Results 71 to 80 of about 1,668,806 (304)

Linear response theory and transient fluctuation theorems for diffusion processes: a backward point of view

, 2009
On the basis of perturbed Kolmogorov backward equations and path integral representation, we unify the derivations of the linear response theory and transient fluctuation theorems for continuous diffusion processes from a backward point of view.
Bochkov G N, Cameron R H, Chernyak V, Chetrite R, Fei Liu, Gardiner C W, Harris R J, Huan Tong, Kac M, Karatzas I, Kubo R, Kurchan J, Kurchan J, Liu F, Maes C, Risken H, Rui Ma, Smoluchowski M V, Speck T, Speck T, Speck T, Stroock D W, Zhong-can Ou-Yang, Zinn-Justin J   +23 more
core   +1 more source

Non-linear autopilot design using the philosophy of variable transient response [PDF]

, 2009
The novel non-linear controller design methodology of Variable Transient Response (VTR) is presented in this research. The performance of VTR is compared to that of successful non-linear controller designs (such as Robust Inverse Dynamics Estimation and ...
Brindley, Joseph, Counsell, John M., Macdonald, Malcolm   +2 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

High Frequency Response of Volatile Memristors

Advanced Electronic Materials
In this theoretical study, the high‐frequency response of the electrothermal NbO2‐Mott threshold switch is focused, a real‐world electronic device, which has been proved to be relevant in several applications and is classified as a volatile memristor ...
Ioannis Messaris, Alon Ascoli, Ahmet S. Demirkol, Vasileios Ntinas, Dimitrios Prousalis, Ronald Tetzlaff   +5 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

DIAGNOSIS OF GROUPS OF ELECTRO-RADIO COMPONENTS ACCORDING TO THE TRANSIENT RESPONSES FOR THE DETECTION OF DEFECTS ON THE FUNCTIONAL CELLS

Вестник Дагестанского государственного технического университета: Технические науки, 2017
Objectives. A method for diagnosing electronic components with minimally complicated control and measuring instrumentation and the ability to obtain information from internal control points of operating units is developed. Methods.
T. A. Ismailov, I. G. Mironenko, Kh. M. Gajiyev, T. A. Chelushkina   +3 more
doaj   +1 more source