Results 51 to 60 of about 3,961,294 (191)

Goofy/123Cre lineage tracing differentiates olfactory and vomeronasal neurons from GnRH‐1 and terminal nerve neurons during neuronal migration and reveals additional olfactory placode‐derived cells in the brain

Developmental Dynamics, EarlyView.
Abstract The olfactory placode (OP) generates a broad array of chemosensory neurons in the nasal region, including olfactory sensory neurons, vomeronasal sensory neurons, neurons of the septal organ, and Grueneberg ganglion. During invagination, the OP also generates migratory neuronal populations, including gonadotropin‐releasing hormone‐1 (GnRH‐1 ...
Enrico Amato Jr., Mia V. Call, Noah M. LeFever, Mya Aviles‐Carlos, Nikki M. Dolphin, Paolo E. Forni   +5 more
wiley   +1 more source

Additional file 1 of Whole genome mutagenicity evaluation using Hawk-Seq™ demonstrates high inter-laboratory reproducibility and concordance with the transgenic rodent gene mutation assay

Supplementary Material 1.
Matsumura, Shoji, Hosoi, Sayaka, Hirose, Takako, Otsubo, Yuki, Saito, Kazutoshi, Miyazawa, Masaaki, Kawade, Akihiro, Hakura, Atsushi, Kakiuchi, Dai, Asakura, Shoji, Koyama, Naoki, Okada, Yuki, Chikura, Satsuki, Kimoto, Takafumi, Masumura, Kenichi, Suzuki, Takayoshi, Sugiyama, Kei-ichi   +16 more
openaire   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Additional file 2 of Whole genome mutagenicity evaluation using Hawk-Seq™ demonstrates high inter-laboratory reproducibility and concordance with the transgenic rodent gene mutation assay

Supplementary Material 2.
Matsumura, Shoji, Hosoi, Sayaka, Hirose, Takako, Otsubo, Yuki, Saito, Kazutoshi, Miyazawa, Masaaki, Kawade, Akihiro, Hakura, Atsushi, Kakiuchi, Dai, Asakura, Shoji, Koyama, Naoki, Okada, Yuki, Chikura, Satsuki, Kimoto, Takafumi, Masumura, Kenichi, Suzuki, Takayoshi, Sugiyama, Kei-ichi   +16 more
openaire   +1 more source

Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice [PDF]

, 2006
Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Expression of PS1 mutations in cell culture systems and in primary neurons from transgenic mice increases their vulnerability to cell ...
Czech, Christian, Schindowski, Katharina, Eckert, Anne, Leutner, Silke, Luckhaus, Christian, Touchet, Nathalie, Müller, Walter E.   +6 more
core   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the Muta™Mouse transgenic rodent assay [PDF]

, 2016
Test batteries to screen chemicals for mutagenic hazard include several endpoints regarded as effective for detecting genotoxic carcinogens. Traditional in vivo methods primarily examine clastogenic endpoints in haematopoietic tissues.
Long, Alexandra S., Arlt, Volker M.; id_orcid, Lemieux, Christine L., White, Paul A.   +3 more
core   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Constitutive expression of a grapevine polygalacturonase-inhibiting protein affects gene expression and cell wall properties in uninfected tobacco [PDF]

, 2011
Background Polygalacturonase-inhibiting proteins (PGIPs) directly limit the effective ingress of fungal pathogens by inhibiting cell wall-degrading endopolygalacturonases (ePGs).
Dan Jacobson, Becker, John V. W., Katherine J Denby, Vivier Melané A, Eric Nguema-Ona, Becker John VW, Steyn Cobus, Alexandersson, Erik, Vivier, Melané A., Nguema-Ona Eric, Vivier, Melane, John VW Becker, Denby Katherine J, Cobus Steyn, Denby, Katherine J., Denby, Katherine, Becker, John, Steyn, Cobus, Melané A Vivier, Jacobson, Dan, Nguema-Ona, Eric, Alexandersson Erik, Jacobson Dan, Erik Alexandersson, Nguema-Ona, E., Sveriges lantbruksuniversitet., Alexandersson, E.,, Vivier, M.A., Becker, J.V.W., Jacobson, D., Swedish University of Agricultural Sciences., Steyn, C., Alexandersson, Erik,, Denby, K.J.   +33 more
core   +1 more source

The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario, Margarita Díaz‐Martínez, Mario Alberto Viazcan‐Carbajal, Victor David González‐Fernández   +3 more
wiley   +1 more source