Results 11 to 20 of about 1,644,173 (317)
Disease Models & Mechanisms, 2016 By whole exome sequencing, we recently identified a missense mutation (p.R703C) in the human ATP4a gene, which encodes the proton pump responsible for gastric acidification.
Oriol Calvete +11 more
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Approaches for timeline reductions in pathogenesis studies using genetically modified mice
Microbiology Spectrum, 2023 Although genetically modified mouse models have long been a powerful tool for microbiology research, the manipulation of the mouse genome is expensive, time consuming, and has historically remained the domain of dedicated animal facilities.
Samantha Skavicus, Nicholas S. Heaton
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Non-selective calcium channel blocker bepridil decreases secondary pathology in mice after photothrombotic cortical lesion. [PDF]
PLoS ONE, 2013 Experimental studies have identified a complex link between neurodegeneration, β-amyloid (Aβ) and calcium homeostasis. Here we asked whether early phase β-amyloid pathology in transgenic hAPPSL mice exaggerates the ischemic lesion and remote secondary ...
Anu Lipsanen +6 more
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Human apoB contributes to increased serum total apo(a) level in
Lipids in Health and Disease, 2004 Background The Lp(a) lipoprotein (Lp(a)) consists of the polymorphic glycoprotein apolipoprotein(a) (apo(a)), which is attached by a disulfide bond to apolipoprotein B (apoB).
Teivainen Päivi A +4 more
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Cthrc1 is a positive regulator of osteoblastic bone formation. [PDF]
PLoS ONE, 2008 Bone mass is maintained by continuous remodeling through repeated cycles of bone resorption by osteoclasts and bone formation by osteoblasts. This remodeling process is regulated by many systemic and local factors.We identified collagen triple helix ...
Hiroaki Kimura +8 more
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Journal of Integrative Agriculture, 2016 Myostatin, a member of the transforming growth factor beta (TGF-β) superfamily, is a dominant inhibitor that acts to limit skeletal muscle growth and development.
Li-li QIAN +8 more
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Comparison of mouse species in an in vivo sars-cov-2 challenge model [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2023 The K18-hACE2 transgenic mice, a model animal having human ACE receptors, is employed in studies against the SARS-CoV-2 virus all over the world. Aged Balb/C mice utilized during the SARS-CoV outbreak were compared to non-T-cell, immunosuppressive Nude ...
Hivda ULBEGI POLAT
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Retinoblastoma in transgenic mice
Nature, 1990 Retinoblastoma, a malignancy of the eye occurring in young children, has been widely studied as a model for genetic predisposition to cancer. This disease is caused by mutations in both alleles of an anti-oncogene (the retinoblastoma gene, Rb) that inactivate or eliminate the Rb encoded protein, p105Rb (refs 1 and 2).
Windle, J.J. +6 more
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MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundCardiac stress can trigger production of a 40‐kDa peptide fragment derived from the amino terminus of the cardiac myosin‐binding protein C.
Qinghang Meng +9 more
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Neurobiology of Disease, 2008 Wild-type and single-transgenic (APP, PS1) and double-transgenic (APP+PS1) mice were studied at three different (3-, 12-, and 18-month-old) age periods.
A. Gruart +3 more
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