Results 81 to 90 of about 1,677,221 (305)

Dynamic analysis using finite element method for a nonlinear spring-supported disk: Technique to reduce second-order distortion due to diaphragm shape

Mechanical Engineering Journal, 2017
This research aims to reduce the second-order distortion due to diaphragm vibration. The quadratic term of the restoring force of nonlinear springs varies in the pulling and compression directions.
Mitsuharu WATANABE, Takao YAMAGUCHI, Manabu SASAJIMA, Tatsushi SASANUMA, Yoshio KOIKE   +4 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Transient Behavior Analysis of Offshore Wind Turbines During Lightning Strike to Multi-Blade

IEEE Access, 2018
A set of analytic formulas are presented to evaluate the circuit parameters of blade, tower, three-phase cable, and monopile foundation. On the basis of the circuit parameters, the circuit model is built and a transient analysis is carried out for the ...
Shiqi Tao, Xiaoqing Zhang, Yaowu Wang, Junfeng Yang   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Absence of Significant Light-Induced Changes in cAMP Levels in Sporangiophores of Phycomyces blakesleeanus [PDF]

, 1983
We were unable to find transient changes in the amount of cAMP or cGMP that had been proposed to mediate the light-growth response in sporangiophores of Phycomyces ...
Brandt, Michaela, Leutwiler, Leslie S.
core   +1 more source

Time-dependent screening of a positive charge distribution in metals: Excitons on an ultra-short time scale

, 2000
Experiments determining the lifetime of excited electrons in crystalline copper reveal states which cannot be interpreted as Bloch states [S. Ogawa {\it et al.}, Phys. Rev. B {\bf 55}, 10869 (1997)].
A. G. Eguiluz, D. Pines, F. Aryasetiawan, G. D. Mahan, G. S. Canright, H. Petek, I. Campillo, I. Campillo, I. Campillo, J. Cao, J. P. Perdew, K. Burke, M. Bockstedte, M. Rohlfing, M. S. Hybertsen, N. W. Ashcroft, R. Keyling, R. M. Dreizler, S. Albrecht, S. Ogawa, T. Hertel, W. Ekardt, W. Kohn, W. Ku, W.-D. Schöne, Walter Ekardt, Wolf-Dieter Schöne   +26 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Bending and vibration analysis of multi-folding laminate composite plate using finite element method

Vietnam Journal of Mechanics, 2012
This paper deals with the bending and vibration analysis of multi-folding laminate composite plate using finite element method based on the first order shear deformation theory (FSDT).
Tran Ich Thinh, Bui Van Binh, Tran Minh Tu   +2 more
doaj   +1 more source

Blade loss transient dynamics analysis, volume 2. Task 2: TETRA 2 user's manual [PDF]

This is the user's manual for the TETRA 2 Computer Code, a program developed in the NASA-Lewis Blade Loss Program. TETRA 2 calculates a turbine engine's dynamic structural response from applied stimuli. The calculation options are: (1) transient response;
Black, Gerald, Gallardo, Vincente C.
core   +1 more source