Results 31 to 40 of about 1,842,059 (303)

Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencing

eLife, 2023
Immunoglobulin loci-transgenic animals are widely used in antibody discovery and increasingly in vaccine response modelling. In this study, we phenotypically characterised B-cell populations from the Intelliselect Transgenic mouse (Kymouse) demonstrating
Eve Richardson, Špela Binter, Miha Kosmac, Marie Ghraichy, Valentin von Niederhäusern, Aleksandr Kovaltsuk, Jacob D Galson, Johannes Trück, Dominic F Kelly, Charlotte M Deane, Paul Kellam, Simon J Watson   +11 more
doaj   +1 more source

Mouse Models for Application in Colorectal Cancer: Understanding the Pathogenesis and Relevance to the Human Condition

Biomedicines, 2022
Colorectal cancer (CRC) is a malignant disease that is the second most common cancer worldwide. CRC arises from the complex interactions among a variety of genetic and environmental factors. To understand the mechanism of colon tumorigenesis, preclinical
Chuangen Li, Harry Cheuk-Hay Lau, Xiang Zhang, Jun Yu   +3 more
doaj   +1 more source

Aberrant Polycystin-1 Expression Results in Modification of Activator Protein-1 Activity, whereas Wnt Signaling Remains Unaffected [PDF]

, 2004
Polycystin-1, the polycystic kidney disease 1 gene product, has been implicated in several signaling complexes that are known to regulate essential cellular functions. We investigated the role of polycystin-1 in Wnt signaling and activator protein-1 (
Arnould, Bhunia, Duyndam, Giles, Grotewold, Huan, Kim, Kimberling, Kugoh, Loghman-Adham, Löhning, Morin, Moser, Muto, Newby, Ouwens, Parnell, Peters, Pritchard, Rivat, Rodova, Saadi-Kheddouci, Scheffers, Shaulian, Smits, Sorenson, Spaargaren, Streets, Sutters, Trudel, Upadhya, van Adelsberg, van Dam, van Dam, van Dam, van Dam, van de Wetering, van de Wetering   +37 more
core   +3 more sources

Identification of the Offspring of Vegfr2-luc Transgenic Mouse

Chinese Journal of Lung Cancer, 2011
Background and objective A transgenic mouse, Vegfr2-luc, in which a luciferase reporter (luc) is under control of the murine VEGFR2 promoter, can be used to track angiogenesis in vivo.
Qinghua ZHOU, Jun CHEN, Min WANG, Yongwen LI, Ying LI, Jing WANG, Yuli WANG, Zhitao SONG, Hongyu LIU, Weiqiang WANG   +9 more
doaj   +1 more source

A transgenic tri-modality reporter mouse. [PDF]

PLoS ONE, 2013
Transgenic mouse with a stably integrated reporter gene(s) can be a valuable resource for obtaining uniformly labeled stem cells, tissues, and organs for various applications.
Xinrui Yan, Pritha Ray, Ramasamy Paulmurugan, Ricky Tong, Yongquan Gong, Ataya Sathirachinda, Joseph C Wu, Sanjiv S Gambhir   +7 more
doaj   +1 more source

Transmissibility of caprine scrapie in ovine transgenic mice

BMC Veterinary Research, 2012
Background The United States control program for classical ovine scrapie is based in part on the finding that infection is typically spread through exposure to shed placentas from infected ewes. Transmission from goats to sheep is less well described.
O’Rourke Katherine I, Schneider David A, Spraker Terry R, Dassanayake Rohana P, Highland Margaret A, Zhuang Dongyue, Truscott Thomas C   +6 more
doaj   +1 more source

Islet Dysfunction in a Novel Transgenic Model of T Cell Insulitis

Biomolecules, 2021
The newly established CD3FLAG-mIR transgenic mouse model on a C57Bl/6 background has a FLAG tag on the mouse Insulin Receptor (mIR), specifically on T cells, as the FLAG-tagged mIR gene was engineered behind CD3 promoter and enhancer.
Emily Esakov, Neha Nandedkar-Kulkarni, Ali G. Al-Dieri, Hannah Hafner, Brigid Gregg, Marcia F. McInerney   +5 more
doaj   +1 more source

Measuring neuromuscular junction functionality [PDF]

, 2017
Neuromuscular junction (NMJ) functionality plays a pivotal role when studying diseases in which the communication between motor neuron and muscle is impaired, such as aging and amyotrophic lateral sclerosis (ALS).
Del Prete, Zaccaria, Musaro, Antonio, Nicoletti, Carmine, Pisu, Simona, Rizzuto, Emanuele   +4 more
core   +1 more source

Deregulated expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma in mice

Disease Models & Mechanisms, 2016
Histone deacetylase 9 (HDAC9) is expressed in B cells, and its overexpression has been observed in B-lymphoproliferative disorders, including B-cell non-Hodgkin lymphoma (B-NHL). We examined HDAC9 protein expression and copy number alterations in primary
Veronica S. Gil, Govind Bhagat, Louise Howell, Jiyuan Zhang, Chae H. Kim, Sven Stengel, Francisco Vega, Arthur Zelent, Kevin Petrie   +8 more
doaj   +1 more source

Systems Biology Analysis of the Antagonizing Effects of HIV-1 Tat Expression in the Brain over Transcriptional Changes Caused by Methamphetamine Sensitization

Viruses, 2020
Methamphetamine (Meth) abuse is common among humans with immunodeficiency virus (HIV). The HIV-1 regulatory protein, trans-activator of transcription (Tat), has been described to induce changes in brain gene transcription that can result in impaired ...
Liana V. Basova, James P. Kesby, Marcus Kaul, Svetlana Semenova, Maria Cecilia Garibaldi Marcondes   +4 more
doaj   +1 more source