Results 41 to 50 of about 1,842,059 (303)

Enlargement of the Axial Length and Altered Ultrastructural Features of the Sclera in a Mutant Lumican Transgenic Mouse Model. [PDF]

PLoS ONE, 2016
Lumican (LUM) is a candidate gene for myopia in the MYP3 locus. In this study, a mutant lumican (L199P) transgenic mouse model was established to investigate the axial length changes and ultrastructural features of the sclera.
Yanzheng Song, Fengju Zhang, Yanyan Zhao, Mingshen Sun, Jun Tao, Yanchuang Liang, Ling Ma, Yanqiu Yu, Jianhua Wang, Junfeng Hao   +9 more
doaj   +1 more source

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning [PDF]

, 2007
Sonic hedgehog (Shh) acts as a morphogen to mediate the specification of distinct cell identities in the ventral neural tube through a Gli-mediated (Gli1-3) transcriptional network.
Davidson, Eric H., Giles, Shane, Ji, Hongkai, Longabaugh, William J. R., McCuine, Scott, McMahon, Andrew P., Tenzen, Toyoaki, Vokes, Steven A., Wong, Wing H., Zhong, Sheng   +9 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology

Molecular Neurodegeneration
Background Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD). A recent case report identified a rare variant in APOE, APOE3-R136S (Christchurch), proposed to confer resistance to autosomal dominant
Kristine M. Tran, Nellie E. Kwang, Claire A. Butler, Angela Gomez-Arboledas, Shimako Kawauchi, Cassandra Mar, Donna Chao, Rocio A. Barahona, Celia Da Cunha, Kate I. Tsourmas, Zechuan Shi, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Joshua A. Alcantara, Jonathan Neumann, Duc M. Duong, Nicholas T. Seyfried, Andrea J. Tenner, Frank M. LaFerla, Lindsay A. Hohsfield, Vivek Swarup, Grant R. MacGregor, Kim N. Green   +24 more
doaj   +1 more source

Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength [PDF]

, 2015
Patients with acromegaly have a higher prevalence of vertebral fractures despite normal bone mineral density (BMD), suggesting that GH overexpression has adverse effects on skeletal architecture and strength. We used giant bovine GH (bGH) transgenic mice
Chavassieux, P, Chenu, C, Hopkinson, M, Javaheri, B, Kopchick, J, Korbonits, M, Lim, SV, List, E, Marenzana, M, Pereira, M, Roux, J   +10 more
core   +4 more sources

Transgenic Mouse Models of Alzheimer's Disease [PDF]

Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine, 2010
AbstractAlzheimer's disease is the most common cause of senile dementia in the United States and Europe. At present, there is no effective treatment. Given the disease's prevalence and poor prognosis, the development of animal models has been a high research priority.
Gregory A, Elder, Miguel A, Gama Sosa, Rita, De Gasperi   +2 more
openaire   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

An Efficient Method for Generation of Transgenic Rats Avoiding Embryo Manipulation

Molecular Therapy: Nucleic Acids, 2016
Although rats are preferred over mice as an animal model, transgenic animals are generated predominantly using mouse embryos. There are limitations in the generation of transgenic rat by embryo manipulation.
Bhola Shankar Pradhan, Subeer S. Majumdar   +1 more
doaj   +1 more source

Aldh1a1 and additional markers of dopamine cell heterogeneity in substantia nigra and ventral tegmental area identified as preserved in two transgenic α-synuclein mouse models of neurodegenerative disease

Exploration of Neuroprotective Therapy, 2023
Aim: Parkinson’s disease (PD) is characterized by degeneration of midbrain dopamine neurons and synucleinopathy [aggregated alpha-synuclein protein (αSyn)].
Bianca Vlcek, Sylvie Dumas, Sara Ekmark-Lewén, Eleonora Rubino, Martin Ingelsson, Åsa Wallén-Mackenzie   +5 more
doaj   +1 more source

Functionalization and Characterization of Magnetic Nanoparticles for the Detection of Ferritin Accumulation in Alzheimer's Disease [PDF]

, 2018
Early diagnosis in Alzheimer's disease (AD), prior to the appearance of marked clinical symptoms, is critical to prevent irreversible neuronal damage and neural malfunction that lead to dementia and death.
Cussó, Lorena, Desco, Manuel, Fernández Cabada, Tamara, Martínez Serrano, Alberto, Ramos Gómez, Milagros   +4 more
core   +1 more source