Results 11 to 20 of about 1,842,059 (303)

Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease

Disease Models & Mechanisms, 2021
People of recent sub-Saharan African ancestry develop kidney failure much more frequently than other groups. A large fraction of this disparity is due to two coding sequence variants in the APOL1 gene.
Gizelle M. McCarthy, Angelo Blasio, Olivia G. Donovan, Lena B. Schaller, Althea Bock-Hughes, Jose M. Magraner, Jung Hee Suh, Calum F. Tattersfield, Isaac E. Stillman, Shrijal S. Shah, Zsuzsanna K. Zsengeller, Balajikarthick Subramanian, David J. Friedman, Martin R. Pollak   +13 more
doaj   +1 more source

Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS

Communications Biology, 2021
Trabjerg et al. show that the activity of carnitine palmitoyl transferase 1 (CPT1) and lipid metabolism are associated with the disease progression of the SOD1 G93A mouse model mimicking a motor neuron disease Amyotrophic lateral sclerosis (ALS).
Michael Sloth Trabjerg, Dennis Christian Andersen, Pam Huntjens, Kirsten Egelund Oklinski, Luise Bolther, Jonas Laugård Hald, Amalie Elton Baisgaard, Kasper Mørk, Nikolaj Warming, Ulla Bismark Kullab, Lona John Kroese, Colin Eliot Jason Pritchard, Ivo Johan Huijbers, John Dirk Vestergaard Nieland   +13 more
doaj   +1 more source

Identification of the transgene insertion site for an adipocyte-specific adiponectin-cre model and characterization of the functional consequences

Adipocyte, 2021
The Adipoq-Cre transgenic mouse is widely used in the development of adipocyte-specific genetic manipulations for the study of obesity and type 2 diabetes.
Jared S. Farrar, Joseph C. Lownik, Grayson W. Way, Matthew C. Rodriguez, Francesco S. Celi, Rebecca K. Martin   +5 more
doaj   +1 more source

Defective axonal transport in motor neuron disease [PDF]

, 2007
Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas, Blair, Boillee, Bommel, Borchelt, Bowling, Brown, Bruijn, Burger, Cao, Cleveland, Cleveland, Duchen, Escurat, Evans, Fichera, Fliegner, Gaudette, Goldstein, Hadano, Hafezparast, Hazan, Hirokawa, Hirokawa, Hirokawa, Jablonka, Joshi, Kanai, Kaplan, Kieran, King, Kong, LaMonte, Levy, Ligon, Liu, Lo Giudice, Lu, Martin, Miki, Miki, Mitsumoto, Mitsumoto, Muglia, Munch, Nicholson, Nishimura, Okabe, Otomo, Parkinson, Parysek, Pasinelli, Patel, Proukakis, Puls, Puls, Quenneville, Rao, Reid, Reid, Reid, Rosen, Ross, Rowland, Sanderson, Schmitt-John, Shaw, Shibata, Siegel, Song, Teuchert, Troy, Vallee, Weber, Williamson, Wood, Xia, Zhao   +77 more
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A hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome

JHEP Reports, 2021
Background & Aims: Development of new and more effective therapies against hepatitis B virus (HBV) is limited by the lack of suitable small animal models.
Robert L. Kruse, Mercedes Barzi, Xavier Legras, Francis P. Pankowicz, Nika Furey, Lan Liao, Janming Xu, Beatrice Bissig-Choisat, Betty L. Slagle, Karl-Dimiter Bissig   +9 more
doaj   +1 more source

Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice [PDF]

, 2007
The amino acid sequence of amyloid precursor protein (APP) is highly conserved, and age-related Abeta aggregates have been described in a variety of vertebrate animals, with the notable exception of mice and rats.
Borchelt, David R., Fadale, Daniel J., Gonzales, Victoria, Jankowsky, Joanna L., Lester, Henry A., Slunt, Hilda H., Younkin, Linda H., Younkin, Steven G.   +7 more
core   +2 more sources

TT2013 meeting report: the transgenic technology meeting visits Asia for the first time [PDF]

, 2013
The 11th Transgenic Technology meeting was held in Guangzhou, China on 25th–27th February 2013. Over 300 scientists and students from round the world gathered to hear the latest developments in the technologies underpinning the creation of transgenic and
Strathdee, D., Whitelaw, C.B.A.
core   +3 more sources

Trehalose alleviates the phenotype of Machado–Joseph disease mouse models [PDF]

, 2020
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration.
Cavadas, Cláudia, Cunha-Santos, Janete, Gaspar, Laetitia S., Greif, Hagar, Nobre, Rui Jorge, Nóbrega, Clévio, Paixão, Susana, Pereira de Almeida, Luís, Santana, Magda M., Silva, Teresa Pereira, Trevino-Garcia, Allyson   +10 more
core   +1 more source

GPR124 Functions as a WNT7-Specific Coactivator of Canonical β-Catenin Signaling

Cell Reports, 2015
G protein-coupled receptor 124 (GPR124) is an orphan receptor in the adhesion family of GPCRs, and previous global or endothelial-specific disruption of Gpr124 in mice led to defective CNS angiogenesis and blood-brain barriergenesis.
Ekaterina Posokhova, Animesh Shukla, Steven Seaman, Suresh Volate, Mary Beth Hilton, Bofan Wu, Holly Morris, Deborah A. Swing, Ming Zhou, Enrique Zudaire, Jeffrey S. Rubin, Brad St. Croix   +11 more
doaj   +1 more source

A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin. [PDF]

PLoS ONE, 2017
This short technical report describes the generation and characterization of a bioluminescence reporter mouse that is engineered to detect and longitudinally monitor the expression of doxycycline-induced constitutively active β-catenin. The new responder
Maria M Szwarc, Ramakrishna Kommagani, Mary C Peavey, Lan Hai, David M Lonard, John P Lydon   +5 more
doaj   +1 more source