Results 21 to 30 of about 1,635,517 (312)
T antigen transgenic mouse models [PDF]
Seminars in Cancer Biology, 2009 The study of polyomavirus has benefited immensely from two scientific methodologies, cell culture and in vitro studies on one side and the use of transgenic mice as experimental models on the other. Both approaches allowed us to identify cellular products targeted by the viruses, the consequences of these interactions at the phenotypic and molecular ...
Maria Teresa, Sáenz Robles +1 more
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Bioluminescence imaging of β cells and intrahepatic insulin gene activity under normal and pathological conditions. [PDF]
PLoS ONE, 2013 In diabetes research, bioluminescence imaging (BLI) has been applied in studies of β-cell impairment, development, and islet transplantation. To develop a mouse model that enables noninvasive imaging of β cells, we generated a bacterial artificial ...
Tokio Katsumata +8 more
doaj +1 more source
Enhanced characterization of beta cell mass in a Tg(Pdx1-GFP) mouse model [PDF]
BioImpacts, 2022 Introduction: Measurement of pancreatic beta cell mass in animal models is a common assay in diabetes researches. Novel whole-organ clearance methods in conjunction with transgenic mouse models hold tremendous promise to improve beta cell mass ...
Fatemeh Karami +8 more
doaj +1 more source
eLife, 2023 Immunoglobulin loci-transgenic animals are widely used in antibody discovery and increasingly in vaccine response modelling. In this study, we phenotypically characterised B-cell populations from the Intelliselect Transgenic mouse (Kymouse) demonstrating
Eve Richardson +11 more
doaj +1 more source
Identification of the Offspring of Vegfr2-luc Transgenic Mouse
Chinese Journal of Lung Cancer, 2011 Background and objective A transgenic mouse, Vegfr2-luc, in which a luciferase reporter (luc) is under control of the murine VEGFR2 promoter, can be used to track angiogenesis in vivo.
Qinghua ZHOU +9 more
doaj +1 more source
Transmissibility of caprine scrapie in ovine transgenic mice
BMC Veterinary Research, 2012 Background The United States control program for classical ovine scrapie is based in part on the finding that infection is typically spread through exposure to shed placentas from infected ewes. Transmission from goats to sheep is less well described.
O’Rourke Katherine I +6 more
doaj +1 more source
Islet Dysfunction in a Novel Transgenic Model of T Cell Insulitis
Biomolecules, 2021 The newly established CD3FLAG-mIR transgenic mouse model on a C57Bl/6 background has a FLAG tag on the mouse Insulin Receptor (mIR), specifically on T cells, as the FLAG-tagged mIR gene was engineered behind CD3 promoter and enhancer.
Emily Esakov +5 more
doaj +1 more source
Disease Models & Mechanisms, 2016 Histone deacetylase 9 (HDAC9) is expressed in B cells, and its overexpression has been observed in B-lymphoproliferative disorders, including B-cell non-Hodgkin lymphoma (B-NHL). We examined HDAC9 protein expression and copy number alterations in primary
Veronica S. Gil +8 more
doaj +1 more source
Enlargement of the Axial Length and Altered Ultrastructural Features of the Sclera in a Mutant Lumican Transgenic Mouse Model. [PDF]
PLoS ONE, 2016 Lumican (LUM) is a candidate gene for myopia in the MYP3 locus. In this study, a mutant lumican (L199P) transgenic mouse model was established to investigate the axial length changes and ultrastructural features of the sclera.
Yanzheng Song +9 more
doaj +1 more source
A transgenic tri-modality reporter mouse. [PDF]
PLoS ONE, 2013 Transgenic mouse with a stably integrated reporter gene(s) can be a valuable resource for obtaining uniformly labeled stem cells, tissues, and organs for various applications.
Xinrui Yan +7 more
doaj +1 more source