Results 91 to 100 of about 76,246 (270)
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
The Astronomical JournalThe eight-planet Kepler-90 system exhibits the greatest multiplicity of planets found to date. All eight planets are transiting and were discovered in photometry from the NASA Kepler primary mission. The two outermost planets, g ( P _g = 211 days) and h
David E. Shaw +30 more
doaj +1 more source
The Hunt for Exomoons with Kepler (HEK): I. Description of a New Observational Project
, 2012 Two decades ago, empirical evidence concerning the existence and frequency of planets around stars, other than our own, was absent. Since this time, the detection of extrasolar planets from Jupiter-sized to most recently Earth-sized worlds has blossomed ...
A. Schmitt +49 more
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
The Astronomical JournalWe present new results for the hot Jupiters HAT-P-16b, TOI-1516b, and TOI-2046b, based on photometric observations collected using both space- and ground-based facilities.
E. Sonbas +7 more
doaj +1 more source
Degeneracy in the characterization of non-transiting planets from transit timing variations
, 2012 The transit timing variation (TTV) method allows the detection of non-transiting planets through their gravitational perturbations. Since TTVs are strongly enhanced in systems close to mean-motion resonances (MMR), even a low mass planet can produce an ...
Agol +18 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Detailed Architecture of the L 98-59 System and Confirmation of a Fifth Planet in the Habitable Zone
The Astronomical JournalThe L 98-59 system, identified by TESS in 2019, features three transiting exoplanets in compact orbits of 2.253, 3.691, and 7.451 days around an M3V star, with an outer 12.83 day nontransiting planet confirmed in 2021 using ESPRESSO.
Charles Cadieux +14 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
The Astrophysical Journal LettersWe report the discovery and characterization of a small planet, TOI-1408 c, on a 2.2 day orbit located interior to a previously known hot Jupiter, TOI-1408 b ( P = 4.42 days, M = 1.86 ± 0.02 M _Jup , R = 2.4 ± 0.5 R _Jup ) that exhibits grazing transits.
Judith Korth +62 more
doaj +1 more source