Results 91 to 100 of about 93,389 (292)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Fast methods for direct assessment of power system transient stability

, 1988
The authors present a new and simple method for transient stability assessment of multi-machine power systems. The criterion for assessment is given in terms of the rate of change of kinetic energy of individual machines subsequent to fault clearance ...
F.J. Al Azzawi, Narayana, C. L., Al Azzawi, F. J., Al Baldawi, F. F., C.L. Narayana, F.F. Al Baldawi   +5 more
core   +1 more source

Artificial Intelligence Techniques for Power System Transient Stability Assessment

, 2022
The high penetration of renewable energy sources, coupled with decommissioning of conventional power plants, leads to the reduction of power system inertia. This has negative repercussions on the transient stability of power systems.
Antonijo Kunac, Marin Despalatovic, Petar Sarajcev, Goran Petrovic   +3 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Probabilistic assessment of transient stability in reduced inertia systems [PDF]

, 2016
A probabilistic approach to assess the transient stability of power systems with increased penetration of wind and Photo-Voltaic generation is presented in this paper.
Jovica V. Milanovic, Milanovic, Jovica V., Panagiotis N. Papadopoulos, Adrees, Atia, Atia Adrees, Papadopoulos, Panagiotis; id_orcid   +5 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Transient stability assessment

, 2003
Työn tavoitteena oli kartoittaa vaihtoehtoisia menetelmiä perinteiselle aikatasossa tapahtuvalle kulmastabiilisuuden mallinnukselle käyttövarmuustarkastelussa.
Uski, Sanna
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Transient Voltage Stability Assessment Method Based on CWT-ResNet

Energies
Accurate and rapid transient voltage stability assessment is crucial for the safe and stable operation of new energy bases in desert and grassland regions.
Chong Shao, Yongsheng Jin, Bolin Zhang, Xin He, Chen Zhou, Haiying Dong   +5 more
doaj   +1 more source