Results 11 to 20 of about 1,635,517 (312)
Disease Models & Mechanisms, 2021 People of recent sub-Saharan African ancestry develop kidney failure much more frequently than other groups. A large fraction of this disparity is due to two coding sequence variants in the APOL1 gene.
Gizelle M. McCarthy +13 more
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Adipocyte, 2021 The Adipoq-Cre transgenic mouse is widely used in the development of adipocyte-specific genetic manipulations for the study of obesity and type 2 diabetes.
Jared S. Farrar +5 more
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A hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome
JHEP Reports, 2021 Background & Aims: Development of new and more effective therapies against hepatitis B virus (HBV) is limited by the lack of suitable small animal models.
Robert L. Kruse +9 more
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GPR124 Functions as a WNT7-Specific Coactivator of Canonical β-Catenin Signaling
Cell Reports, 2015 G protein-coupled receptor 124 (GPR124) is an orphan receptor in the adhesion family of GPCRs, and previous global or endothelial-specific disruption of Gpr124 in mice led to defective CNS angiogenesis and blood-brain barriergenesis.
Ekaterina Posokhova +11 more
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A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin. [PDF]
PLoS ONE, 2017 This short technical report describes the generation and characterization of a bioluminescence reporter mouse that is engineered to detect and longitudinally monitor the expression of doxycycline-induced constitutively active β-catenin. The new responder
Maria M Szwarc +5 more
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Frontiers in Cell and Developmental Biology, 2021 Human zona pellucida (ZP) matrix is composed of four glycoproteins designated as ZP glycoprotein -1 (ZP1), -2 (ZP2), -3 (ZP3), and -4 (ZP4). Mutations in the genes encoding human ZP glycoproteins are one of the causative factors leading to abnormal ZP ...
Satish Kumar Gupta
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Transgenic mouse models for ADHD [PDF]
Cell and Tissue Research, 2013 Attention-deficit hyperactivity disorder (ADHD) is a developmental disorder characterized by symptoms of inattention, impulsivity and hyperactivity that adversely affect many aspects of life. Whereas the etiology of ADHD remains unknown, growing evidence indicates a genetic involvement in the development of this disorder.
Leo, Damiana, Gainetdinov, Raul R.
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Mice expressing RHAG and RHD human blood group genes. [PDF]
PLoS ONE, 2013 Anti-RhD prophylaxis of haemolytic disease of the fetus and newborn (HDFN) is highly effective, but as the suppressive mechanism remains uncertain, a mouse model would be of interest.
Dominique Goossens +7 more
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Biomedicines, 2022 Colorectal cancer (CRC) is a malignant disease that is the second most common cancer worldwide. CRC arises from the complex interactions among a variety of genetic and environmental factors. To understand the mechanism of colon tumorigenesis, preclinical
Chuangen Li +3 more
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A neuroglobin-overexpressing transgenic mouse [PDF]
Gene, 2007 Neuroglobin (Ngb) is a recently discovered vertebrate globin expressed primarily in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons from these insults. However, its normal physiological role and the mechanism underlying its neuroprotective action are uncertain. We report production of a transgenic mouse in which Ngb
Adil A, Khan +6 more
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