Results 281 to 290 of about 1,644,173 (317)
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Transgenic RNA Interference in Mice
2008RNA interference (RNAi) is a powerful tool in deciphering gene function. It has been used extensively, especially in cultured mammalian cells. We have shown that RNAi-induced gene silencing can be generated in mice. With conventional transgenic techniques, shRNA-expressing constructs can be introduced into one-cell mouse embryos. The transgenic animals
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Transgenic mice and the pathogenesis of poliomyelitis
1994Transgenic mice expressing the cell receptor for poliovirus have been generated and are susceptible to poliovirus infection. TgPVR mice have been used to answer questions about the pathogenesis of poliovirus infection. Despite the widespread pattern of PVR expression, poliovirus infection in TgPVR mice is restricted to only a few sites, indicating that
R. Ren, Vincent R. Racaniello
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Oncogenesis in Transgenic Mice
1986The study of the diseases collectively labeled cancer has involved a diverse set of approaches, ranging from clinical evaluation and treatment to tumor induction in experimental organisms, and, perhaps most significantly, into the molecular genetics of cell proliferation and growth control. This book is organized around the remarkable body of knowledge
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Postmortem Examination of Transgenic Mice
2003Postmortem examination of transgenic animals should ideally be performed by or with the help of a trained pathologist. This is because although the steps in the examination can be manually performed by anyone, the interpretation of the findings can only be done with the knowledge of veterinary medicine.
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1990
The study of oncogenes and their potential role in human neoplasms represents a fascinating and exponentially growing research area and one which has only in recent years become amenable to molecular biological investigations. This book is organized around the impressive body of knowledge which has accumulated on the molecular biology of growth factors,
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The study of oncogenes and their potential role in human neoplasms represents a fascinating and exponentially growing research area and one which has only in recent years become amenable to molecular biological investigations. This book is organized around the impressive body of knowledge which has accumulated on the molecular biology of growth factors,
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Histological Examination of Transgenic Mice
2003Histological examination is important to detect and differentiate among different types of tissue changes at the microscopic level. An enlarged organ can be hyperplastic, hypertrophied, or neoplastic. It can also be merely inflamed or infected. Only a histological examination can differentiate among the various growth disturbances and pathological ...
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Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1988
Patricia Baldacci +2 more
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Patricia Baldacci +2 more
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The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice
Nature, 2020Linlin Bao, Wei Deng, Hong Gao
exaly