Results 41 to 50 of about 4,824 (245)

Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia

Journal of Neuroinflammation, 2020
Background Polyamine catabolism plays a key role in maintaining intracellular polyamine pools, yet its physiological significance is largely unexplored.
Kamyar Zahedi, Marybeth Brooks, Sharon Barone, Negah Rahmati, Tracy Murray Stewart, Matthew Dunworth, Christina Destefano-Shields, Nupur Dasgupta, Steve Davidson, Diana M. Lindquist, Christine E. Fuller, Roger D. Smith, John L. Cleveland, Robert A. Casero, Manoocher Soleimani   +14 more
doaj   +1 more source

Biodegradable and Edible Milli‐Fluidic Logic Circuits

Advanced Materials Technologies, EarlyView.
Fully biodegradable and edible fluidic circuits are developed using gelatin‐based valves that operate at low pressure. Logic gates, a one‐bit memory, and a ring oscillator are demonstrated, showing that biodegradable materials can perform computation and control.
Shuhang Zhang, Bokeon Kwak, Özgün Ekrem, Dario Floreano   +3 more
wiley   +1 more source

Characterisation of a novel cold‐adapted calcium‐activated transglutaminase: implications for medicine and food processing

FEBS Open Bio, 2020
Transglutaminases are a family of enzymes that catalyse the cross‐linking of proteins by forming covalent bonds between lysine and glutamine residues in various polypeptides.
Rebeca Garcia Alvarez, Pralav Karki, Ida Elise Langleite, Ragna‐Johanne Bakksjø, Lutz Andreas Eichacker, Clemens Furnes   +5 more
doaj   +1 more source

Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment [PDF]

Anais Brasileiros de Dermatologia, 2014
Researches on DH have shown that it is not just a bullous skin disease, but a cutaneous-intestinal disorder caused by hypersensitivity to gluten. Exposure to gluten is the starting point of an inflammatory cascade capable of forming autoantibodies that ...
Marcos Vinícius Clarindo, Adriana Tomazzoni Possebon, Emylle Marlene Soligo, Hirofumi Uyeda, Roseli Terezinha Ruaro, Julio Cesar Empinotti   +5 more
doaj   +1 more source

Extrusion‐Based Bioprinting of Living Bioinks for Tissue and Organ Engineering

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting is presented as the most versatile route for fabricating living, heterogeneous tissues. Its ability to combine diverse bioinks, support matrices, and advanced printhead geometries transforms familiar constraints into powerful biofabrication opportunities.
Eric Silberman, Ester Sapir Baruch, Roni Cohen, Assaf Shapira, Tal Dvir   +4 more
wiley   +1 more source

Summary of population frequencies of nsSNVs alleles of transglutaminases in the ExAC database covering 60,706 individuals.

, 2017
Summary of population frequencies of nsSNVs alleles of transglutaminases in the ExAC database covering 60,706 individuals.
Máté A. Demény (3804700), Mónika Fuxreiter (24759), László Fésüs (129831), János András Mótyán (3804706), Kiruphagaran Thangaraju (3804703), Róbert Király (2440492)   +5 more
core   +1 more source

Triagem sorológica de familiares de pacientes com doença celíaca: anticorpos anti-endomísio, antitransglutaminase ou ambos? Serological screening of relatives of celiac disease patients: antiendomysium antibodies, anti-tissue transglutaminase or both?

Arquivos de Gastroenterologia, 2007
RACIONAL: A doença celíaca representa, na atualidade, a doença intestinal mais comum em populações caucasóides e apresenta prevalência que varia de 8% a 18% nos familiares dos pacientes.
Shirley Ramos da Rosa Utiyama, Flávia Raphaela Nass, Lorete Maria da Silva Kotze, Renato Mitsunori Nisihara, Altair Rogério Ambrosio, Iara Taborda de Messias-Reason   +5 more
doaj   +1 more source

Clinical picture of dermatitis herpetiformis

Przegląd Dermatologiczny, 2020
Dermatitis herpetiformis is a rare, chronic, autoimmune blistering disease with hypersensitivity to gluten with the presence of intense pruritus. Symptoms of the disease are symmetrical, polymorphic skin lesions in a typical location.
Joanna Rybak-d’Obyrn, Waldemar J. Placek   +1 more
doaj   +1 more source

Sulfated glycosaminoglycans inhibit transglutaminase 2 by stabilizing its closed conformation

Scientific Reports, 2022
Transglutaminases (TGs) catalyze the covalent crosslinking of proteins via isopeptide bonds. The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial role in the ...
Claudia Damaris Müller, Gloria Ruiz-Gómez, Sophie Cazzonelli, Stephanie Möller, Robert Wodtke, Reik Löser, Joanna Freyse, Jan-Niklas Dürig, Jörg Rademann, Ute Hempel, M. Teresa Pisabarro, Sarah Vogel   +11 more
doaj   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source