Results 191 to 200 of about 2,621,599 (302)

A comprehensive evaluation of the human Tg32 and Tg276 FcRn transgenic mouse and non-human primate models for predicting antibody pharmacokinetics in human. [PDF]

MAbs
Gajewska M, Kiffe M, Calonder C, Engelhardt V, Pou I Miralbell C, Gonzalo-Gil E, Christianson G, Bethur N, Flora A.   +8 more
europepmc   +1 more source

Transgenic Mouse Bioassay

Interspecies transmission of prions is a well-established phenomenon, both experimentally and under field conditions. Upon passage through new hosts, prion strains have proven their capacity to change their properties and this is a source of strain diversity which needs to be considered when assessing the potential risks associated with consumption of ...
Vidal Barba, Enric||, Fernández-Borges, Natalia, Pintado, Belén, Eraña, Hasier||, Ordóñez, Montserrat, Márquez, Mercedes, Chianini, Francesca, Fondevila, Dolors||, Sánchez-Martín, Manuel A., Andreoletti, Olivier, Dagleish, Mark P., Pumarola i Batlle, Martí||, Castilla, Joaquín||   +12 more
openaire   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

AstroGreen transgenic mouse illuminates the trafficking of astrocyte-derived extracellular vesicles. [PDF]

Mol Cell Neurosci
Nieland L, Haidar EA, Rufino-Ramos D, Prabhakar S, Samaha Y, Breyne K, Fordjour FK, Das S, Broekman MLD, Gould S, Breakefield XO, Abels ER.   +11 more
europepmc   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Retraction Note: Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy. [PDF]

Acta Neuropathol Commun
Valera E, Spencer B, Fields JA, Trinh I, Adame A, Mante M, Rockenstein E, Desplats P, Masliah E.   +8 more
europepmc   +1 more source

Guidelines for High‐Throughput Screening for Natural Products With Anti‐Aging Activity Based on Drosophila Intestinal Homeostasis

AgriFood: Journal of Agricultural Products for Food, EarlyView.
ABSTRACT Aging represents a critical risk factor for chronic diseases, driving an urgent demand for interventions promoting healthy longevity. This study establishes standardized guidelines for high‐throughput screening (HTS) of anti‐aging natural products using Drosophila melanogaster, leveraging its intestinal homeostasis as a biomarker.
Xiao Sheng, Lei Zhang
wiley   +1 more source

Olfactory sensory map is perturbed in a human wild-type α-synuclein overexpressing transgenic mouse model of Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Biju KC, Hernandez ET, Stallings AM, Felix-Ortiz AC, Hebbale SK, Clark RA.   +5 more
europepmc   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

High Blood Levels of Cyclophilin A Increased Susceptibility to Ulcerative Colitis in a Transgenic Mouse Model. [PDF]

Int J Mol Sci
Baikova IP, Ilchuk LA, Kubekina MV, Kalinina AA, Khromykh LM, Okulova YD, Pavlenko NG, Korshunova DS, Korshunov EN, Bruter AV, Silaeva YY.   +10 more
europepmc   +1 more source