Results 21 to 30 of about 1,712,319 (264)
Comparison of mouse species in an in vivo sars-cov-2 challenge model [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2023 The K18-hACE2 transgenic mice, a model animal having human ACE receptors, is employed in studies against the SARS-CoV-2 virus all over the world. Aged Balb/C mice utilized during the SARS-CoV outbreak were compared to non-T-cell, immunosuppressive Nude ...
Hivda ULBEGI POLAT
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Factors Affecting Production Efficiency of Bacterial Artificial Chromosome Transgenic Mice
Shiyan dongwu yu bijiao yixue, 2021 ObjectiveBy comparing some key factors in generating bacterial artificial chromosome (BAC) transgenic mice, such as the background of strains, the concentration of the BAC DNA used for injection, the size of the BAC DNA, and the storage time of the BAC ...
WANG Qianqian +4 more
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Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor. [PDF]
PLoS ONE, 2010 Soluble leptin receptor (OBRe), one of several leptin receptor isoforms, is the only bona fide leptin binding protein in plasma. Our earlier studies demonstrated that OBRe modulates leptin levels in circulation.
Phing-How Lou +7 more
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Retinoblastoma in transgenic mice
Nature, 1990 Retinoblastoma, a malignancy of the eye occurring in young children, has been widely studied as a model for genetic predisposition to cancer. This disease is caused by mutations in both alleles of an anti-oncogene (the retinoblastoma gene, Rb) that inactivate or eliminate the Rb encoded protein, p105Rb (refs 1 and 2).
Windle, J.J. +6 more
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Functional Genomics for the Identification of Modulators of Platelet-Dependent Thrombus Formation
TH Open, 2018 Despite the absence of the genome in platelets, transcription profiling provides important insights into platelet function and can help clarify abnormalities in platelet disorders.
Elien Vermeersch +6 more
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KSHV Latency Locus Cooperates with Myc to Drive Lymphoma in Mice.
PLoS Pathogens, 2015 Kaposi sarcoma-associated herpesvirus (KSHV) has been linked to Kaposi sarcoma and B-cell malignancies. Mechanisms of KSHV-induced oncogenesis remain elusive, however, in part due to lack of reliable in vivo models.
Sang-Hoon Sin +3 more
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Antioxidant properties of HDL in transgenic mice overexpressing human apolipoprotein A-II
Journal of Lipid Research, 2002 Transgenic mice overexpressing human apolipoprotein A-II (huapoA-II) display high VLDL and low HDL levels. To evaluate the antioxidant potential of huapoA-II enriched HDL, we measured the activities of paraoxonase (PON) and platelet-activating factor ...
Elisabeth Boisfer +6 more
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Nerve terminal degeneration is independent of muscle fiber genotype in SOD1 mice. [PDF]
PLoS ONE, 2010 Motor neuron degeneration in SOD1(G93A) transgenic mice begins at the nerve terminal. Here we examine whether this degeneration depends on expression of mutant SOD1 in muscle fibers.Hindlimb muscles were transplanted between wild-type and SOD1(G93A ...
Dario I Carrasco +3 more
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Journal of Neuroinflammation, 2020 Background Tau hyper-phosphorylation has been considered a major contributor to neurodegeneration in Alzheimer’s disease (AD) and related tauopathies, and has gained prominence in therapeutic development for AD.
Yao Sun +13 more
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Function and mechanism of the human SOD2 gene in mice cerebral ischemia/ reperfusion injury [PDF]
Acta Cirúrgica BrasileiraPurpose: To investigate the neuroprotective effects of the SOD2 gene in cerebral ischemia reperfusion injury function and the underlying mechanisms in a mice model of middle cerebral artery ischemia reperfusion.
Xitong Yang, Guangming Wang
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