Results 281 to 290 of about 655,970 (311)
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Measurement of Anxiety in Transgenic Mice
Reviews in the Neurosciences, 2000A wide range of approaches has been used to study anxiety in mice. All presuppose that aversive stimuli, such as foot shock or novelty, induce a central state of fear, which can be quantified through specific behavioural and physiological measures. This review discusses the validity of the various approaches in terms of their similarity to different ...
Guy Anthony Oakdene Cour Winnersh Kennett +4 more
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The trouble with transgenic mice
Immunology & Cell Biology, 1995SummaryObservations on many antigen‐receptor transgenic models with anti‐self specificities have been interpreted as proof for clonal deletion or for mechanisms involved in clonal deletion. At the same time, there is increasing evidence that many lymphocytes that recognize self exist, are activated and produce end products, even in individuals without ...
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Alzheimer’s disease and transgenic mice
1994Transgenic mice overexpressing the three major neuronal isoforms of the human amyloid precursor protein (APP), APP695, APP751, APP770 may provide an animal model for the analysis of the mechanisms and risk factors leading to amyloid deposition in Alzheimer's disease (AD) and Downs syndrome (DS).
Ch. Czech +2 more
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1997
Publisher Summary Animals carrying new genes are referred to as transgenic. Transgenic animals are unique models that are custom-tailored to address a specific question associated with gene function. One of the more commonly used animals in transgenic techniques is the mouse species, as the methods involving the microinjection of transgenes into the ...
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Publisher Summary Animals carrying new genes are referred to as transgenic. Transgenic animals are unique models that are custom-tailored to address a specific question associated with gene function. One of the more commonly used animals in transgenic techniques is the mouse species, as the methods involving the microinjection of transgenes into the ...
openaire +2 more sources
Transgenic Mice With Immunoglobulin Genes
Annual Review of Immunology, 1987Immunoglobulin (Ig) genes encode antibody molecules expressed exclu sively in the B-Iymphocyte lineage. The most immature identifiable cells of the B-cell lineage, pre-B cells, give rise to B cells that differentiate terminally into antibody secreting plasma cells.
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HBV production in transgenic mice
Gastroenterologia Japonica, 1990We produced transgenic mice by microinjecting a partially duplicated copies of hepatitis B virus (HBV) gene into fertilized eggs of C57BL/6 mice. One mouse was a high producer of HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) in the serum. All offspring carrying HBV DNA were positive for both antigens in the serum.
Okio Hino +5 more
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1989
The induction of mutations in transgenic mice represents a powerful experimental tool as it not only allows the derivation of precise animal models for human hereditary diseases but also permits a systematic genetic dissection of the mammalian genome.
Rudolf Jaenisch +3 more
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The induction of mutations in transgenic mice represents a powerful experimental tool as it not only allows the derivation of precise animal models for human hereditary diseases but also permits a systematic genetic dissection of the mammalian genome.
Rudolf Jaenisch +3 more
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Reporter genes in transgenic mice
Transgenic Research, 1994Although in vivo models utilizing endogenous reporter genes have been exploited for many years, the use of reporter transgenes to dissect biological issues in transgenic animals has been a relatively recent development. These transgenes are often, but not always, of prokaryotic origin and encode products not normally associated with eukaryotic cells ...
Cunqi Cui +4 more
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Transgenic RNA Interference in Mice
Physiology, 2007The discovery that small interfering RNA duplexes (siRNA) can silence gene expression in mammalian cells has revolutionized biomedical research. The most successful application of the discovery has been to study gene function in cultured human or mouse cells. However, the knockdown effect of siRNA is only transient.
Xue Gao, Pumin Zhang
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2012
Although the prion protein (PrP) was discovered in the early 1980s, there is still a considerable lack of knowledge of the normal function of the PrP protein and its precise role in the infectious process of transmissible spongiform encephalopathies (TSEs) or prion diseases.
Jean Manson +5 more
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Although the prion protein (PrP) was discovered in the early 1980s, there is still a considerable lack of knowledge of the normal function of the PrP protein and its precise role in the infectious process of transmissible spongiform encephalopathies (TSEs) or prion diseases.
Jean Manson +5 more
openaire +2 more sources