Results 91 to 100 of about 355,526 (290)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Predictive Online Transient Stability Assessment for Enhancing Efficiency

IEEE Open Access Journal of Power and Energy
Online transient stability assessment (TSA) is essential for the reliable operation of power systems. The increasing deployment of phasor measurement units (PMUs) across power systems provides a wealth of fast, accurate, and detailed transient data ...
Rui Ma, Sara Eftekharnejad, Chen Zhong
doaj   +1 more source

Stability analysis of electric power systems for ‘more electric’ aircraft [PDF]

, 2008
This paper presents a comprehensive assessment of small-signal stability for a “more-electric” aircraft power system consisting of a synchronous variable-frequency generator which supplies several power electronic controlled loads via an 18-pulse ...
Griffo, Antonio, Howe, D., Wang, J.B.
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Intelligent Enhanced Method for Modern Power System Transient Voltage Stability Assessment Based on Improved Conditional Generative Adversarial Network

Energies
The increasing complexity and variability of operating conditions, along with the occurrence of low-probability cascading failures, imposes more stringent requirements on data-driven intelligent methods for power system stability analysis.
Fan Li, Zhe Zhang, Hanqing Liang, Guodong Guo, Yuan Si, Yawei Xue   +5 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Transient Stability Assessment of Power Systems Built upon a Deep Spatio-Temporal Feature Extraction Network

Energies
The rapid and accurate identification of power system transient stability status is a fundamental prerequisite for ensuring the secure and reliable operation of large-scale power grids.
Yu Nan, Meng Tong, Zhenzhen Kong, Huichao Zhao, Yadong Zhao   +4 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

State-space average modelling of 18-pulse diode rectifier [PDF]

The paper presents an averaged-value model of the direct symmetric topology of 18-pulse autotransformer AC-DC rectifiers. The model captures the key features of the dynamic characteristics of the rectifiers, while being time invariant and ...
Griffo, Antonio, Howe, D., Wang, J.B.
core