Novel interactions of transglutaminase-2 with heparan sulphate proteoglycans: reflection on physiological implications [PDF]
, 2008 This mini-review brings together information from publications and recent conference proceedings that have shed light on the biological interaction between transglutaminase-2 and heparan sulphate proteoglycans. We subsequently draw hypothesis of possible
A Scarpellini +51 more
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Role of plastid transglutaminase in LHCII polyamination and thylakoid electron and proton flow. [PDF]
PLoS ONE, 2012 Transglutaminases function as biological glues in animal cells, plant cells and microbes. In energy producing organelles such as chloroplasts the presence of transglutaminases was recently confirmed.
Nikolaos E Ioannidis +4 more
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Biological functionalities of Transglutaminase 2 and the possibility of its compensation by other members of the transglutaminase family [PDF]
, 2014 Transglutaminase 2 (TG2) is the most widely distributed and most abundantly expressed member of the transglutaminase family of enzymes, a group of intracellular and extracellular proteins that catalyze the Ca2+-dependent post-translational modification ...
Coussons, Peter J., Odii, Benedict O.
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High-level expression of a recombinant active microbial transglutaminase in Escherichia coli [PDF]
, 2015 Background: Bacterial transglutaminases are increasingly required as industrial reagents for in vitro modification of proteins in different fields such as in food processing as well as for enzymatic site-specific covalent conjugation of therapeutic ...
Bossi, Michele +7 more
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Transglutaminases in Monocytes and Macrophages
Medical Sciences, 2018 Macrophages are key players in various inflammatory disorders and pathological conditions via phagocytosis and orchestrating immune responses. They are highly heterogeneous in terms of their phenotypes and functions by adaptation to different organs and ...
Huifang Sun, Mari T. Kaartinen
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The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation [PDF]
, 2015 Autophagy is a self-degradative physiological process by which the cell removes worn-out or damaged components. Constant at basal level it may become highly active in response to cellular stress. The type 2 transglutaminase (TG2), which accumulates under
Belkin +61 more
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Transglutaminases and neurodegeneration [PDF]
Journal of Neurochemistry, 2009 AbstractTransglutaminases (TGs) are Ca2+‐dependent enzymes that catalyze a variety of modifications of glutaminyl (Q) residues. In the brain, these modifications include the covalent attachment of a number of amine‐bearing compounds, including lysyl (K) residues and polyamines, which serve to either regulate enzyme activity or attach the TG substrates ...
Thomas M, Jeitner +4 more
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Secretory leukocyte protease inhibitor (SLPI) is, like its homologue trappin-2 (pre-elafin), a transglutaminase substrate. [PDF]
PLoS ONE, 2011 Human lungs contain secretory leukocyte protease inhibitor (SLPI), elafin and its biologically active precursor trappin-2 (pre-elafin). These important low-molecular weight inhibitors are involved in controlling the potentially deleterious proteolytic ...
Kévin Baranger +4 more
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Production of the main celiac disease autoantigen by transient expression in Nicotiana benthamiana [PDF]
, 2015 Celiac Disease (CD) is a gluten sensitive enteropathy that remains widely undiagnosed and implementation of massive screening tests is needed to reduce the long term complications associated to untreated CD.
Acevedo, Gonzalo Raúl +4 more
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Syndecan-4 knockout leads to reduced extracellular transglutaminase-2 and protects against tubulointerstitial fibrosis [PDF]
, 2013 Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. The interaction of TG2 with the heparan sulfate proteoglycan syndecan-4 (Sdc4) regulates the cell surface trafficking, localization, and ...
Burhan, I +6 more
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