Human apoB contributes to increased serum total apo(a) level in
Lipids in Health and Disease, 2004 Background The Lp(a) lipoprotein (Lp(a)) consists of the polymorphic glycoprotein apolipoprotein(a) (apo(a)), which is attached by a disulfide bond to apolipoprotein B (apoB).
Teivainen Päivi A +4 more
doaj +1 more source
Non-selective calcium channel blocker bepridil decreases secondary pathology in mice after photothrombotic cortical lesion. [PDF]
PLoS ONE, 2013 Experimental studies have identified a complex link between neurodegeneration, β-amyloid (Aβ) and calcium homeostasis. Here we asked whether early phase β-amyloid pathology in transgenic hAPPSL mice exaggerates the ischemic lesion and remote secondary ...
Anu Lipsanen +6 more
doaj +1 more source
Cerebral amyloid angiopathy : new insights from transgenic mice [PDF]
, 2004 Cerebral amyloid angiopathy (CAA) is characterized by the deposition of congophilic material within the walls of small to medium-sized blood vessels of the brain and leptomeninges.
Herzig, Martin C.
core +1 more source
Cthrc1 is a positive regulator of osteoblastic bone formation. [PDF]
PLoS ONE, 2008 Bone mass is maintained by continuous remodeling through repeated cycles of bone resorption by osteoclasts and bone formation by osteoblasts. This remodeling process is regulated by many systemic and local factors.We identified collagen triple helix ...
Hiroaki Kimura +8 more
doaj +1 more source
MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundCardiac stress can trigger production of a 40‐kDa peptide fragment derived from the amino terminus of the cardiac myosin‐binding protein C.
Qinghang Meng +9 more
doaj +1 more source
Comparison of mouse species in an in vivo sars-cov-2 challenge model [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2023 The K18-hACE2 transgenic mice, a model animal having human ACE receptors, is employed in studies against the SARS-CoV-2 virus all over the world. Aged Balb/C mice utilized during the SARS-CoV outbreak were compared to non-T-cell, immunosuppressive Nude ...
Hivda ULBEGI POLAT
doaj +1 more source
Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen. [PDF]
, 2012 A large fraction of murine tumors induced by transgenic expression of SV40 large T antigen (SV40 TAg) exhibits a neuroendocrine phenotype. It is unclear whether SV40 TAg induces the neuroendocrine phenotype by preferential transformation of progenitor ...
Georg Enders (187983) +32 more
core +1 more source
Journal of Integrative Agriculture, 2016 Myostatin, a member of the transforming growth factor beta (TGF-β) superfamily, is a dominant inhibitor that acts to limit skeletal muscle growth and development.
Li-li QIAN +8 more
doaj +1 more source
Experimental approaches to study cerebral amyloidosis in a transgenic mouse model of Alzheimer's disease [PDF]
, 2004 Misfolding, aggregation and the accumulation of proteins in the brain are common characteristics of diverse age-related neurodegenerative diseases. Each of these neurodegenerative diseases is associated with abnormalities in the folding of a different
Meyer-Lühmann, Melanie
core +1 more source
Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota
Scientific Reports, 2017 Alzheimer’s disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number
T. Harach +10 more
semanticscholar +1 more source