Results 281 to 290 of about 1,952,729 (355)

Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes

Advanced Science, EarlyView.
In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu, Wenpin Qin, Jialu Gao, Yihan Guo, Xiaoxiao Han, Zhangyu Ma, Xiaokang Zhang, Jie He, Jing Liu, Bo Gao, Changjun Li, Lina Niu, Jianfei Yan, Kai Jiao   +13 more
wiley   +1 more source

Application of Humanized MHC Transgenic Mice in the Screening of HLA-Restricted T Cell Epitopes for Influenza Vaccines. [PDF]

Vaccines (Basel)
Wei Y, Sun K, Han X, Sun Y, Zhang J, Wang Y, Yin Q, Yang T, Yuan K, Li M, Zhao G.   +10 more
europepmc   +1 more source

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, Yeyu Zhang, Gaofeng Shu, Fazong Wu, Jianfei Tu, Minjiang Chen, Zhongwei Zhao, Zhuang Liu, Jiansong Ji   +17 more
wiley   +1 more source

Identification of EcoHIV-Infected Cells in Microglia-Manipulated Transgenic Mice. [PDF]

J Vis Exp
Li H, Walker M, Ji H, Sikirzhytskaya A, Aksenova M, Shtutman M, Sikirzhytski V, Mactutus CF, Booze RM.   +8 more
europepmc   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

AAV-mediated peripheral scFv's administration to reduce cerebral tau in adult P301S transgenic mice: Mono-vs. combination therapy. [PDF]

Mol Ther Methods Clin Dev
Katel S, Cicalo J, Vasciaveo V, Vecchio LM, Carrion J, Mahadeo L, Huerta PT, Choksi JD, Aubert I, Marambaud P, Giliberto L, d'Abramo C.   +11 more
europepmc   +1 more source

Correction to: WIF1 causes dysfunction of heart in transgenic mice. [PDF]

Transgenic Res
Lu D, Dong W, Zhang X, Quan X, Bao D, Lu Y, Zhang L.   +6 more
europepmc   +1 more source

Evaluation of [¹⁸F]F-CNBI and [¹⁸F]F-CNPI PET Probes in GSK-3β Transgenic Mice. [PDF]

ACS Chem Neurosci
Kethamreddy M, Gundam SR, Rivera AG, Bansal A, Lim DY, Giri S, Larson NB, Wootla B, Lowe VJ, Baker DJ, Pandey MK.   +10 more
europepmc   +1 more source

Repetitive mild traumatic brain injury with the closed-head impact model of engineered rotational acceleration (CHIMERA) promotes tau pathology in tau transgenic mice and its propagation in brains injected with tau fibrils. [PDF]

Acta Neuropathol Commun
Kimura T, Masuda-Suzukake M, Hashimoto M, Sekiyama K, Kametani F, Tomita T, Aoyagi H, Hisanaga SI, Hasegawa M.   +8 more
europepmc   +1 more source

Evidence of cortical vascular impairments in early stage of Alzheimer's transgenic mice: Optical imaging. [PDF]

J Cereb Blood Flow Metab
Jeong H, Pan Y, Akhter F, Volkow ND, Zhu D, Du C.   +5 more
europepmc   +1 more source