Results 181 to 190 of about 1,680,519 (313)
Advanced Science, EarlyView.This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang +10 more
wiley +1 more source
, 2009 Purpose: The transgenic adenocarcinoma of mouse prostate ( TRAMP) model, in which various grades of prostate intraepithelial neoplasia (PIN) and prostate cancer with metastases can be reproducibly generated, is a paradigm for prostate disease progression.
PU, YEONG-SHIAU; LUO, WEIPING; LU, HSIO-HUEI; GREENBERG, NORMAN M.; LIN, SUE-HWA +1 more
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In vivo Assessment of the Potential Protective Effects of Traditional Kumis Against SARS-CoV-2 in a Transgenic Mouse Model. [PDF]
Food Environ VirolKocaman B +7 more
europepmc +1 more source
NLSS3 Impairs SHM1 Autophagic Degradation to Regulate Leaf Morphology and Salt Tolerance in Rice
Advanced Science, EarlyView.In rice, NLSS3 binds and shields SHM1 from autophagic degradation to maintain serine homeostasis. The A132P mutation in nlss3 disrupts this, triggering SHM1 loss, metabolic dysfunction, K+ imbalance, and impaired ROS scavenging, which collectively drive narrow leaves and salt sensitivity.
Xiong Liu +15 more
wiley +1 more source
Advanced Science, EarlyView.This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng +10 more
wiley +1 more source
Editorial Expression of Concern: Increased NK cell immunity in a transgenic mouse model of NKp46 overexpression. [PDF]
Sci RepGlasner A +8 more
europepmc +1 more source
Advanced Science, EarlyView.PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin +11 more
wiley +1 more source
A comprehensive evaluation of the human Tg32 and Tg276 FcRn transgenic mouse and non-human primate models for predicting antibody pharmacokinetics in human. [PDF]
MAbsGajewska M +8 more
europepmc +1 more source
Renal IGFBP6 Interacts With THBS1 to Drive Renal Cellular Senescence and Fibrosis
Advanced Science, EarlyView.ABSTRACT Epithelial dedifferentiation and myofibroblast activation are critical drivers of chronic kidney disease (CKD) progression. Elevated levels of IGFBP6 have been linked to decreased renal function in CKD patients, but its precise role and underlying mechanisms remain unclear.
Ju‐tao Yu +26 more
wiley +1 more source
Efficacy of an Fc-silent antibody targeting the apical domain of human transferrin receptor 1 in transgenic mouse models of Junín virus infection. [PDF]
Antiviral ResLi M +7 more
europepmc +1 more source