Results 91 to 100 of about 92,805 (264)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Power System Transient Stability Assessment Method Based on Improved XGBoost and Its Interpretable Analysis

Taiyuan Ligong Daxue xuebao
Purposes With the large-scale grid-connection of new energy and power electronic devices, the security and stability characteristics of new power systems are facing serious challenges, and data-driven methods provide feasible ideas for the establishment ...
WANG Jinhao, LI Rui, HAN Xiaoqing, QU Ying, CHANG Zezhou, BO Liming, NIU Zhewen   +6 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Transient Synchronous Stability Evaluation of Heterogeneous Power Grids With Grid‐Following and Grid‐Forming Converters by Manifold Theory

IET Renewable Power Generation
The energy function method developed from Lyapunov theory is a typical direct method to evaluate the transient synchronous stability of traditional power grids.
Saizhao Yang, Rui Ma, Yitong Li, Jinyu Wen   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Power System Transient Stability Assessment Based on Intelligent Enhanced Transient Energy Function Method

Energies
The development of power systems puts forward higher requirements for transient stability evaluations of power systems. The accuracy and timeliness of transient stability assessment are of great significance to the safe and stable operation of power ...
Tianxiao Mo, Jun Liu, Jiacheng Liu, Guangyao Wang, Yuting Li, Kaiwei Lin   +5 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A domain adaptation‐based convolutional neural network incorporating data augmentation for power system dynamic security assessment

The Journal of Engineering
Recently, deep learning (DL) based dynamic security assessment (DSA) methods have been very successful. However, although a DSA model can be trained well for a specific topology, it often does not perform well for other topologies.
Sasan Azad, Mohammad Taghi Ameli
doaj   +1 more source

Enhancing trustworthiness in deep learning-based transient stability assessment: A multi-head attention model with dual-level interpretability

International Journal of Electrical Power & Energy Systems
Applying deep learning (DL) methods to transient stability assessment (TSA) facilitates the rapid establishment of a direct connection between operational features and transient states.
Zhewen Niu, Yuxiang Wu, Songyan Lan, Chaohui Wu, Xiaoqing Han, Jie Chen   +5 more
doaj   +1 more source