Results 181 to 190 of about 1,842,059 (303)

Refined Transgenic Mouse Models Which Recapitulate the Natural Features of Chronic Wasting Disease With Rapid Prion Disease Onsets. [PDF]

J Infect Dis
DeFranco JP, Kim S, Atkinson ZN, Crowell J, Lei S, Bian J, Telling GC.   +6 more
europepmc   +1 more source

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

A transgenic mouse model for reticulated platelet detection reveals expansion after myocardial ischemia/reperfusion. [PDF]

Blood Vessel Thromb Hemost
Hamad MA, Schanze N, Krauel K, Lother A, Perez-Feliz S, Iaconianni P, Zurek M, Almushkab L, Madl J, Hollenhorst MA, Kohl P, Nührenberg TG, Duerschmied D.   +12 more
europepmc   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source

Immunomodulation of behavior impairment via spleen-specific targeting lipid nanoparticles in a MeCP2 transgenic mouse model. [PDF]

Sci Rep
Zhang S, Li Y, Yang B, Teymur A, Atrooz F, Majd S, Mohan C, Salim S, Wu T.   +8 more
europepmc   +1 more source

Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models

Advanced Science, EarlyView.
Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka, Yuhei Higashi, Suguru Saito, Solmaz Pourgonabadi, Honami Honjoh, Sho Ishigaki, Peter C. Harris, Lisa M. Satlin, Michifumi Yamashita, Ryuji Morizane   +9 more
wiley   +1 more source

Transgenic mouse models of sodium and potassium channelopathies in epilepsy: insights into disease mechanisms and therapeutics. [PDF]

Biosci Rep
Hammer MF.
europepmc   +1 more source

Molecularly Engineered Phenoxazinone‐Skeleton Cascade‐Activated NIR Probes for Monitoring Fe2+/Viscosity in Ferroptosis‐Mediated Parkinson's Disease

Advanced Science, EarlyView.
A series of Fe2+/viscosity cascade‐activated NIR fluorescence probes (NP1–5) are synthesized, and NP3 is selected for its optimal properties. To verify application of NP3 in ferroptosis intervention in PD, PQR NPs, is constructed by NP3 and quercetin self‐assembling.
Lixia Guo, Tao Liu, Hongfei Wang, Qi Gao, Zhaobo Yang, Zumeng Wang, Chenlong Li, Yubing Kang, Kahleong Lim, Wen Liu, Li Lu, Chengwu Zhang   +11 more
wiley   +1 more source

<i>In vivo</i> 3D imaging of ovarian cancer outgrowth in transgenic mouse model with optical coherence tomography. [PDF]

J Biomed Opt
Han H, Mukhamedjanova A, Connolly DC, Iwanicki MP, Wang S.   +4 more
europepmc   +1 more source

Deep Volumetric Super‐Resolution Imaging in Thick Biological Specimens With Sparse Scanning SIM

Advanced Science, EarlyView.
Sparse scanning structured illumination microscopy (SS‐SIM) extends the axial depth in super‐resolution fluorescence imaging by combining rapid laser scanning, pixel‐addressed intensity modulation, and sCMOS camera detection. SS‐SIM yields 1.6× lateral and 1.7× axial resolution gains over wide‐field microscopy and enables imaging through 300–600 µm ...
Sha An, Xuhong Guo, Zhongxia Cai, Yunze Lei, Kai Wen, Hongfei Suo, Xiaoyu Kong, Gerd Ulrich Nienhaus, Peng Gao   +8 more
wiley   +1 more source