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Biocatalysis by Transglutaminases: A Review of Biotechnological Applications
Micromachines, 2018 The biocatalytic activity of transglutaminases (TGs) leads to the synthesis of new covalent isopeptide bonds (crosslinks) between peptide-bound glutamine and lysine residues, but also the transamidation of primary amines to glutamine residues, which ...
Elisa Tonoli, Elisabetta A M Verderio
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Biotechnological Applications of Transglutaminases
Biomolecules, 2013 In nature, transglutaminases catalyze the formation of amide bonds between proteins to form insoluble protein aggregates. This specific function has long been exploited in the food and textile industries as a protein cross-linking agent to alter the ...
Joelle N Pelletier
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Transglutaminases: Nature’s biological glues [PDF]
Biochemical Journal, 2002 Transglutaminases (Tgases) are a widely distributed group of enzymes that catalyse the post-translational modification of proteins by the formation of isopeptide bonds. This occurs either through protein cross-linking via ∊-(γ-glutamyl)lysine bonds or through incorporation of primary amines at selected peptide-bound glutamine residues. The cross-linked
Martin Griffin +2 more
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Histone serotonylation promotes pancreatic cancer development via lipid metabolism remodeling [PDF]
Nature CommunicationsNeurotransmitter serotonin (5-hydroxytryptamine [5-HT]) has emerged to play parallel roles in both neurobiology and oncology. Apart from receptor-mediated signaling transduction pattern, serotonin can be covalently integrated into histone (the post ...
Sang Lin +13 more
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Identification of transglutaminase 2 mediated polyaminated proteins in a hepatocellular cancer cell line [PDF]
Computational and Structural Biotechnology JournalPolyamines are abundant metabolites that are involved in many cellular processes. Despite playing wide-ranging and essential roles in the cell, only a few examples of a specific polyamine function are known.
Don Benjamin +4 more
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Mass Spectrometric Identification of a Novel Factor XIIIa Cross-Linking Site in Fibrinogen
Proteomes, 2021 Transglutaminases are a class of enzymes that catalyze the formation of a protein:protein cross-link between a lysine and a glutamine residue. These cross-links play important roles in diverse biological processes.
Mariya E. Semkova, J. Justin Hsuan
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Molecules, 2021 Polyamines are highly attractive vectors for tumor targeting, particularly with regards to the development of radiolabeled probes for imaging by positron emission (PET) and single-photon emission computed tomography (SPECT).
Robert Wodtke +2 more
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Cells, 2023 Osteoclasts are multinucleated, bone-resorbing giant cells derived from monocyte–macrophage cell lines. Increased bone resorption results in loss of bone mass and osteoporosis.
Sahar Ebrahimi Samani, Mari T. Kaartinen
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Insects, 2022 Transglutaminases are pleiotropic enzymes that in mosquitoes participate in the formation of the mating plug and the wound-induced antimalarial response.
Abinaya Ramakrishnan, Julián F. Hillyer
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Use of transglutaminases in foods and potential utilization of plants as a transglutaminase source – Review [PDF]
Biotemas, 2012 Transglutaminases (TGases) are enzymes able to catalyze acyl-transfer reactions introducing covalent cross-links between proteins, peptides and primary amines.
Fernando Bittencourt Luciano +1 more
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