Results 21 to 30 of about 1,842,059 (303)

Human Zona Pellucida Glycoproteins: Binding Characteristics With Human Spermatozoa and Induction of Acrosome Reaction

Frontiers in Cell and Developmental Biology, 2021
Human zona pellucida (ZP) matrix is composed of four glycoproteins designated as ZP glycoprotein -1 (ZP1), -2 (ZP2), -3 (ZP3), and -4 (ZP4). Mutations in the genes encoding human ZP glycoproteins are one of the causative factors leading to abnormal ZP ...
Satish Kumar Gupta
doaj   +1 more source

Transgenic mouse models for ADHD [PDF]

Cell and Tissue Research, 2013
Attention-deficit hyperactivity disorder (ADHD) is a developmental disorder characterized by symptoms of inattention, impulsivity and hyperactivity that adversely affect many aspects of life. Whereas the etiology of ADHD remains unknown, growing evidence indicates a genetic involvement in the development of this disorder.
Leo, Damiana, Gainetdinov, Raul R.
openaire   +2 more sources

Downregulation of FGF Signaling by Spry4 Overexpression Leads to Shape Impairment, Enamel Irregularities, and Delayed Signaling Center Formation in the Mouse Molar. [PDF]

, 2019
FGF signaling plays a critical role in tooth development, and mutations in modulators of this pathway produce a number of striking phenotypes. However, many aspects of the role of the FGF pathway in regulating the morphological features and the mineral ...
Ahn, Youngwook, Charles, Cyril, Ganss, Bernhard, Jheon, Andrew, Klein, Ophir D, Krumlauf, Robb, Marangoni, Pauline, Seidel, Kerstin, Viriot, Laurent   +8 more
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Mice expressing RHAG and RHD human blood group genes. [PDF]

PLoS ONE, 2013
Anti-RhD prophylaxis of haemolytic disease of the fetus and newborn (HDFN) is highly effective, but as the suppressive mechanism remains uncertain, a mouse model would be of interest.
Dominique Goossens, Nelly da Silva, Sylvain Metral, Ulrich Cortes, Isabelle Callebaut, Julien Picot, Isabelle Mouro-Chanteloup, Jean-Pierre Cartron   +7 more
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Prospects for transgenesis in the chick [PDF]

, 2004
Research to develop a useful method for genetic modification of the chick has been on-going since the first demonstrations in the mouse in the 1980s that genetic modification is an invaluable tool for the study of gene function. Manipulation of the chick
Bosselman, Brazolot, Carsience, Challita, D'Costa, Evans, Eyal-Giladi, Hamburger, Han, Harvey, Harvey, Hofmann, Ikawa, Isvak, Itasaki, Ivarie, Kagami, Lois, Love, Mizuarai, Mozdziak, Mozdziak, Naito, Naito, Naito, Naldini, Nieuwkoop, Niwa, Pain, Perry, Petitte, Petitte, Pfeifer, Rapp, Reynaud, Rubinson, Salter, Salter, Sang, Sherman, Speksnijder, Stern, Tajima, Thomson, Thoraval, Tiscornia, Tsunekawa, Urven, Vick, Vick, Waddington, Wentworth, Zajchowski   +52 more
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A neuroglobin-overexpressing transgenic mouse [PDF]

Gene, 2007
Neuroglobin (Ngb) is a recently discovered vertebrate globin expressed primarily in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons from these insults. However, its normal physiological role and the mechanism underlying its neuroprotective action are uncertain. We report production of a transgenic mouse in which Ngb
Adil A, Khan, Yunjuan, Sun, Kunlin, Jin, Xiao Ou, Mao, Sylvia, Chen, Lisa M, Ellerby, David A, Greenberg   +6 more
openaire   +2 more sources

Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. [PDF]

, 2013
NG2 (nerve/glial antigen2)-expressing cells represent the largest population of postnatal progenitors in the central nervous system and have been classified as oligodendroglial progenitor cells, but the fate and function of these cells remain ...
Chung, S-H, Deng, W, Guo, F, Jiang, P, Pleasure, DE   +4 more
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T antigen transgenic mouse models [PDF]

Seminars in Cancer Biology, 2009
The study of polyomavirus has benefited immensely from two scientific methodologies, cell culture and in vitro studies on one side and the use of transgenic mice as experimental models on the other. Both approaches allowed us to identify cellular products targeted by the viruses, the consequences of these interactions at the phenotypic and molecular ...
Maria Teresa, Sáenz Robles, James M, Pipas   +1 more
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Bioluminescence imaging of β cells and intrahepatic insulin gene activity under normal and pathological conditions. [PDF]

PLoS ONE, 2013
In diabetes research, bioluminescence imaging (BLI) has been applied in studies of β-cell impairment, development, and islet transplantation. To develop a mouse model that enables noninvasive imaging of β cells, we generated a bacterial artificial ...
Tokio Katsumata, Hisashi Oishi, Yukari Sekiguchi, Haruka Nagasaki, Dhouha Daassi, Pei-Han Tai, Masatsugu Ema, Takashi Kudo, Satoru Takahashi   +8 more
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Enhanced characterization of beta cell mass in a Tg(Pdx1-GFP) mouse model [PDF]

BioImpacts, 2022
Introduction: Measurement of pancreatic beta cell mass in animal models is a common assay in diabetes researches. Novel whole-organ clearance methods in conjunction with transgenic mouse models hold tremendous promise to improve beta cell mass ...
Fatemeh Karami, Behrouz Asgari Abibeiglou, Saghar Pahlavanneshan, Ali Farrokhi, Amin Tamadon, Mohsen Basiri, Keynoosh Khalooghi, Majid Fallahi, Yaser Tahamtani   +8 more
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