Results 81 to 90 of about 11,052 (171)

Considerations about Study on Mechanisms of Thermal Efficacies of Moxibustion from Activities of Transient Receptor Potential Family

针刺研究, 2012
Of the mammalian transient receptor potential(TRP) superfamily members,transient receptor potential vanilloid 1(TRPV 1),TRPV 2,TRPV 3,TRPV 4,melastatin transient receptor potential(TRPM) 4,TRPM 5,and TRP ankyrin 1(TRPA 1),are mostly permeable to both ...
LU Sheng-feng1, 2, YIN Hai-yan2, TANG Yong2, ZHANG Cheng-shun2, YU Mei-ling3, LUO Ling2   +6 more
doaj   +2 more sources

Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction

Journal of Inflammation, 2018
Background Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger.
Songjiang Yin, Li Zhang, Liang Ding, Zhengquan Huang, Bo Xu, XiaoChen Li, Peimin Wang, Jun Mao   +7 more
doaj   +1 more source

Advances in Cytosolic dsRNA Sensing of Viral Infections

Immunology &Cell Biology, EarlyView.
Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley   +1 more source

Effects of Clenching Intensity and Duration on Pressure Pain Threshold and Masseter‐Muscle Stiffness Under Standardised EMG‐Based Contraction Exposure

Journal of Oral Rehabilitation, EarlyView.
Under equivalent prescribed EMG‐based contraction exposure, pressure pain threshold was modestly but significantly lower immediately after low‐intensity, long‐duration clenching than after high‐intensity, short‐duration clenching, whereas the latter induced a transient reduction in masseter‐muscle stiffness.
Keisuke Miyazono, Hiroyuki Ishiyama, Akira Nishiyama, Kenji Fueki   +3 more
wiley   +1 more source

The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges

Frontiers in Pharmacology, 2019
The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily.
Zhen Wang, Zhen Wang, Zhen Wang, Di Ye, Di Ye, Di Ye, Jing Ye, Jing Ye, Jing Ye, Menglong Wang, Menglong Wang, Menglong Wang, Jianfang Liu, Jianfang Liu, Jianfang Liu, Huimin Jiang, Huimin Jiang, Huimin Jiang, Yao Xu, Yao Xu, Yao Xu, Jishou Zhang, Jiangbin Chen, Jun Wan, Jun Wan, Jun Wan   +25 more
doaj   +1 more source

Differential ubiquitin modifications of ESCRT‐I subunits VPS37‐1 and VPS28‐2 positively regulate plant immunity

New Phytologist, EarlyView.
The RING type ubiquitin ligase (E3), XBAT35.2, positively regulates FLS2‐mediated plant immunity against bacterial pathogens by modifying the ESCRT‐I subunits VPS28‐2 and VPS37‐1 with distinct ubiquitin chain types. Summary Sensing of pathogen‐associated molecular patterns (PAMPs) by pattern recognition receptors at the cell surface initiates the first
Chaofeng Wang, Yi Zhang, Bangjun Zhou, Pooja Verma, Lirong Zeng   +4 more
wiley   +1 more source

TRPA1 and TRPM8 in Allergic Rhinitis and Chronic Rhinosinusitis: Emerging Role in Neuroimmune Inflammation

Biomedicines
Nasal hyperreactivity (NHR) is a core symptom of allergic rhinitis (AR) and chronic rhinosinusitis (CRS), frequently induced by cold stimuli. Accumulating evidence indicates that NHR is largely mediated by neuroimmune mechanisms rather than classical ...
Tianhui Kang, Zijun Qiu, Surita Aodeng, Yuzhuo Liu, Zhenzhen Zhu, Wei Lv   +5 more
doaj   +1 more source

Formaldehyde Induces Mesenteric Artery Relaxation via a Sensitive Transient Receptor Potential Ankyrin-1 (TRPA1) and Endothelium-Dependent Mechanism: Potential Role in Postprandial Hyperemia

Frontiers in Physiology, 2019
Formaldehyde (FA), the smallest aldehyde, is generated endogenously, and is widespread in the environment in foods, beverages and as a gas phase product of incomplete combustion.
L. Jin, L. Jin, G. Jagatheesan, G. Jagatheesan, G. Jagatheesan, G. Jagatheesan, L. Guo, L. Guo, L. Guo, L. Guo, M. Nystoriak, M. Nystoriak, M. Nystoriak, M. Nystoriak, M. Malovichko, M. Malovichko, M. Malovichko, P. Lorkiewicz, P. Lorkiewicz, P. Lorkiewicz, P. Lorkiewicz, A. Bhatnagar, A. Bhatnagar, A. Bhatnagar, A. Bhatnagar, A. Bhatnagar, S. Srivastava, S. Srivastava, S. Srivastava, S. Srivastava, D. J. Conklin, D. J. Conklin, D. J. Conklin, D. J. Conklin, D. J. Conklin   +34 more
doaj   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Human and Mouse TRPA1 Are Heat and Cold Sensors Differentially Tuned by Voltage

Cells, 2019
Transient receptor potential ankyrin 1 channel (TRPA1) serves as a key sensor for reactive electrophilic compounds across all species. Its sensitivity to temperature, however, differs among species, a variability that has been attributed to an ...
Viktor Sinica, Lucie Zimova, Kristyna Barvikova, Lucie Macikova, Ivan Barvik, Viktorie Vlachova   +5 more
doaj   +1 more source