Results 11 to 20 of about 1,680,519 (313)

Identification of the Offspring of Vegfr2-luc Transgenic Mouse

Chinese Journal of Lung Cancer, 2011
Background and objective A transgenic mouse, Vegfr2-luc, in which a luciferase reporter (luc) is under control of the murine VEGFR2 promoter, can be used to track angiogenesis in vivo.
Qinghua ZHOU, Jun CHEN, Min WANG, Yongwen LI, Ying LI, Jing WANG, Yuli WANG, Zhitao SONG, Hongyu LIU, Weiqiang WANG   +9 more
doaj   +2 more sources

Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease

Disease Models & Mechanisms, 2021
People of recent sub-Saharan African ancestry develop kidney failure much more frequently than other groups. A large fraction of this disparity is due to two coding sequence variants in the APOL1 gene.
Gizelle M. McCarthy, Angelo Blasio, Olivia G. Donovan, Lena B. Schaller, Althea Bock-Hughes, Jose M. Magraner, Jung Hee Suh, Calum F. Tattersfield, Isaac E. Stillman, Shrijal S. Shah, Zsuzsanna K. Zsengeller, Balajikarthick Subramanian, David J. Friedman, Martin R. Pollak   +13 more
doaj   +1 more source

Identification of the transgene insertion site for an adipocyte-specific adiponectin-cre model and characterization of the functional consequences

Adipocyte, 2021
The Adipoq-Cre transgenic mouse is widely used in the development of adipocyte-specific genetic manipulations for the study of obesity and type 2 diabetes.
Jared S. Farrar, Joseph C. Lownik, Grayson W. Way, Matthew C. Rodriguez, Francesco S. Celi, Rebecca K. Martin   +5 more
doaj   +1 more source

Cellular, molecular and functional characterisation of YAC transgenic mouse models of Friedreich Ataxia [PDF]

, 2014
Copyright © 2014 Anjomani Virmouni et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author ...
Al-Mahdawi, S, Al-Mahdawi Sahar, Anjomani Virmouni Sara, Virmouni, SA, Sandi, C, Chiranjeevi S, Pook, MA, Sahar Al-Mahdawi, Chiranjeevi Sandi, Sandi Chiranjeevi, Chiranjeevi Sandi (283956), Sara Anjomani Virmouni, Mark A. Pook (126056), Pook Mark A., Mark A. Pook, Sara Anjomani Virmouni (627000), Mark A Pook, Sahar Al-Mahdawi (126054)   +17 more
core   +1 more source

A hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome

JHEP Reports, 2021
Background & Aims: Development of new and more effective therapies against hepatitis B virus (HBV) is limited by the lack of suitable small animal models.
Robert L. Kruse, Mercedes Barzi, Xavier Legras, Francis P. Pankowicz, Nika Furey, Lan Liao, Janming Xu, Beatrice Bissig-Choisat, Betty L. Slagle, Karl-Dimiter Bissig   +9 more
doaj   +1 more source

Experimental approaches to study cerebral amyloidosis in a transgenic mouse model of Alzheimer's disease [PDF]

, 2004
Misfolding, aggregation and the accumulation of proteins in the brain are common characteristics of diverse age-related neurodegenerative diseases. Each of these neurodegenerative diseases is associated with abnormalities in the folding of a different
Meyer-Lühmann, Melanie
core   +1 more source

Neurodegeneration and neurogenesis in mouse models of aging and Alzheimer's disease [PDF]

, 2003
As the proportion of senior citizens gradually increases, the behavioral changes that occur with normal aging and as a consequence of Alzheimer’s disease (AD) will afflict many of us in the future.
Bondolfi, Luca E.
core   +1 more source

Cerebral amyloidosis in a transgenic mouse model of Alzheimer's disease : impact and therapy [PDF]

, 2003
Senile dementia is a diagnostic category that includes all types of cognitive and memory impairments that occur in the elderly. Alzheimer’s disease (AD) is the most common form of dementia, which is characterized by progressive impairments in memory ...
Boncristiano, Sonia
core   +1 more source

GPR124 Functions as a WNT7-Specific Coactivator of Canonical β-Catenin Signaling

Cell Reports, 2015
G protein-coupled receptor 124 (GPR124) is an orphan receptor in the adhesion family of GPCRs, and previous global or endothelial-specific disruption of Gpr124 in mice led to defective CNS angiogenesis and blood-brain barriergenesis.
Ekaterina Posokhova, Animesh Shukla, Steven Seaman, Suresh Volate, Mary Beth Hilton, Bofan Wu, Holly Morris, Deborah A. Swing, Ming Zhou, Enrique Zudaire, Jeffrey S. Rubin, Brad St. Croix   +11 more
doaj   +1 more source

A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin. [PDF]

PLoS ONE, 2017
This short technical report describes the generation and characterization of a bioluminescence reporter mouse that is engineered to detect and longitudinally monitor the expression of doxycycline-induced constitutively active β-catenin. The new responder
Maria M Szwarc, Ramakrishna Kommagani, Mary C Peavey, Lan Hai, David M Lonard, John P Lydon   +5 more
doaj   +1 more source