Results 71 to 80 of about 92,805 (264)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Intelligent Enhanced Method for Modern Power System Transient Voltage Stability Assessment Based on Improved Conditional Generative Adversarial Network

Energies
The increasing complexity and variability of operating conditions, along with the occurrence of low-probability cascading failures, imposes more stringent requirements on data-driven intelligent methods for power system stability analysis.
Fan Li, Zhe Zhang, Hanqing Liang, Guodong Guo, Yuan Si, Yawei Xue   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Probabilistic transient stability assessment for on-line applications

International Journal of Electrical Power & Energy Systems, 2012
Abstract The increasing need to improve security monitoring of networks by system operators is the main motivation of the work described in this paper. The paper provides an algorithm for the on-line probabilistic transient stability assessment of existing or forecasted operating conditions.
Mehdi Abapour, Mahmoud-Reza Haghifam
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Transient Stability Assessment of Power Systems Built upon a Deep Spatio-Temporal Feature Extraction Network

Energies
The rapid and accurate identification of power system transient stability status is a fundamental prerequisite for ensuring the secure and reliable operation of large-scale power grids.
Yu Nan, Meng Tong, Zhenzhen Kong, Huichao Zhao, Yadong Zhao   +4 more
doaj   +1 more source

Transient stability assessment using projection formulations

IET Generation, Transmission & Distribution, 2009
Definitions of angle radius and coordinates axis are presented to propose a new transient stability method that is simple and reliable for transient stability assessment. The concept of angle radius is further developed to introduce the novel concept of projection energy function (PEF), which in turn allow to the assessment of critical clearing time ...
D.Z. Fang, J.G. Yang, W. Sun, Z.Y. Xue, S.Q. Yuan   +4 more
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transient Voltage Stability Assessment Method Based on CWT-ResNet

Energies
Accurate and rapid transient voltage stability assessment is crucial for the safe and stable operation of new energy bases in desert and grassland regions.
Chong Shao, Yongsheng Jin, Bolin Zhang, Xin He, Chen Zhou, Haiying Dong   +5 more
doaj   +1 more source