Results 191 to 200 of about 1,644,173 (317)

Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. [PDF]

BMC Neurosci
Spencer B, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage FH, Verma IM, Masliah E.   +9 more
europepmc   +1 more source

Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice. [PDF]

, 1990
Constanze Bonifer, Miguel Vidal, F. Grosveld, Albrecht E. Sippel   +3 more
openalex   +1 more source

Deficiency of Leucine‐Rich Repeat Containing G Protein‐Coupled Receptor 4 in Pancreas Reduces β Cell Mass

Advanced Science, EarlyView.
In islet β cells, LGR4 binds with Rspondin to activate the Wnt‐β‐catenin‐Ccnd1 axis, leading to a subsequent increase in cell proliferation. On the other hand, LGR4 also binds with RANKL, thus suppressing the phosphorylation of p44/p42 MAPK and p65 NF‐κB and subsequent cell apoptosis.
Chao Luo, Yifan Feng, Jiajie Min, Yan Zhao, Ziming Zhu, Lijun Sun, Hao Yin, Yue Yin, Weizhen Zhang   +8 more
wiley   +1 more source

Exploring the Chemopreventive and Antioxidant Effects of Spearmint Leaf Hydroethanolic Extract in HPV16-transgenic Mice. [PDF]

In Vivo
Jesus TM, Azevedo T, Silva-Reis R, Ferreira T, Nascimento-Gonçalves E, Medeiros C, Ferreira J, Gama A, Gaivão I, Pires MJ, Lanzarin G, Félix L, Venâncio C, Medeiros R, Bastos MMSM, Finimundy TC, Barros L, Gil DA Costa RM, Oliveira PA.   +18 more
europepmc   +1 more source

Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice. [PDF]

, 1990
Chenghui Yan, Robert H. Costa, James Darnell, John D Chen, T A Van Dyke   +4 more
openalex   +1 more source

Acetylation of the Mitochondrial Chaperone GRP75 Governs ER‐Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance

Advanced Science, EarlyView.
Overnutrition exacerbates insulin resistance (IR) and is linked to excessive mitochondrial protein acetylation. However, it remains unclear whether and how mitochondrial protein acetylation influences IR. GCN5L1‐dependent downregulation of GRP75 acetylation at K567/612 consequently enhances ER‐mitochondrial calcium flux and induces ER stress.
Danni Wang, Jiaqi Zhang, Xinyu Yang, Qiqi Zhang, Xiuya Hu, Xin Lu, Hanni Li, Xue Bai, Kai Zhang, Michael N. Sack, Yongsheng Chang, Yingmei Wang, Lingdi Wang, Lu Zhu   +13 more
wiley   +1 more source

An Automated Micro‐Immunobeads‐Based Electromagnetic Operation System (MEMOs) for Blood Testing of Alzheimer's Disease

Advanced Science, EarlyView.
This work presents an automated and accessible point‐of‐care device, MEMOs, for the detection of exosomal Aβ42 protein, a potential blood biomarker for Alzheimer’s disease. MEMOs, with its automated operation workflow, minimizes hands‐on time and maintains high sensitivity in diagnosing AD, allowing non‐specialists to conduct tests at home and offering
Xiaoxue Fan, Xinyu Ye, Jiangrui Xu, Tianjiao Mao, Ruotong Zhang, Xinyuan Zhou, Christina C. K. Au Yeung, Chang Li, Raymond Chuen‐Chung Chang, Haisong Lin, Ho Cheung Shum   +10 more
wiley   +1 more source

High-fat diet activates pyroptosis of retinal pigment epithelial cells in aged TgAPPswePS1 transgenic mice. [PDF]

Eur J Med Res
Cao J, Li J, Zheng H, Dong Z.
europepmc   +1 more source

Metabolic effects of developmental, tissue-, and cell-specific expression of a chimeric phosphoenolpyruvate carboxykinase (GTP)/bovine growth hormone gene in transgenic mice.

, 1990
M.M. McGrane, Jun Seop Yun, Antoon F.M. Moorman, Wouter H. Lamers, G. K. Hendrick, Baha M. Arafah, E A Park, Thomas E. Wagner, Richard W. Hanson   +8 more
openalex   +1 more source

Faecalibaculum rodentium Alleviates Ionizing Radiation‐Induced Damage in Mice by Improving Intestinal Integrity and Hematopoiesis via Its Metabolite Butyrate

Advanced Science, EarlyView.
The model shows the probiotics screening and underlying mechanisms of F. rodentiumn in alleviating IR‐induced tissue injury. Stress‐induced STAT3 mitochondria localization decreases F. rodentium abundance and butyrate concentration. Supplementation of F.
Hanyong Zhu, Hui Guo, Na Sun, Rui Xiao, Binbin Ji, Ruihan Jiang, Fuxing Dong, Chen Yao, Xuerong Wang, Rongqing Li, Jie Zhao, Xueqin Li, Shengzhe Gong, Yongqin Qin, Xin Chen, Yuchen Pan, Takayuki Ikezoe, Jing Yang   +17 more
wiley   +1 more source