Results 31 to 40 of about 2,944,144 (312)

Experimental approaches to study cerebral amyloidosis in a transgenic mouse model of Alzheimer's disease [PDF]

, 2004
Misfolding, aggregation and the accumulation of proteins in the brain are common characteristics of diverse age-related neurodegenerative diseases. Each of these neurodegenerative diseases is associated with abnormalities in the folding of a different
Meyer-Lühmann, Melanie
core   +1 more source

Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor. [PDF]

PLoS ONE, 2010
Soluble leptin receptor (OBRe), one of several leptin receptor isoforms, is the only bona fide leptin binding protein in plasma. Our earlier studies demonstrated that OBRe modulates leptin levels in circulation.
Phing-How Lou, Guoqing Yang, Lu Huang, Yunxia Cui, Tiffany Pourbahrami, George K Radda, Cai Li, Weiping Han   +7 more
doaj   +1 more source

Neuropathology in mice expressing mouse alpha-synuclein [PDF]

, 2011
?-Synuclein (?SN) in human is tightly linked both neuropathologically and genetically to Parkinson's disease (PD) and related disorders. Disease-causing properties in vivo of the wildtype mouse ortholog (m?SN), which carries a threonine at position 53 ...
Kahle, Philipp J., Ksiazek, Iwona, Derya R Shimshek, Markus A Ruegg, Rieker Claus, Cindy Boden, Ruegg Markus A., Derya R. Shimshek, Dev, Kumlesh K., Simone Danner, Heinrich Schell, Herman van der Putten, Claus Rieker, Ruegg, Markus A., Philipp J Kahle, Iwona Ksiazek, Boden Cindy, Kumlesh K Dev, Sabine Kauffmann, Schell, Heinrich, van der Putten Herman, Kauffmann Sabine, Dev Kumlesh K., Kumlesh K. Dev, Shimshek, Derya R., Lehnhoff Katja, Ksiazek Iwona, Katja Lehnhoff, Shimshek Derya R., Schell Heinrich, Rieker, Claus, Samuel Barbieri, Philipp J. Kahle, van der Putten, Herman, Kauffmann, Sabine, Lehnhoff, Katja, Markus A. Ruegg, Kahle Philipp J., Danner, Simone, Barbieri, Samuel, Danner Simone, Boden, Cindy, Barbieri Samuel   +42 more
core   +2 more sources

Factors Affecting Production Efficiency of Bacterial Artificial Chromosome Transgenic Mice

Shiyan dongwu yu bijiao yixue, 2021
ObjectiveBy comparing some key factors in generating bacterial artificial chromosome (BAC) transgenic mice, such as the background of strains, the concentration of the BAC DNA used for injection, the size of the BAC DNA, and the storage time of the BAC ...
WANG Qianqian, WANG Wei, LIU Rui, WEI Zhen, LIU Chong   +4 more
doaj   +1 more source

Murine models of renal disease: Possibilities and problems in studies using mutant mice [PDF]

, 2000
The elucidation of the pathogenesis of human renal disease at the molecular level has been facilitated by the growing field of gene targeting and the development of mouse strains with single-gene deletions - the `knock-out' mice. Experimental nephrology,
Anders, Hans-Joachim, Schlöndorff, Detlef   +1 more
core   +1 more source

Mice Transgenic for the Human Carcinoembryonic Antigen Gene Maintain Its Spatiotemporal Expression Pattern [PDF]

, 1994
The tumor marker carcinoembryonic antigen (CEA) is predominantly expressed in epithelial cells along the gastrointestinal tract and in a variety of adenocarcinomas.
Hirth, Antje, Eades-Perner, Anne-Marie, Neumaier, Michael, Zimmermann, Wolfgang, Putten, Herman van der, Thompson, John A., Kleist, Sabine von   +6 more
core   +1 more source

Functional Genomics for the Identification of Modulators of Platelet-Dependent Thrombus Formation

TH Open, 2018
Despite the absence of the genome in platelets, transcription profiling provides important insights into platelet function and can help clarify abnormalities in platelet disorders.
Elien Vermeersch, Benedicte P. Nuyttens, Claudia Tersteeg, Katleen Broos, Simon F. De Meyer, Karen Vanhoorelbeke, Hans Deckmyn   +6 more
doaj   +1 more source

Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels [PDF]

, 2013
The objective of this study was to investigate the effects of modulating brain amyloid-b (Ab) levels at different stages of amyloid pathology on synaptic function, inflammatory cell changes and hippocampal neurogenesis, i.e.
Nordberg, A,, Carina M Thomé, Greig, NH, Greig, Nigel H, Thomé, Carina M, Anna M Lilja, Marutle, Amelia, Daniel Gonzalez, Gonzalez, D, Marutle, A,, Lilja, AM, Amelia Marutle, Röjdner, Jennie, Gonzalez, Daniel, Rojdner, J, Elisa Storelli, Storelli, E, Jennie Röjdner, Unger-Lithner, C, Nordberg, Agneta, Tamanna Mustafiz, Mustafiz, T,, Christina Unger-Lithner, Nigel H Greig, Thome, CM, Mustafiz, Tamanna, Lilja, Anna M, Unger-Lithner, Christina, Storelli, Elisa, Agneta Nordberg   +29 more
core   +2 more sources

KSHV Latency Locus Cooperates with Myc to Drive Lymphoma in Mice.

PLoS Pathogens, 2015
Kaposi sarcoma-associated herpesvirus (KSHV) has been linked to Kaposi sarcoma and B-cell malignancies. Mechanisms of KSHV-induced oncogenesis remain elusive, however, in part due to lack of reliable in vivo models.
Sang-Hoon Sin, Yongbaek Kim, Anthony Eason, Dirk P Dittmer   +3 more
doaj   +1 more source

The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer’s disease

Journal of Neuroinflammation, 2020
Background Tau hyper-phosphorylation has been considered a major contributor to neurodegeneration in Alzheimer’s disease (AD) and related tauopathies, and has gained prominence in therapeutic development for AD.
Yao Sun, Yongqing Guo, Xuejian Feng, Meng Jia, Ning Ai, Yue Dong, Yayuan Zheng, Lu Fu, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu, Wei Kong   +13 more
doaj   +1 more source