Results 91 to 100 of about 75,518 (268)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

TOI-1408: Discovery and Photodynamical Modeling of a Small Inner Companion to a Hot Jupiter Revealed by Transit Timing Variations

The Astrophysical Journal Letters
We report the discovery and characterization of a small planet, TOI-1408 c, on a 2.2 day orbit located interior to a previously known hot Jupiter, TOI-1408 b ( P = 4.42 days, M = 1.86 ± 0.02 M _Jup , R = 2.4 ± 0.5 R _Jup ) that exhibits grazing transits.
Judith Korth, Priyanka Chaturvedi, Hannu Parviainen, Ilaria Carleo, Michael Endl, Eike W. Guenther, Grzegorz Nowak, Carina M. Persson, Phillip J. MacQueen, Alexander J. Mustill, Juan Cabrera, William D. Cochran, Jorge Lillo-Box, David Hobbs, Felipe Murgas, Michael Greklek-McKeon, Hanna Kellermann, Guillaume Hébrard, Akihiko Fukui, Enric Pallé, Jon M. Jenkins, Joseph D. Twicken, Karen A. Collins, Samuel N. Quinn, Ján Šubjak, Paul G. Beck, Davide Gandolfi, Savita Mathur, Hans J. Deeg, David W. Latham, Simon Albrecht, David Barrado, Isabelle Boisse, Hervé Bouy, Xavier Delfosse, Olivier Demangeon, Rafael A. García, Artie P. Hatzes, Neda Heidari, Kai Ikuta, Petr Kabáth, Heather A. Knutson, John Livingston, Eder Martioli, María Morales-Calderón, Giuseppe Morello, Norio Narita, Jaume Orell-Miquel, Hanna L. M. Osborne, Dinil B. Palakkatharappil, Viktoria Pinter, Seth Redfield, Howard M. Relles, Richard P. Schwarz, Sara Seager, Avi Shporer, Marek Skarka, Gregor Srdoc, Monika Stangret, Luis Thomas, Vincent Van Eylen, Noriharu Watanabe, Joshua N. Winn   +62 more
doaj   +1 more source

PlanetPack software tool for exoplanets detection: coming new features

, 2014
We briefly overview the new features of PlanetPack2, the forthcoming update of PlanetPack, which is a software tool for exoplanets detection and characterization from Doppler radial velocity data. Among other things, this major update brings parallelized
Baluev, Roman V.
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

TOI-2015 b: A Warm Neptune with Transit Timing Variations Orbiting an Active Mid-type M Dwarf

The Astronomical Journal
We report the discovery of a close-in ( P _orb = 3.349 days) warm Neptune with clear transit timing variations (TTVs) orbiting the nearby ( d = 47.3 pc) active M4 star, TOI-2015.
Sinclaire E. Jones, Guđmundur Stefánsson, Kento Masuda, Jessica E. Libby-Roberts, Cristilyn N. Gardner, Rae Holcomb, Corey Beard, Paul Robertson, Caleb I. Cañas, Suvrath Mahadevan, Shubham Kanodia, Andrea S. J. Lin, Henry A. Kobulnicky, Brock A. Parker, Chad F. Bender, William D. Cochran, Scott A. Diddams, Rachel B. Fernandes, Arvind F. Gupta, Samuel Halverson, Suzanne L. Hawley, Fred R. Hearty, Leslie Hebb, Adam Kowalski, Jack Lubin, Andrew Monson, Joe P. Ninan, Lawrence Ramsey, Arpita Roy, Christian Schwab, Ryan C. Terrien, John Wisniewski   +31 more
doaj   +1 more source

Detection of transit timing variations in excess of one hour in the Kepler multi-planet candidate system KOI 806 with the GTC

, 2011
We report the detection of transit timing variations (TTVs) well in excess of one hour in the Kepler multi-planet candidate system KOI 806. This system exhibits transits consistent with three separate planets -- a Super-Earth, a Jupiter, and a Saturn ...
A. Cabrera-Lavers, Agol, B. Tingley, Bakos, Borucki, Claret, Cochran, Deeg, Doyle, E. Palle, F. Murgas, Ford, Ford, H. J. Deeg, H. Parviainen, Holman, Holman, I. Ribas, J. A. Belmonte, Kipping, Kipping, Lissauer, M. R. Zapatero Osorio, Nesvorný, O’Donovan, O’Donovan, P. M. Rodriguez, Storn, Tingley, Torres, Torres, Veras   +31 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Kepler-1624b Has No Significant Transit Timing Variations

The Astronomical Journal
It is relatively rare for gas giant planets to have resonant or near-resonant companions, but these systems are particularly useful for constraining planet formation and migration models. In this study, we examine Kepler-1624b, a sub-Saturn orbiting an M
Haedam Im, Morgan Saidel, Heather A. Knutson, Michael Greklek-McKeon, Shreyas Vissapragada, Karen A. Collins, Akihiko Fukui, Norio Narita, Kimberly Paragas, Richard P. Schwarz, Avi Shporer, Gregor Srdoc   +11 more
doaj   +1 more source

Degeneracy in the characterization of non-transiting planets from transit timing variations

, 2012
The transit timing variation (TTV) method allows the detection of non-transiting planets through their gravitational perturbations. Since TTVs are strongly enhanced in systems close to mean-motion resonances (MMR), even a low mass planet can produce an ...
Agol, Ballard, Ellis, Ford, G. Boué, Haghighipour, Holman, Holman, Kaula, Laskar, Laskar, Lissauer, M. Montalto, M. Oshagh, Meschiari, N. C. Santos, Nesvorný, Veras, Wisdom   +18 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source