Results 71 to 80 of about 1,706,590 (302)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Polarisation response of delay dependent absorption modulation in strong field dressed helium atoms probed near threshold

New Journal of Physics, 2016
We present the first measurement of the vectorial response of strongly dressed helium atoms probed by an attosecond pulse train (APT) polarised either parallel or perpendicular to the dressing field polarisation.
E R Simpson, A Sanchez-Gonzalez, D R Austin, Z Diveki, S E E Hutchinson, T Siegel, M Ruberti, V Averbukh, L Miseikis, C S Strüber, L Chipperfield, J P Marangos   +11 more
doaj   +1 more source

Dynamics of Strongly Coupled Hybrid States by Transient Absorption Spectroscopy

, 2018
Dynamics of Strongly Coupled Hybrid States by Transient Absorption ...
Sun H. -B., De Angelis F., Razzari L., Wang H., Proietti Zaccaria R., Sun, Hong-Bo, Razzari, Luca, Jin X., Cerea A., Huang F., Cojoc, Dan, Jin, Xin, Wang H. -Y., Wang, Hai-Yu, Catone D., Toma, Andrea, Catone, Daniele, Huang, Fangcheng, Cerea, Andrea, Cojoc D., Wang, Hai, De Angelis, Francesco, Zaccaria, Remo Proietti, Toma A., Wang Hai, Daniele Catone, Razzari Luca, Remo Proietti Zaccaria, Toma Andrea, Cojoc Dan, Sun Hong Bo, De Angelis Francesco, Jin Xin, Francesco De Angelis, Andrea Toma, Xin Jin, Luca Razzari, Hai‐Yu Wang, Cerea Andrea, Hong‐Bo Sun, Catone Daniele, Huang Fangcheng, Dan Cojoc, Wang Hai Yu, Fangcheng Huang, Proietti Zaccaria Remo, Andrea Cerea, Hai Wang   +47 more
core   +1 more source

Probing Competing Relaxation Pathways in Malonaldehyde with Transient X-Ray Absorption Spectroscopy [PDF]

, 2020
Excited-state intramolecular hydrogen transfer (ESIHT) is a fundamental reaction relevant to chemistry and biology. Malonaldehyde is the simplest example of ESIHT, yet only little is known experimentally about its excited-state dynamics.
Andreas, Dreuw, Patrick, Norman, Todd J., Martínez, Nanna Holmgaard, List, Adrian, L. Dempwolff   +4 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

transient absorption spectroscopy of porphyrins 1-3

, 2019
transient absorption spectroscopy of porphyrins 1-3 in the presence and in the absence of cheno, in solution and absorbed on NiO ...
Elisabetta Benazzi (6862616)
core   +1 more source

Ultrafast Excited State Dynamics of a Verdazyl Diradical System

Photochem
While the photophysics of closed-shell organic molecules is well established, much less is known about open-shell systems containing interacting radical pairs.
Caitlyn Clark, Filip Pawłowski, David J. R. Brook, Christopher Grieco   +3 more
doaj   +1 more source

Ultrafast transient sub-bandgap absorption of monolayer MoS2

Light: Science & Applications, 2021
Photonics: Lighting the way to new photonic and optoelectronic applications Light–matter interactions in two-dimensional (2D) materials are of interest for applications such as lasers and solar cells, but these interactions drastically decrease below the
Susobhan Das, Yadong Wang, Yunyun Dai, Shisheng Li, Zhipei Sun   +4 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source