Results 71 to 80 of about 159,058 (244)
Tobacco transcription factor WRKY4 is a modulator of leaf development and disease resistance
Biologia Plantarum, 2010 The role of tobacco transcription factor WRKY4 in leaf development and biotic stress tolerance was studied using RNAi suppressed transgenic plants. The leaves were more numerous and wider in NtWRKY4 RNAi suppressed transgenic lines compared to the vector
X.-J. Ren +3 more
doaj +1 more source
Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva +28 more
wiley +1 more source
Advanced Science, EarlyView.This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang +15 more
wiley +1 more source
EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer
Advanced Science, EarlyView.This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv +8 more
wiley +1 more source
Increased glutathione S-transferase activity in 35S(CaMV)-Zmgstf4 transgenic Arabidopsis thaliana
Ecocycles, 2017 Clones of 35S-Zmgstf4 transgenic Arabidopsis thaliana expressing the glutathione S-transferase F4 gene of Zea mays, were tested for stress-inductive GST (glutathione S-transferase) activity following treatments with the heavy metals Zn (150 and 1500 μM),
Andras Bittsanszky, Gabor Gyulai
doaj +1 more source
High plant density increases seed Bt endotoxin content in Bt transgenic cotton
, 2021 Yuan Chen +4 more
openalex +1 more source
Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Advanced Science, EarlyView.Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen +4 more
wiley +1 more source
Molecular Plant-Microbe Interactions, 2003 Plant disease resistance (R) gene products recognize pathogen avirulence (Avr) gene products and induce defense responses. It is not known if an R gene can function in different plant families, however.
Shunyuan Xiao +3 more
doaj +1 more source
Advanced Science, EarlyView.A carbon nanotube‐based biopesticide system (BioCNTs) enables efficient delivery and systemic movement of RNAi molecules to control major tomato viruses. By integrating shRNA and tRNA‐like structures (TLS) with BioCNTs, this green and scalable approach achieves long‐term silencing and high antiviral efficacy through simple foliar spraying.
Xuedong Liu +7 more
wiley +1 more source
Callose deposition at plasmodesmata suggests a role in viral movement restriction in transgenic tobacco plants during recovery from Tobacco etch virus infection [PDF]
, 2022 Pablo Vargas-Mejía +6 more
openalex +1 more source