Results 31 to 40 of about 3,746,688 (357)

Mechanisms underlying the initiation of cerebral betaamyloidosis and neurofibrillary tau pathology : new insights form transgenic mice [PDF]

, 2006
Numerous neurodegenerative disorders result from the aggregation of proteins that misfold and accumulate as fibrillar amyloid deposits in selectively vulnerable regions of the central nervous system.
Bolmont, Tristan
core   +1 more source

Aged wild-type and APP, PS1, and APP+PS1 mice present similar deficits in associative learning and synaptic plasticity independent of amyloid load

Neurobiology of Disease, 2008
Wild-type and single-transgenic (APP, PS1) and double-transgenic (APP+PS1) mice were studied at three different (3-, 12-, and 18-month-old) age periods.
A. Gruart, J.C. López-Ramos, M.D. Muñoz, J.M. Delgado-García   +3 more
doaj   +1 more source

Generation of Fad2 and Fad3 transgenic mice that produce n-6 and n-3 polyunsaturated fatty acids [PDF]

Open Biology, 2019
Linoleic acid (18 : 2, n-6) and α-linolenic acid (18 : 3, n-3) are polyunsaturated fatty acids (PUFAs), which are essential for mammalian health, development and growth.
Lishuang Song, Lei Yang, Jiapeng Wang, Xuefei Liu, Lige Bai, Anqi Di, Guangpeng Li   +6 more
doaj   +1 more source

Lymphoid hyperplasia and lymphoma in transgenic mice expressing the small non-coding RNA, EBER1 of Epstein-Barr virus [PDF]

, 2010
Background. Non-coding RNAs have critical functions in diverse biological processes, particularly in gene regulation. Viruses, like their host cells, employ such functional RNAs and the human cancer associated Epstein-Barr virus (EBV) is no exception ...
Tsimbouri Penelope M., Philbey, A.W., Philbey, Adrian W, Repellin, C.E, Claire E Repellin, Wilson, J.B., Joanna B Wilson, Repellin, Claire E, Tsimbouri, P.M., Wilson Joanna B., Philbey Adrian W., Tsimbouri, Penelope M, Adrian W Philbey, Penelope M Tsimbouri, Wilson, Joanna B, Repellin Claire E.   +15 more
core   +1 more source

Retinoblastoma in transgenic mice

Nature, 1990
Retinoblastoma, a malignancy of the eye occurring in young children, has been widely studied as a model for genetic predisposition to cancer. This disease is caused by mutations in both alleles of an anti-oncogene (the retinoblastoma gene, Rb) that inactivate or eliminate the Rb encoded protein, p105Rb (refs 1 and 2).
Windle, J.J., Albert, D.M., O'Brien, J.M., Marcus, D.M., Disteche, Ch.M., Bernards, R.A., Mellon, P.L.   +6 more
openaire   +3 more sources

Murine models of renal disease: Possibilities and problems in studies using mutant mice [PDF]

, 2000
The elucidation of the pathogenesis of human renal disease at the molecular level has been facilitated by the growing field of gene targeting and the development of mouse strains with single-gene deletions - the `knock-out' mice. Experimental nephrology,
Anders, Hans-Joachim, Schlöndorff, Detlef   +1 more
core   +1 more source

Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor. [PDF]

PLoS ONE, 2010
Soluble leptin receptor (OBRe), one of several leptin receptor isoforms, is the only bona fide leptin binding protein in plasma. Our earlier studies demonstrated that OBRe modulates leptin levels in circulation.
Phing-How Lou, Guoqing Yang, Lu Huang, Yunxia Cui, Tiffany Pourbahrami, George K Radda, Cai Li, Weiping Han   +7 more
doaj   +1 more source

Neuropathology in mice expressing mouse alpha-synuclein [PDF]

, 2011
?-Synuclein (?SN) in human is tightly linked both neuropathologically and genetically to Parkinson's disease (PD) and related disorders. Disease-causing properties in vivo of the wildtype mouse ortholog (m?SN), which carries a threonine at position 53 ...
Kahle, Philipp J., Ksiazek, Iwona, Derya R Shimshek, Markus A Ruegg, Rieker Claus, Cindy Boden, Ruegg Markus A., Derya R. Shimshek, Dev, Kumlesh K., Simone Danner, Heinrich Schell, Herman van der Putten, Claus Rieker, Ruegg, Markus A., Philipp J Kahle, Iwona Ksiazek, Boden Cindy, Kumlesh K Dev, Sabine Kauffmann, Schell, Heinrich, van der Putten Herman, Kauffmann Sabine, Dev Kumlesh K., Kumlesh K. Dev, Shimshek, Derya R., Lehnhoff Katja, Ksiazek Iwona, Katja Lehnhoff, Shimshek Derya R., Schell Heinrich, Rieker, Claus, Samuel Barbieri, Philipp J. Kahle, van der Putten, Herman, Kauffmann, Sabine, Lehnhoff, Katja, Markus A. Ruegg, Kahle Philipp J., Danner, Simone, Barbieri, Samuel, Danner Simone, Boden, Cindy, Barbieri Samuel   +42 more
core   +1 more source

Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance

Neuron, 2015
Summary An increasingly powerful approach for studying brain circuits relies on targeting genetically encoded sensors and effectors to specific cell types. However, current approaches for this are still limited in functionality and specificity.
L. Madisen, Aleena R. Garner, Daisuke Shimaoka, A. Chuong, Nathan C. Klapoetke, Lu Li, A. Bourg, Y. Niino, Ladan Egolf, C. Monetti, Hong Gu, Maya Mills, A. Cheng, Bosiljka Tasic, T. Nguyen, S. Sunkin, A. Benucci, A. Nagy, A. Miyawaki, F. Helmchen, R. Empson, T. Knöpfel, E. Boyden, R. Reid, M. Carandini, Hongkui Zeng   +25 more
semanticscholar   +1 more source

KSHV Latency Locus Cooperates with Myc to Drive Lymphoma in Mice.

PLoS Pathogens, 2015
Kaposi sarcoma-associated herpesvirus (KSHV) has been linked to Kaposi sarcoma and B-cell malignancies. Mechanisms of KSHV-induced oncogenesis remain elusive, however, in part due to lack of reliable in vivo models.
Sang-Hoon Sin, Yongbaek Kim, Anthony Eason, Dirk P Dittmer   +3 more
doaj   +1 more source