Results 11 to 20 of about 7,007 (263)

Genetic variation in the epidermal transglutaminase genes is not associated with atopic dermatitis. [PDF]

PLoS ONE, 2012
BackgroundAtopic dermatitis (AD) is a common chronic inflammatory skin disorder where epidermal barrier dysfunction is a major factor in the pathogenesis.
Agne Liedén, Mårten C G Winge, Annika Sääf, Ingrid Kockum, Elisabeth Ekelund, Elke Rodriguez, Regina Fölster-Holst, Andre Franke, Thomas Illig, Maria Tengvall-Linder, Hansjörg Baurecht, Stephan Weidinger, Carl-Fredrik Wahlgren, Magnus Nordenskjöld, Maria Bradley   +14 more
doaj   +1 more source

Plant Transglutaminases: New Insights in Biochemistry, Genetics, and Physiology

Cells, 2022
Transglutaminases (TGases) are calcium-dependent enzymes that catalyse an acyl-transfer reaction between primary amino groups and protein-bound Gln residues. They are widely distributed in nature, being found in vertebrates, invertebrates, microorganisms,
Luigi Parrotta, Umesh Kumar Tanwar, Iris Aloisi, Ewa Sobieszczuk-Nowicka, Magdalena Arasimowicz-Jelonek, Stefano Del Duca   +5 more
doaj   +1 more source

Tgm1-like transglutaminases in tilapia (Oreochromis mossambicus). [PDF]

PLoS ONE, 2017
Among the adaptations of aquatic species during evolution of terrestrial tetrapods was the development of an epidermis preventing desiccation. In present day mammals, keratinocytes of the epidermis, using a membrane-bound transglutaminase (Tgm1 ...
Sandra I Rodriguez Cruz, Marjorie A Phillips, Dietmar Kültz, Robert H Rice   +3 more
doaj   +1 more source

Genomic variants reveal differential evolutionary constraints on human transglutaminases and point towards unrecognized significance of transglutaminase 2. [PDF]

PLoS ONE, 2017
Transglutaminases (TGMs) catalyze Ca2+-dependent transamidation of proteins with specified roles in blood clotting (F13a) and in cornification (TGM1, TGM3).
Kiruphagaran Thangaraju, Róbert Király, Máté A Demény, János András Mótyán, Mónika Fuxreiter, László Fésüs   +5 more
doaj   +1 more source

Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V

Frontiers in Genetics, 2021
Keratosis follicularis spinulosa decalvans (KFSD) is a rare cornification disorder with an X-linked recessive inheritance in most cases. Pathogenic variants causing X-linked KFSD have been described in MBTPS2, the gene for a membrane-bound zinc ...
Katja M. Eckl, Robert Gruber, Louise Brennan, Andrew Marriott, Roswitha Plank, Roswitha Plank, Verena Moosbrugger-Martinz, Stefan Blunder, Anna Schossig, Janine Altmüller, Holger Thiele, Peter Nürnberg, Johannes Zschocke, Hans Christian Hennies, Hans Christian Hennies, Matthias Schmuth   +15 more
doaj   +1 more source

Expression of functional recombinant human tissue transglutaminase (TG2) using the bac-to-bac baculovirus expression system [PDF]

, 2016
Purpose: Tissue transglutaminase (TG2) is a unique multifunctional enzyme. The enzyme possesses enzymatic activities such as transamidation/crosslinking and non-enzymatic functions such as cell migration and signal transduction.
Azari, S., Kalhor, H.R., Yazdani, Y.
core   +2 more sources

Regulation of Pollen Tube Growth by Transglutaminase

Plants, 2013
In pollen tubes, cytoskeleton proteins are involved in many aspects of pollen germination and growth, from the transport of sperm cells to the asymmetrical distribution of organelles to the deposition of cell wall material.
Giampiero Cai, Donatella Serafini-Fracassini, Stefano Del Duca   +2 more
doaj   +1 more source

Transglutaminase 2 Expression and Its Prognostic Significance in Clear Cell Renal Cell Carcinoma [PDF]

Journal of Pathology and Translational Medicine, 2015
Background: A few recent studies have demonstrated a possible role of transglutaminase 2 (TG2) in tumorigenesis or progression of renal cell carcinoma (RCC).
Min Jee Park, Hae Woon Baek, Ye-Young Rhee, Cheol Lee, Jeong Whan Park, Hwal Woong Kim, Kyung Chul Moon   +6 more
doaj   +1 more source

Interplay between transglutaminases and heparan sulphate in progressive renal scarring [PDF]

, 2016
Transglutaminase-2 (TG2) is a new anti-fibrotic target for chronic kidney disease, for its role in altering the extracellular homeostatic balance leading to excessive build-up of matrix in kidney.
A Clayton, A Monsonego, A Scarpellini, A Scarpellini, AE Tee, AM Belkin, AM Waterhouse, B Ahvazi, B Hinz, BM Fraij, C Faye, C Klock, CA Harrison, CY Chou, D Aeschlimann, D Telci, D Telci, DJ Carey, E Candi, E Candi, E Verderio, E Verderio, EA Verderio, EA Verderio, F Echtermeyer, G David, H Lortat-Jacob, H Tatsukawa, HF Al-Jallad, I Nunes, J Taipale, JM Atkinson, JP Annes, JS Duffield, JW Celie, K Small, K Teesalu, KC Olsen, L Huang, L Huang, L Lorand, LP van den Heuvel, M Abe, M Fisher, M Kato, M Papasotiriou, M Raghunath, M Rudnicki, M Schuksz, M Stieler, MA Antonyak, ML Herman, P Boor, P Grenard, P Grenard, Q Chen, Q Fan, RL Eckert, S Kojima, S Yung, T Johnson, TS Johnson, TS Johnson, TS Johnson, TS Johnson, V Masola, VM Phatak, X Jin, Z Wang   +68 more
core   +4 more sources

MICROBIAL TRANSGLUTAMINASE: SOURCE, PRODUCTION AND ITS ROLE TO IMPROVE SURIMI PROPERTIES

Squalen, 2014
Transglutaminases (EC 2.3.2.13) have attracted a wide interest from both scientific and appliedpoints of view due to their capacity to cross-link protein substrates.
Dewi Zeswita Zilda
doaj   +1 more source