Results 31 to 40 of about 3,961,294 (191)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Gene up-regulation by DNA demethylation in 35S-gshI-transgenic poplars (Populus x canescens) [PDF]

, 2008
Gene expression levels of transgene 35S-gshI (γ-glutamylcysteine synthetase) cloned from E. coli, and the endogenous gene gsh1 of poplar (Populus x canescens) were upregulated by the DNA demethylating agent DHAC (5,6-dihydro-5'-azacytidine ...
Gyulai, Gábor, Heszky, László, Szabó, Zoltán, Tóth, Z., Bittsánszky, András, Kiss, J., Gullner, Gábor, Kőmíves, Tamás   +7 more
core   +1 more source

Increased mutagenicity in the liver of MutaMouse females following oral treatment with commercial-grade toluene diisocyanate

Genes and Environment
Background Toluene diisocyanates (TDIs) are high-production-volume chemicals widely used in polyurethane manufacturing. A typical commercial-grade TDI (TDI; 2,4-toluene diisocyanate: 2,6-toluene diisocyanate; 80:20), CAS: 26471-62-5, is mutagenic in ...
Mariko Matsumoto, Masakatsu Natsume, Takako Iso, Takaaki Umano, Yasumasa Murata, Kenichi Masumura, Katsuyoshi Horibata, Kei-ichi Sugiyama   +7 more
doaj   +1 more source

Reference materials (RMs) for analysis of the human factor II (prothrombin) gene G20210A mutation [PDF]

, 2005
The Scientific Committee of Molecular Biology Techniques (C-MbT) in Clinical Chemistry of the IFCC has initiated a joint project in co-operation with the European Commission, Joint Research Centre, Institute of Reference Materials and Measurements to ...
Tosetto, Alberto, Visvikis, Sophie, RIEGER Sandra, GANCBERG D, Kitchen, Steve, MARKI-ZAY Janos, MANNHALTER C., Schimmel, Heinz G., VISVIKIS S, Gancberg, David, CORBISIER P, REITSMA Pieter, KITCHEN S, TORDAI A, Rieger, Sandra, Halbmayer, Walter-Michael, REITSMA PH, SPANNAGL M, GANCBERG David, Tordai, Attilia, Opplinger Leibundgut, Elisabeth, SPANNAGL Michael, OPPLIGER LEIBUNDGUT E, NEUMAIER Michael, Oppliger Leibundgut, Elisabeth, MELEGH B, CORBISIER Philippe, OLDENBURG Johannes, RIEGER S, Corbisier, Philippe, OLDENBURG J, COOPER S, HALBMAYER Walter-Michael, Cooper, Susan, HALBMAYER WM, COOPER Susan, KITCHEN Steve, MRKI ZAY J, Reitsma, Pieter H., Marki-Zay, János, Gemmati, Donato, TOSETTO A, VISVIKIS Sophie, TORDAI Attila, Melegh, Béla, Zadro, Renata, SCHIMMEL HG, Neumaier, Michael, KLEIN Christoph, SCHIMMEL Heinz, TOSETTO Alberto, Oldenburg, Johannes, MANNHALTER Christine, ZADRO R, Mannhalter, Christine, Klein, Christoph L., MELEGH Bela, NEUMAIER M, Spannagl, Michael, KLEIN CL, OPPLIGER LEIBUNDGUT Elisabeth, Cooper, S., GEMMATI Donato, ZADRO Renata   +63 more
core   +2 more sources

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus [PDF]

, 1996
The myosin light-chain 1/3 locus (MLC1/3) is regulated by two promoters and a downstream enhancer element which produce two protein isoforms in fast skeletal muscle at distinct stages of mouse embryogenesis. We have analyzed the expression of transcripts
McGrew, M J; id_orcid, Hasegawa, K, Bogdanova, N, Kitsis, R N, Rosenthal, N, Hughes, S H   +5 more
core  

Test No. 480: Genetic Toxicology: Saccharomyces cerevisiae, Gene Mutation Assay [electronic resource] /

, 1986
Following the OECD Council decision, the Test Guideline 480 ‘Genetic Toxicology: Saccharomyces cerevisiae, Gene Mutation Assay’ was deleted on 2nd April 2014.Following the OECD Council decision, the Test Guideline 480 ‘Genetic Toxicology: Saccharomyces ...
Organisation for Economic Co-operation and Development., null null   +1 more
core   +1 more source

A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals [PDF]

, 2019
A database of 91 chemicals with published data from both transgenic rodent mutation (TGR) and rodent comet assays has been compiled. The objective was to compare the sensitivity of the two assays for detecting genotoxicity.
Bhalli, J, Stankowski, Leon F, Aardema, MJ, Roberts, DJ, Thybaud, V, Kulkarni, R, Witt, KL, Guerard, Melanie, Johnson, GE, Williams, Andrew, Weiner, Sandy K, Douglas, George R, Thybaud, Veronique, Levy, Dan D, Pfuhler, S, Lovell, David P, Le Curieux, F, Weiner, SK, Stankowski, LF, Nicolette, John J, Escobar, PA, LeBaron, MJ, Williams, A, Beevers, C, Long, Alexandra S, Lott, J, Pfuhler, Stefan, Escobar, Patricia A, Farabaugh, Christopher S, Luijten, Mirjam, Farabaugh, CS, Beevers, Carol, George Johnson, Roberts, Daniel J, Lott, Jasmin, Marchetti, Francesco, Levy, DD, Johnson, George E, Guerard, M, Luijten, M, Long, AS, Kirkland, David, Bhalli, Javed, Young, R, Douglas, GR, Aardema, Marilyn J, Nicolette, JJ, Young, Robert, LeBaron, Matthew J, Le Curieux, Frank, Witt, Kristine L, Kirkland, D, Lovell, DP, Marchetti, F, Kulkarni, Rohan   +54 more
core   +1 more source

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

A Genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology [PDF]

, 2015
We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene).
Cummings, DM, Moens, TG, Fulleylove, M, Liu, W, Latcham, J, Smith, KJ, NahabooSolim, MA, Edwards, FA, Desai, R, Ali, SS, Matarin, M, Paublete, RM, Perona, M, Salih, DA, Guelfi, S, Richardson, JC, Yasvoina, M, Hardy, J   +17 more
core