Neuropathology in mice expressing mouse alpha-synuclein [PDF]
, 2011 ?-Synuclein (?SN) in human is tightly linked both neuropathologically and genetically to Parkinson's disease (PD) and related disorders. Disease-causing properties in vivo of the wildtype mouse ortholog (m?SN), which carries a threonine at position 53 ...
Kahle, Philipp J. +42 more
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Cerebral amyloidosis in a transgenic mouse model of Alzheimer's disease : impact and therapy [PDF]
, 2003 Senile dementia is a diagnostic category that includes all types of cognitive and memory impairments that occur in the elderly. Alzheimer’s disease (AD) is the most common form of dementia, which is characterized by progressive impairments in memory ...
Boncristiano, Sonia
core +1 more source
Mice expressing RHAG and RHD human blood group genes. [PDF]
PLoS ONE, 2013 Anti-RhD prophylaxis of haemolytic disease of the fetus and newborn (HDFN) is highly effective, but as the suppressive mechanism remains uncertain, a mouse model would be of interest.
Dominique Goossens +7 more
doaj +1 more source
Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor beta-chain [PDF]
, 2010 Introduction: The Vbeta12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)
Burkhardt, H +23 more
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A neuroglobin-overexpressing transgenic mouse [PDF]
Gene, 2007 Neuroglobin (Ngb) is a recently discovered vertebrate globin expressed primarily in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons from these insults. However, its normal physiological role and the mechanism underlying its neuroprotective action are uncertain. We report production of a transgenic mouse in which Ngb
Adil A, Khan +6 more
openaire +2 more sources
Virus-neutralizing monoclonal antibody expressed in milk of transgenic mice provides full protection against virus-induced encephalitis [PDF]
, 2001 Neutralizing antibodies represent a major host defense mechanism against viral infections. In mammals, passive immunity is provided by neutralizing antibodies passed to the offspring via the placenta or the milk as immunoglobulin G and secreted ...
Pewe, L +11 more
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Bioluminescence imaging of β cells and intrahepatic insulin gene activity under normal and pathological conditions. [PDF]
PLoS ONE, 2013 In diabetes research, bioluminescence imaging (BLI) has been applied in studies of β-cell impairment, development, and islet transplantation. To develop a mouse model that enables noninvasive imaging of β cells, we generated a bacterial artificial ...
Tokio Katsumata +8 more
doaj +1 more source
eLife, 2023 Immunoglobulin loci-transgenic animals are widely used in antibody discovery and increasingly in vaccine response modelling. In this study, we phenotypically characterised B-cell populations from the Intelliselect Transgenic mouse (Kymouse) demonstrating
Eve Richardson +11 more
doaj +1 more source
Resting State fMRI Reveals Diminished Functional Connectivity in a Mouse Model of Amyloidosis [PDF]
, 2013 Introduction: Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer’s disease (AD). AD is a complex disorder, characterised by several pathological features. The problem
Rafael Delgado Y Palacios +27 more
core +2 more sources
Identification of the Offspring of Vegfr2-luc Transgenic Mouse
Chinese Journal of Lung Cancer, 2011 Background and objective A transgenic mouse, Vegfr2-luc, in which a luciferase reporter (luc) is under control of the murine VEGFR2 promoter, can be used to track angiogenesis in vivo.
Qinghua ZHOU +9 more
doaj +1 more source