Results 11 to 20 of about 1,712,319 (264)

Characterization of Mice Ubiquitously Overexpressing Human 15-Lipoxygenase-1: Effect of Diabetes on Peripheral Neuropathy and Treatment with Menhaden Oil

Journal of Diabetes Research, 2021
To rigorously explore the role of omega-3 polyunsaturated fatty acids (PUFA) in the treatment of diabetic peripheral neuropathy (DPN), we have created a transgenic mouse utilizing a Cre-lox promoter to control overexpression of human 15-lipoxygenase-1 ...
Lawrence Coppey, Alexander Obrosov, Hanna Shevalye, Eric Davidson, William Paradee, Mark A. Yorek   +5 more
doaj   +1 more source

SIRT1 Is Necessary for Proficient Telomere Elongation and Genomic Stability of Induced Pluripotent Stem Cells

Stem Cell Reports, 2014
The NAD-dependent deacetylase SIRT1 is involved in chromatin silencing and genome stability. Elevated SIRT1 levels in embryonic stem cells also suggest a role for SIRT1 in pluripotency.
Maria Luigia De Bonis, Sagrario Ortega, Maria A. Blasco   +2 more
doaj   +1 more source

A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies

Disease Models & Mechanisms, 2016
By whole exome sequencing, we recently identified a missense mutation (p.R703C) in the human ATP4a gene, which encodes the proton pump responsible for gastric acidification.
Oriol Calvete, Andrea Varro, D. Mark Pritchard, Alicia Barroso, Marta Oteo, Miguel Ángel Morcillo, Pierfrancesco Vargiu, Steven Dodd, Miriam Garcia, José Reyes, Sagrario Ortega, Javier Benitez   +11 more
doaj   +1 more source

Human apoB contributes to increased serum total apo(a) level in LPA transgenic mice

Lipids in Health and Disease, 2004
Background The Lp(a) lipoprotein (Lp(a)) consists of the polymorphic glycoprotein apolipoprotein(a) (apo(a)), which is attached by a disulfide bond to apolipoprotein B (apoB).
Teivainen Päivi A, Eliassen Knut A, Rubin Edward M, Djurovic Srdjan, Berg Kåre   +4 more
doaj   +1 more source

Non-selective calcium channel blocker bepridil decreases secondary pathology in mice after photothrombotic cortical lesion. [PDF]

PLoS ONE, 2013
Experimental studies have identified a complex link between neurodegeneration, β-amyloid (Aβ) and calcium homeostasis. Here we asked whether early phase β-amyloid pathology in transgenic hAPPSL mice exaggerates the ischemic lesion and remote secondary ...
Anu Lipsanen, Stefanie Flunkert, Kristina Kuptsova, Mikko Hiltunen, Manfred Windisch, Birgit Hutter-Paier, Jukka Jolkkonen   +6 more
doaj   +1 more source

Cthrc1 is a positive regulator of osteoblastic bone formation. [PDF]

PLoS ONE, 2008
Bone mass is maintained by continuous remodeling through repeated cycles of bone resorption by osteoclasts and bone formation by osteoblasts. This remodeling process is regulated by many systemic and local factors.We identified collagen triple helix ...
Hiroaki Kimura, Kin Ming Kwan, Zhaoping Zhang, Jian Min Deng, Bryant G Darnay, Richard R Behringer, Takashi Nakamura, Benoit de Crombrugghe, Haruhiko Akiyama   +8 more
doaj   +1 more source

Muscle hypertrophy in transgenic mice due to over-expression of porcine myostatin mutated at its cleavage site

Journal of Integrative Agriculture, 2016
Myostatin, a member of the transforming growth factor beta (TGF-β) superfamily, is a dominant inhibitor that acts to limit skeletal muscle growth and development.
Li-li QIAN, De-zun MA, Peng-fei GAO, Sheng-wang JIANG, Qing-qing WANG, Chun-bo CAI, Gao-jun XIAO, Xiao-rong AN, Wen-tao CUI   +8 more
doaj   +1 more source

MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundCardiac stress can trigger production of a 40‐kDa peptide fragment derived from the amino terminus of the cardiac myosin‐binding protein C.
Qinghang Meng, Bidur Bhandary, Hanna Osinska, Jeanne James, Na Xu, Kritton Shay‐Winkler, James Gulick, Monte S. Willis, Cynthia Lander, Jeffrey Robbins   +9 more
doaj   +1 more source

Aged wild-type and APP, PS1, and APP+PS1 mice present similar deficits in associative learning and synaptic plasticity independent of amyloid load

Neurobiology of Disease, 2008
Wild-type and single-transgenic (APP, PS1) and double-transgenic (APP+PS1) mice were studied at three different (3-, 12-, and 18-month-old) age periods.
A. Gruart, J.C. López-Ramos, M.D. Muñoz, J.M. Delgado-García   +3 more
doaj   +1 more source

Generation of Fad2 and Fad3 transgenic mice that produce n-6 and n-3 polyunsaturated fatty acids [PDF]

Open Biology, 2019
Linoleic acid (18 : 2, n-6) and α-linolenic acid (18 : 3, n-3) are polyunsaturated fatty acids (PUFAs), which are essential for mammalian health, development and growth.
Lishuang Song, Lei Yang, Jiapeng Wang, Xuefei Liu, Lige Bai, Anqi Di, Guangpeng Li   +6 more
doaj   +1 more source