Results 11 to 20 of about 2,621,599 (302)

Quantitative investigations of FXN transcription and epigenetic modifications, including histone acetylation and methylation, in FRDA human and mouse tissues [PDF]

, 2009
This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder characterized by progressive gait and, limb ataxia, cardiomayopathy ...
Trabzuni, Daniah M
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Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease

Disease Models & Mechanisms, 2021
People of recent sub-Saharan African ancestry develop kidney failure much more frequently than other groups. A large fraction of this disparity is due to two coding sequence variants in the APOL1 gene.
Gizelle M. McCarthy, Angelo Blasio, Olivia G. Donovan, Lena B. Schaller, Althea Bock-Hughes, Jose M. Magraner, Jung Hee Suh, Calum F. Tattersfield, Isaac E. Stillman, Shrijal S. Shah, Zsuzsanna K. Zsengeller, Balajikarthick Subramanian, David J. Friedman, Martin R. Pollak   +13 more
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Identification of the transgene insertion site for an adipocyte-specific adiponectin-cre model and characterization of the functional consequences

Adipocyte, 2021
The Adipoq-Cre transgenic mouse is widely used in the development of adipocyte-specific genetic manipulations for the study of obesity and type 2 diabetes.
Jared S. Farrar, Joseph C. Lownik, Grayson W. Way, Matthew C. Rodriguez, Francesco S. Celi, Rebecca K. Martin   +5 more
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Cellular, molecular and functional characterisation of YAC transgenic mouse models of Friedreich Ataxia [PDF]

, 2014
Copyright © 2014 Anjomani Virmouni et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author ...
Al-Mahdawi, S, Al-Mahdawi Sahar, Anjomani Virmouni Sara, Virmouni, SA, Sandi, C, Chiranjeevi S, Pook, MA, Sahar Al-Mahdawi, Chiranjeevi Sandi, Sandi Chiranjeevi, Chiranjeevi Sandi (283956), Sara Anjomani Virmouni, Mark A. Pook (126056), Pook Mark A., Mark A. Pook, Sara Anjomani Virmouni (627000), Mark A Pook, Sahar Al-Mahdawi (126054)   +17 more
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A hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome

JHEP Reports, 2021
Background & Aims: Development of new and more effective therapies against hepatitis B virus (HBV) is limited by the lack of suitable small animal models.
Robert L. Kruse, Mercedes Barzi, Xavier Legras, Francis P. Pankowicz, Nika Furey, Lan Liao, Janming Xu, Beatrice Bissig-Choisat, Betty L. Slagle, Karl-Dimiter Bissig   +9 more
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Experimental approaches to study cerebral amyloidosis in a transgenic mouse model of Alzheimer's disease [PDF]

, 2004
Misfolding, aggregation and the accumulation of proteins in the brain are common characteristics of diverse age-related neurodegenerative diseases. Each of these neurodegenerative diseases is associated with abnormalities in the folding of a different
Meyer-Lühmann, Melanie
core   +1 more source

Neurodegeneration and neurogenesis in mouse models of aging and Alzheimer's disease [PDF]

, 2003
As the proportion of senior citizens gradually increases, the behavioral changes that occur with normal aging and as a consequence of Alzheimer’s disease (AD) will afflict many of us in the future.
Bondolfi, Luca E.
core   +1 more source

GPR124 Functions as a WNT7-Specific Coactivator of Canonical β-Catenin Signaling

Cell Reports, 2015
G protein-coupled receptor 124 (GPR124) is an orphan receptor in the adhesion family of GPCRs, and previous global or endothelial-specific disruption of Gpr124 in mice led to defective CNS angiogenesis and blood-brain barriergenesis.
Ekaterina Posokhova, Animesh Shukla, Steven Seaman, Suresh Volate, Mary Beth Hilton, Bofan Wu, Holly Morris, Deborah A. Swing, Ming Zhou, Enrique Zudaire, Jeffrey S. Rubin, Brad St. Croix   +11 more
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A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin. [PDF]

PLoS ONE, 2017
This short technical report describes the generation and characterization of a bioluminescence reporter mouse that is engineered to detect and longitudinally monitor the expression of doxycycline-induced constitutively active β-catenin. The new responder
Maria M Szwarc, Ramakrishna Kommagani, Mary C Peavey, Lan Hai, David M Lonard, John P Lydon   +5 more
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Human Zona Pellucida Glycoproteins: Binding Characteristics With Human Spermatozoa and Induction of Acrosome Reaction

Frontiers in Cell and Developmental Biology, 2021
Human zona pellucida (ZP) matrix is composed of four glycoproteins designated as ZP glycoprotein -1 (ZP1), -2 (ZP2), -3 (ZP3), and -4 (ZP4). Mutations in the genes encoding human ZP glycoproteins are one of the causative factors leading to abnormal ZP ...
Satish Kumar Gupta
doaj   +1 more source