Results 101 to 110 of about 199,554 (295)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Voltage Stability Mechanism of Grid-Connected Permanent Magnet Synchronous Generator Under Large Grid-Side Disturbances

Energies
As a mainstream new energy generation technology, elucidating the grid-connected voltage stability mechanisms of permanent magnet synchronous generator (PMSG) is critical for ensuring stable integration of high-penetration renewable energy.
Xun Mao, Wangchao Dong, Kai Lyv, Wei Tang, Zhen Wang, Li Guo, Yong Zhan, Yang Pu   +7 more
doaj   +1 more source

Transient Voltage Stability Analysis of Offshore Wind Power Systems

Journal of Energy Research and Reviews
With the development of science and technology, the cost of offshore wind power development and transmission has gradually decreased, making offshore wind power technology a research hotspot. The installed capacity has been increasing year by year.
Haoyu Wang, Zhengjie Wu, Zhangruixi Wang
openaire   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Dynamic Reactive Power Allocation Method of Power Grid with High-Permeability PV Considering Transient Voltage Stability

Energies
In order to solve the risk of transient voltage instability caused by the increasing proportion of new energy represented by photovoltaic (PV) and dynamic load in the power grid, a dynamic reactive power compensation device configuration method with high-
Yangyang Li, Dongfeng Yang, Chuang Liu, Dongbo Guo, Yichen Gu, Jiahe Li   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Transient Damping of Virtual Synchronous Generator for Enhancing Synchronization Stability During Voltage Dips

CES Transactions on Electrical Machines and Systems
Virtual synchronous generators (VSGs) are widely introduced to the renewable power generation, the variable-speed pumped storage units, and so on, as a promising grid-forming solution.
Shitao Sun, Yu Lei, Guowen Hao, Yi Lu, Jindong Liu, Zhaoxin Song, Jie Zhang   +6 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Transient stability improvement of a transmission system through the application of an artificial neural network-based high-voltage direct current system

Energy Exploration & Exploitation
The increasing disturbances in power system networks present significant challenges to electrical power engineers, often leading to a loss of synchronism in grid-tied generators.
Chibuike Peter Ohanu, Uche C Ogbuefi, Emenike Ejiogu   +2 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source