Results 121 to 130 of about 38,473 (198)

Immunoglobulin a Deficiency in Coeliac Disease: A Scoping Review

United European Gastroenterology Journal, Volume 14, Issue 8, October 2026.
ABSTRACT Coeliac disease (CeD) and immunoglobulin A deficiency (IgAD) frequently co‐occur and share a genetic background within the HLA‐DQ2 region. Although this has been known for decades, the underlying mechanisms linking the two conditions remain unclear.
Kristine Bech, Cæcilie Crawley, Rok Seon Choung, Joseph A. Murray, Steffen Husby   +4 more
wiley   +1 more source

The role of Transglutaminase Type 2 in Breast Cancer

reservedTransglutaminase Type 2 (TG2), member of the Mammalian Transglutaminase family, is a multi-functional and widely distributed protein localized in the cytosol, in the nucleus, in mitochondria, on the plasma membrane, and in the extracellular ...
GENOVESE, CHIARA
core  

Insights into the modulation of age‐related macular degeneration: Molecular and systems‐level perspectives

Acta Ophthalmologica, Volume 104, Issue S293, Page S4-S35, October 2026.
ENGLISH SUMMARY In developed countries, age‐related macular degeneration (AMD) is the leading cause of visual impairment in the aging population. Understanding of its pathogenesis is limited and the number of patients is predicted to continue rising. AMD is classified into two main forms: dry and neovascular AMD (dAMD and nAMD, respectively).
Hanna Heloterä
wiley   +1 more source

Long‐Term Follow‐Up Incidence of Type 1 Diabetes and Associated Autoimmune Diseases in First‐Degree Relatives

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9668-9679, October 2026.
ABSTRACT Background First‐degree relatives (FDRs) of individuals with type 1 diabetes (T1D) carry a significantly elevated risk of developing autoimmune diseases, including celiac disease (CD) and autoimmune thyroid disease (AITD). The DiaUnion 1.0 study aimed to characterize one‐time autoantibodies, genetic risk profiles and long‐term progression to ...
Julie H. Christensen, Gitte Lindved Petersen, Simranjeet Kaur, Alexander Lind, Samia Hamdan, Maria Naredi Scherman, Jesper Johannesen, Daniel Agardh, Julie C. Antvorskov, Flemming Pociot   +9 more
wiley   +1 more source

Discovery of Post‐Translationally Modified Epitopes in Autoimmunity: Someone Has to Fish so Everyone Can Eat

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT Post‐translational modifications (PTMs) chemically diversify the ~20,000 genomically encoded proteins into millions of functional variants, and this diversity has profound consequences for T cell‐mediated immune responses. PTM‐reactive T cells have been identified across numerous autoimmune diseases and, in several cases, implicated directly ...
Sanya Arshad, Benjamin M. Cameron, Alok V. Joglekar   +2 more
wiley   +1 more source

The transglutaminase activation precedes the developmental cell death wave (DCD) of Nicotiana tabacum flower. Oral presentation.

, 2007
The activity of transglutaminase (TGase), an enzyme responsible for polyamine conjugation to proteins, was analysed in relationship to developmental cell death (DCD) during the flower life span stages of the Nicotiana tabacum corolla. As the DCD exhibits
DELLA MEA, MASSIMILIANO, DEL DUCA, STEFANO, SERAFINI FRACASSINI, DONATELLA, De Filippis F., GENOVESI, VALERIA   +4 more
core   +1 more source

Beta Cell Stress to Epitope Diversification: Post‐Translationally Modified Antigens in Type 1 Diabetes

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT Pancreatic beta cells are active participants in the loss of immune tolerance because their high secretory demand creates exceptional vulnerability to inflammatory exposure, endoplasmic reticulum (ER) stress, calcium dysregulation, and redox imbalance. These conditions can promote enzymatic and nonenzymatic changes in self‐proteins, generating
Megan L. Proffer, Saptarshi Roy, Jon D. Piganelli   +2 more
wiley   +1 more source

Transcriptomic Dynamics Associated With In Vitro Oocyte Competence in Pigs

Reproduction in Domestic Animals, Volume 61, Issue S3, October 2026.
ABSTRACT Porcine in vitro embryo production (pIVP) would have a major impact on both livestock production and biomedical research if its efficiency—currently limited by suboptimal oocyte competence—could be improved. This study aimed to characterize transcriptional dynamics across oocyte in vitro maturation (IVM) and fertilization (IVF).
D. Gascón‐Collado, C. G. Cabrera‐Gomez, P. Blanco‐Cueto, H. Rodriguez‐Martinez, C. A. Martinez‐Serrano   +4 more
wiley   +1 more source

Artificial Intelligence and Virtual Screening to Identify Small Molecules Inhibiting Transglutaminase 2 for Investigation and Treatment of Breast Cancer

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
Artificial Intelligence (AI)‐guided screening of nearly 10 million molecules hit the bull’s‐eye: G11, a new nonpeptidic inhibitor of transglutaminase 2. A stepwise path from in silico ranking to cell and biochemical assays identified G11 as the top hit. It induced apoptosis in transglutaminase 2 (TG2)‐rich breast cancer cells and inhibited purified TG2,
Carlo M. Bergamini, Niel M. Henriksen, Brianna Ryan, Taylor A. Prince, Anna Terrazzan, Pietro Ancona, Cristina Zuccato, Gianluca Aguiari, Valentina Rosta, Jeffrey W. Keillor, Alessandro Trentini, Nicoletta Bianchi   +11 more
wiley   +1 more source

Biotin Availability Modulates Transglutaminase Expression and Activity during Lipid Accumulation in 3T3-F442A Adipocytes. [PDF]

MicroPubl Biol
Velez-delValle C, Castro-Muñozledo F, Kuri-Harcuch W, Padilla-Benavides T.   +3 more
europepmc   +1 more source