris, Spiros Georgopoulos, E Kaslaris, D Kioussis, George Kollias   +6 more
openalex   +1 more source

Synergistic Promotion of Triple‐Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella‐Derived Glutamate and Platelet Activation

Advanced Science, EarlyView.
Polystyrene nanoplastics (PS‐NPs) administered via oral exposure accelerate triple‐negative breast cancer (TNBC) progression by synergistically modulating gut microbiota‐derived glutamate production and platelet activation. This study uncovers a pivotal crosstalk between microbial metabolites and platelet‐tumor interactions, offering mechanistic ...
Leilei Zhu, Peihao Xu, Mingyuan Zhou, Kewei Li, Shasha Tian, Xuemei Fan, Junling Liu, Baodong Ye, Zhishan Ding, Yingzhi Shen   +9 more
wiley   +1 more source