Results 191 to 200 of about 655,970 (311)

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

Advanced NanoBiomed Research, EarlyView.
Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo, Yen‐Tzu Liao, Hsinyu Lee   +2 more
wiley   +1 more source

Transgenic mice applications in the study of endometriosis pathogenesis. [PDF]

Front Cell Dev Biol
Zhao Y, Wang Y, Gu P, Tuo L, Wang L, Jiang SW.   +5 more
europepmc   +1 more source

Proteomic Profiling of the Large‐Vessel Vasculitis Spectrum Identifying Shared Signatures of Innate Immune Activation and Stromal Remodeling

Arthritis &Rheumatology, EarlyView.
Objective Takayasu arteritis (TAK) and giant cell arteritis (GCA), the most common forms of large‐vessel vasculitis (LVV), can result in serious morbidity. Understanding the molecular basis of LVV should aid in developing better biomarkers and treatments. Methods Plasma proteomic profiling of 184 proteins was performed in two cohorts. Cohort 1 included
Robert T. Maughan, Erin Macdonald‐Dunlop, Lubna Haroon‐Rashid, Louise Sorensen, Natalie Chaddock, Shauna Masters, Andrew Porter, Marta Peverelli, Charis Pericleous, Andrew Hutchings, James Robinson, Taryn Youngstein, Raashid A. Luqmani, Justin C. Mason, Ann W. Morgan, James E. Peters   +15 more
wiley   +1 more source

Inflammatory Stimuli and Fecal Microbiota Transplantation Accelerate Pancreatic Carcinogenesis in Transgenic Mice, Accompanied by Changes in the Microbiota Composition. [PDF]

Cells
Świdnicka-Siergiejko A, Daniluk J, Miniewska K, Daniluk U, Guzińska-Ustymowicz K, Pryczynicz A, Dąbrowska M, Rusak M, Ciborowski M, Dąbrowski A.   +9 more
europepmc   +1 more source

Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice. [PDF]

, 1990
Sandra L. Hofmann, Dan Eaton, M S Brown, Walter J. McConathy, Joseph L. Goldstein, Robert E. Hammer   +5 more
openalex   +1 more source

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays, EarlyView.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source

Silencing of the von Willebrand factor gene in proatherothrombotic <i>APOE∗3-Leiden.CETP</i> transgenic mice. [PDF]

Res Pract Thromb Haemost
Jongejan YK, Dirven RJ, Schrader Echeverri E, de Jong AJL, Pronk ACM, Kooijman S, Rensen PCN, Dahlman JE, Eikenboom JCJ, van Vlijmen BJM.   +9 more
europepmc   +1 more source

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

, 1994
Priscilla A. Furth, L St Onge, Hinrich Böger, Peter Gruß, Manfred Gossen, A Kistner, Hermann Bujard, Lothar Hennighausen   +7 more
openalex   +1 more source

Respiratory epithelial cell expression of human transforming growth factor-alpha induces lung fibrosis in transgenic mice. [PDF]

, 1994
Thomas R. Korfhagen, R J Swantz, Susan E. Wert, J M McCarty, C B Kerlakian, Stephan W. Glasser, Jeffrey A. Whitsett   +6 more
openalex   +1 more source

The contribution of extracellular RNA and its derived biomaterials in disease management

BMEMat, EarlyView.
The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei, Zhangyi Wang, Zixuan Qin, Qianqian Wan, Yutao Li, Franklin R. Tay, Chenyu Wang, Tong Zhang, Lina Niu   +8 more
wiley   +1 more source