Results 31 to 40 of about 1,680,519 (313)
Enhanced characterization of beta cell mass in a Tg(Pdx1-GFP) mouse model [PDF]
BioImpacts, 2022 Introduction: Measurement of pancreatic beta cell mass in animal models is a common assay in diabetes researches. Novel whole-organ clearance methods in conjunction with transgenic mouse models hold tremendous promise to improve beta cell mass ...
Fatemeh Karami +8 more
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Cerebral amyloid angiopathy : new insights from transgenic mice [PDF]
, 2004 Cerebral amyloid angiopathy (CAA) is characterized by the deposition of congophilic material within the walls of small to medium-sized blood vessels of the brain and leptomeninges.
Herzig, Martin C.
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Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen. [PDF]
, 2012 A large fraction of murine tumors induced by transgenic expression of SV40 large T antigen (SV40 TAg) exhibits a neuroendocrine phenotype. It is unclear whether SV40 TAg induces the neuroendocrine phenotype by preferential transformation of progenitor ...
Georg Enders (187983) +32 more
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Transgenic mouse models for ADHD [PDF]
Cell and Tissue Research, 2013 Attention-deficit hyperactivity disorder (ADHD) is a developmental disorder characterized by symptoms of inattention, impulsivity and hyperactivity that adversely affect many aspects of life. Whereas the etiology of ADHD remains unknown, growing evidence indicates a genetic involvement in the development of this disorder.
Leo, Damiana, Gainetdinov, Raul R.
openaire +2 more sources
Biomedicines, 2022 Colorectal cancer (CRC) is a malignant disease that is the second most common cancer worldwide. CRC arises from the complex interactions among a variety of genetic and environmental factors. To understand the mechanism of colon tumorigenesis, preclinical
Chuangen Li +3 more
doaj +1 more source
A Transgenic Mouse Model for Trilateral Retinoblastoma [PDF]
Archives of Ophthalmology, 1990 We present a murine model of trilateral retinoblastoma. Ocular retinoblastoma and central nervous system tumors are observed in a line of mice formed by the transgenic expression of SV40 T-antigen. An oncogenic protein known to bind to the retinoblastoma gene product (p105-Rb) is specifically expressed within retinal cells in this model.
O'Brien, J.M. +6 more
openaire +3 more sources
9th transgenic technology meeting (TT2010) in Berlin, Germany: a meeting report
, 2010 The first Transgenic Technology (TT) Meeting was organized in 1999 by Johannes Wilbertz, Karolinska Institute, Stockholm, Sweden as a regional meeting.
Saunders, T, Sobieszczuk, Peter
core +1 more source
Transmissibility of caprine scrapie in ovine transgenic mice
BMC Veterinary Research, 2012 Background The United States control program for classical ovine scrapie is based in part on the finding that infection is typically spread through exposure to shed placentas from infected ewes. Transmission from goats to sheep is less well described.
O’Rourke Katherine I +6 more
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A transgenic tri-modality reporter mouse. [PDF]
PLoS ONE, 2013 Transgenic mouse with a stably integrated reporter gene(s) can be a valuable resource for obtaining uniformly labeled stem cells, tissues, and organs for various applications.
Xinrui Yan +7 more
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Murine models of renal disease: Possibilities and problems in studies using mutant mice [PDF]
, 2000 The elucidation of the pathogenesis of human renal disease at the molecular level has been facilitated by the growing field of gene targeting and the development of mouse strains with single-gene deletions - the `knock-out' mice. Experimental nephrology,
Anders, Hans-Joachim +1 more
core +1 more source