Results 31 to 40 of about 3,709,047 (395)

MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundCardiac stress can trigger production of a 40‐kDa peptide fragment derived from the amino terminus of the cardiac myosin‐binding protein C.
Qinghang Meng, Bidur Bhandary, Hanna Osinska, Jeanne James, Na Xu, Kritton Shay‐Winkler, James Gulick, Monte S. Willis, Cynthia Lander, Jeffrey Robbins   +9 more
doaj   +1 more source

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

Scientific Reports, 2017
Alzheimer’s disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number
T. Harach, N. Marungruang, N. Duthilleul, V. Cheatham, K. D. M. Coy, G. Frisoni, J. Neher, F. Fåk, M. Jucker, T. Lasser, T. Bolmont   +10 more
semanticscholar   +1 more source

Aged wild-type and APP, PS1, and APP+PS1 mice present similar deficits in associative learning and synaptic plasticity independent of amyloid load

Neurobiology of Disease, 2008
Wild-type and single-transgenic (APP, PS1) and double-transgenic (APP+PS1) mice were studied at three different (3-, 12-, and 18-month-old) age periods.
A. Gruart, J.C. López-Ramos, M.D. Muñoz, J.M. Delgado-García   +3 more
doaj   +1 more source

Generation of Fad2 and Fad3 transgenic mice that produce n-6 and n-3 polyunsaturated fatty acids [PDF]

Open Biology, 2019
Linoleic acid (18 : 2, n-6) and α-linolenic acid (18 : 3, n-3) are polyunsaturated fatty acids (PUFAs), which are essential for mammalian health, development and growth.
Lishuang Song, Lei Yang, Jiapeng Wang, Xuefei Liu, Lige Bai, Anqi Di, Guangpeng Li   +6 more
doaj   +1 more source

Functionalization and Characterization of Magnetic Nanoparticles for the Detection of Ferritin Accumulation in Alzheimer's Disease [PDF]

, 2018
Early diagnosis in Alzheimer's disease (AD), prior to the appearance of marked clinical symptoms, is critical to prevent irreversible neuronal damage and neural malfunction that lead to dementia and death.
Cussó, Lorena, Desco, Manuel, Fernández Cabada, Tamara, Martínez Serrano, Alberto, Ramos Gómez, Milagros   +4 more
core   +1 more source

Galanin overexpressing transgenic mice [PDF]

Neuropeptides, 2002
Galanin overexpressing transgenic mice (GAL-tg) were generated on two different promoters. Both lines of GAL-tg displayed high levels of galanin in the hippocampus and reduced sensitivity to seizures, as compared to their respective wildtype littermate controls (WT).
Bartfai, Tamas, Hohmann, John G., Steiner, Robert A., Xu, Zhi-Qing D., Xu, Xiao-Jun, Holmberg, Kristina, Blakeman, Karin H., Hokfelt, Tomas, Mufson, Elliott J., Crawley, Jacqueline N., Wiesenfeld-Hallin, Zsuzsanna, Teklemichael, Dawit N.   +11 more
openaire   +2 more sources

High-Level Neuronal Expression of Aβ1–42 in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Journal of Neuroscience, 2000
Amyloid plaques are a neuropathological hallmark of Alzheimer's disease (AD), but their relationship to neurodegeneration and dementia remains controversial.
L. Mucke, E. Masliah, Gui-qiu Yu, M. Mallory, E. Rockenstein, G. Tatsuno, K. Hu, D. Kholodenko, K. Johnson-wood, L. McConlogue   +9 more
semanticscholar   +1 more source

Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor. [PDF]

PLoS ONE, 2010
Soluble leptin receptor (OBRe), one of several leptin receptor isoforms, is the only bona fide leptin binding protein in plasma. Our earlier studies demonstrated that OBRe modulates leptin levels in circulation.
Phing-How Lou, Guoqing Yang, Lu Huang, Yunxia Cui, Tiffany Pourbahrami, George K Radda, Cai Li, Weiping Han   +7 more
doaj   +1 more source

Functional Genomics for the Identification of Modulators of Platelet-Dependent Thrombus Formation

TH Open, 2018
Despite the absence of the genome in platelets, transcription profiling provides important insights into platelet function and can help clarify abnormalities in platelet disorders.
Elien Vermeersch, Benedicte P. Nuyttens, Claudia Tersteeg, Katleen Broos, Simon F. De Meyer, Karen Vanhoorelbeke, Hans Deckmyn   +6 more
doaj   +1 more source

Factors Affecting Production Efficiency of Bacterial Artificial Chromosome Transgenic Mice

Shiyan dongwu yu bijiao yixue, 2021
ObjectiveBy comparing some key factors in generating bacterial artificial chromosome (BAC) transgenic mice, such as the background of strains, the concentration of the BAC DNA used for injection, the size of the BAC DNA, and the storage time of the BAC ...
WANG Qianqian, WANG Wei, LIU Rui, WEI Zhen, LIU Chong   +4 more
doaj   +1 more source